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Common variants at 30 loci contribute to polygenic dyslipidemia
- Kathiresan, Sekar (author)
- Willer, Cristen J. (author)
- Peloso, Gina M. (author)
- show more...
- Demissie, Serkalem (author)
- Musunuru, Kiran (author)
- Schadt, Eric E. (author)
- Kaplan, Lee (author)
- Bennett, Derrick (author)
- Li, Yun (author)
- Tanaka, Toshiko (author)
- Voight, Benjamin F. (author)
- Bonnycastle, Lori L. (author)
- Jackson, Anne U. (author)
- Crawford, Gabriel (author)
- Surti, Aarti (author)
- Guiducci, Candace (author)
- Burtt, Noel P. (author)
- Parish, Sarah (author)
- Clarke, Robert (author)
- Zelenika, Diana (author)
- Kubalanza, Kari A. (author)
- Morken, Mario A. (author)
- Scott, Laura J. (author)
- Stringham, Heather M. (author)
- Galan, Pilar (author)
- Swift, Amy J. (author)
- Kuusisto, Johanna (author)
- Bergman, Richard N. (author)
- Sundvall, Jouko (author)
- Laakso, Markku (author)
- Ferrucci, Luigi (author)
- Scheet, Paul (author)
- Sanna, Serena (author)
- Uda, Manuela (author)
- Yang, Qiong (author)
- Lunetta, Kathryn L. (author)
- Dupuis, Josee (author)
- de Bakker, Paul I. W. (author)
- O'Donnell, Christopher J. (author)
- Chambers, John C. (author)
- Kooner, Jaspal S. (author)
- Hercberg, Serge (author)
- Meneton, Pierre (author)
- Lakatta, Edward G. (author)
- Scuteri, Angelo (author)
- Schlessinger, David (author)
- Tuomilehto, Jaakko (author)
- Collins, Francis S. (author)
- Altshuler, David (author)
- Collins, Rory (author)
- Lathrop, G. Mark (author)
- Salomaa, Veikko (author)
- Peltonen, Leena (author)
- Ordovas, Jose M. (author)
- Boehnke, Michael (author)
- Abecasis, Goncalo R. (author)
- Mohlke, Karen L. (author)
- Cupples, L. Adrienne (author)
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- (creator_code:org_t)
- 2008-12-07
- 2009
- English.
- In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:1, s. 56-65
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840 individuals and replication in up to 20,623 individuals. We identified 30 distinct loci associated with lipoprotein concentrations (each with P < 5 x 10(-8)), including 11 loci that reached genome-wide significance for the first time. The 11 newly defined loci include common variants associated with LDL cholesterol near ABCG8, MAFB, HNF1A and TIMD4; with HDL cholesterol near ANGPTL4, FADS1-FADS2-FADS3, HNF4A, LCAT, PLTP and TTC39B; and with triglycerides near AMAC1L2, FADS1-FADS2-FADS3 and PLTP. The proportion of individuals exceeding clinical cut points for high LDL cholesterol, low HDL cholesterol and high triglycerides varied according to an allelic dosage score (P < 10(-15) for each trend). These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- Kaplan, Lee
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