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Plasma Metabolome a...
Plasma Metabolome and Circulating Vitamins Stratified Onset Age of an Initial Islet Autoantibody and Progression to Type 1 Diabetes : the TEDDY Study
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- Li, Qian (författare)
- Shriners Hospitals for Children,University of South Florida,Farr Institute of Health Informatics Research,University of South Florida; Department of Sociology
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- Liu, Xiang (författare)
- University of South Florida; Department of Sociology
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- Yang, Jimin (författare)
- University of South Florida; Department of Sociology
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- Erlund, Iris (författare)
- Finnish National Institute for Health and Welfare
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- Lernmark, Åke (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Hagopian, William (författare)
- Pacific Northwest Research Institute
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- Rewers, Marian (författare)
- University of Colorado-Denver
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- She, Jin-Xiong (författare)
- Medical College of Georgia
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- Toppari, Jorma (författare)
- Turku University Hospital
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- Ziegler, Anette-G (författare)
- Jalisco Institute of Diabetes and Obesity Research SC
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- Akolkar, Beena (författare)
- National Institutes Of Health Clinical Center
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- Krischer, Jeffrey P (författare)
- University of South Florida; Department of Sociology
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(creator_code:org_t)
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- 2020-10-26
- 2021
- Engelska 11 s.
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Ingår i: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 70:1, s. 282-292
- Relaterad länk:
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http://dx.doi.org/10...
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https://diabetesjour...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Children's plasma metabolome, especially lipidome reflects gene regulation and dietary exposures, heralding the development of islet autoantibodies (IA) and type 1 diabetes (T1D). The TEDDY study enrolled 8676 newborns by screening HLA-DR-DQ genotypes at six clinical centers in four countries; profiled metabolome and measured concentrations of ascorbic acid, 25-hydroxyvitamin D (25(OH)D), erythrocyte membrane fatty acids following birth until IA seroconversion under nested case-control design. We grouped children having an initial autoantibody only against insulin (IAA-first) or glutamic acid decarboxylase (GADA-first) by unsupervised clustering of temporal lipidome, identifying a subgroup of children having early onset of each initial autoantibody, i.e., IAA-first by 12 months and GADA-first by 21 months, consistent with population-wide early seroconversion age. Differential analysis showed that infants having reduced plasma ascorbic acid and cholesterol experienced IAA-first earlier, while early onset of GADA-first was preceded by reduced sphingomyelins at infancy. Plasma 25(OH)D prior to either autoantibody was lower in T1D progressors compared to non-progressors, with simultaneous lower diglycerides, lysophosphatidylcholines, triglycerides, alanine before GADA-first. Plasma ascorbic acid and 25(OH)D at infancy were lower in HLA-DR3/DR4 children among IA cases but not in matched controls, implying gene expression dysregulation of circulating vitamins as latent signals for IA or T1D progression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Li, Qian
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Liu, Xiang
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Yang, Jimin
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Erlund, Iris
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Lernmark, Åke
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Hagopian, Willia ...
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visa fler...
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Rewers, Marian
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She, Jin-Xiong
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Toppari, Jorma
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Ziegler, Anette- ...
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Akolkar, Beena
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Krischer, Jeffre ...
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