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P2RX7: Expression R...
P2RX7: Expression Responds to Sleep Deprivation and Associates with Rapid Cycling in Bipolar Disorder Type 1
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- Backlund, L. (författare)
- Karolinska Institutet
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- Lavebratt, C. (författare)
- Karolinska Institutet
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- Frisen, L. (författare)
- Karolinska Institutet
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- Nikamo, P. (författare)
- Karolinska Institutet
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Sudic, D. H. (författare)
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- Träskman Bendz, Lil (författare)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Landén, Mikael, 1966 (författare)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Edman, G. (författare)
- Karolinska Institutet
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Vawter, M. P. (författare)
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- Osby, U. (författare)
- Karolinska Institutet
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- Schalling, M. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2012-08-28
- 2012
- Engelska.
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 27
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Abstract
Ämnesord
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- Context: Rapid cycling is a severe form of bipolar disorder with an increased rate of episodes that is particularly treatment-responsive to chronotherapy and stable sleep-wake cycles. We hypothesized that the P2RX7 gene would be affected by sleep deprivation and be implicated in rapid cycling. Objectives: To assess whether P2RX7 expression is affected by total sleep deprivation and if variation in P2RX7 is associated with rapid cycling in bipolar patients. Design: Gene expression analysis in peripheral blood mononuclear cells (PBMCs) from healthy volunteers and case-case and case-control SNP/haplotype association analyses in patients. Participants: Healthy volunteers at the sleep research center, University of California, Irvine Medical Center (UCIMC), USA (n = 8) and Swedish outpatients recruited from specialized psychiatric clinics for bipolar disorder, diagnosed with bipolar disorder type 1 (n = 569; rapid cycling: n = 121) and anonymous blood donor controls (n = 1,044). Results: P2RX7 RNA levels were significantly increased during sleep deprivation in PBMCs from healthy volunteers (p = 2.3*10(-9)). The P2RX7 rs2230912_A allele was more common (OR = 2.2, p = 0.002) and the ACGTTT haplotype in P2RX7 (rs1718119 to rs1621388) containing the protective rs2230912_G allele (OR = 0.45-0.49, p = 0.003-0.005) was less common, among rapid cycling cases compared to non-rapid cycling bipolar patients and blood donor controls. Conclusions: Sleep deprivation increased P2RX7 expression in healthy persons and the putatively low-activity P2RX7 rs2230912 allele A variant was associated with rapid cycling in bipolar disorder. This supports earlier findings of P2RX7 associations to affective disorder and is in agreement with that particularly rapid cycling patients have a more vulnerable diurnal system.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- single-nucleotide polymorphisms
- neurotrophic factor bdnf
- linkage
- disequilibrium
- synthase kinase-3
- p2x(7) receptors
- circadian clock
- mood disorders
- protein-kinase
- phase-shifts
- gene
- netics
- v150b
- p1063
- netics
- v153b
- p847
- netics
- v150b
- p295
- netics
- v141b
- p374
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Backlund, L.
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Lavebratt, C.
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Frisen, L.
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Nikamo, P.
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Sudic, D. H.
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Träskman Bendz, ...
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Landén, Mikael, ...
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Edman, G.
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Vawter, M. P.
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Osby, U.
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Schalling, M.
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