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Joint analysis of i...
Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.
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Huth, Cornelia (author)
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Illig, Thomas (author)
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Herder, Christian (author)
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show more...
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Gieger, Christian (author)
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Grallert, Harald (author)
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Vollmert, Caren (author)
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Rathmann, Wolfgang (author)
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Hamid, Yasmin H (author)
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Pedersen, Oluf (author)
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Hansen, Torben (author)
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Thorand, Barbara (author)
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Meisinger, Christa (author)
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Doring, Angela (author)
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Klopp, Norman (author)
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Gohlke, Henning (author)
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Lieb, Wolfgang (author)
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Hengstenberg, Christian (author)
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Lyssenko, Valeriya (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Ireland, Helen (author)
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Stephens, Jeffrey W (author)
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- Wernstedt Asterholm, Ingrid, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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- Jansson, John-Olov, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Boeing, Heiner (author)
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Mohlig, Matthias (author)
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Stringham, Heather M (author)
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Boehnke, Michael (author)
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Tuomilehto, Jaakko (author)
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Fernandez-Real, Jose-Manuel (author)
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Lopez-Bermejo, Abel (author)
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Gallart, Luis (author)
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Vendrell, Joan (author)
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Humphries, Steve E (author)
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Kronenberg, Florian (author)
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Wichmann, H-Erich (author)
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Heid, Iris M (author)
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(creator_code:org_t)
- 2009-07-08
- 2009
- English.
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In: Annals of medicine. - : Informa UK Limited. - 1365-2060 .- 0785-3890. ; 41:2, s. 128-38
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Abstract
Subject headings
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- BACKGROUND: Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. AIMS: This joint analysis aimed to clarify whether IL6 -174G>C was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). METHODS: Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P>0.1), they were combined by using the inverse-variance fixed-effect model. RESULTS: The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174G>C and BMI or interleukin-6 levels, except in some subgroups. CONCLUSIONS: Our data suggest that C-allele carriers of the IL6 -174G>C polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Blood Glucose
- analysis
- Body Mass Index
- Diabetes Mellitus
- Type 2
- blood
- epidemiology
- genetics
- physiopathology
- Epidemiology
- Molecular
- Humans
- Interleukin-6
- blood
- genetics
- Phenotype
- Polymorphism
- Single Nucleotide
- meta-analysis
- molecular epidemiology
- single nucleotide polymorphism
- intermediate phenotype
- interleukin-6
- inflammation mediators
- genes
- diabetes mellitus type 2
- Blood glucose
- body mass index
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Huth, Cornelia
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Illig, Thomas
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Herder, Christia ...
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Gieger, Christia ...
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Grallert, Harald
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Vollmert, Caren
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show more...
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Rathmann, Wolfga ...
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Hamid, Yasmin H
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Pedersen, Oluf
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Hansen, Torben
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Thorand, Barbara
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Meisinger, Chris ...
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Doring, Angela
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Klopp, Norman
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Gohlke, Henning
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Lieb, Wolfgang
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Hengstenberg, Ch ...
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Lyssenko, Valeri ...
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Groop, Leif
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Ireland, Helen
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Stephens, Jeffre ...
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Wernstedt Asterh ...
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Jansson, John-Ol ...
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Boeing, Heiner
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Mohlig, Matthias
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Stringham, Heath ...
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Boehnke, Michael
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Tuomilehto, Jaak ...
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Fernandez-Real, ...
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Lopez-Bermejo, A ...
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Gallart, Luis
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Vendrell, Joan
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Humphries, Steve ...
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Kronenberg, Flor ...
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Wichmann, H-Eric ...
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Heid, Iris M
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Annals of medici ...
- By the university
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University of Gothenburg
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Lund University