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Assessment of moder...
Assessment of moderate coffee consumption and risk of epithelial ovarian cancer : a Mendelian randomization study
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- Ong, Jue-Sheng (författare)
- QIMR Berghofer Medical Research Institute,QIMR Berghofer Med Res Inst, Genet & Computat Biol Dept, 300 Herston Rd, Herston, Qld 4006, Australia.;Univ Queensland, Sch Med, St Lucia, Qld, Australia.
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- Hwang, Liang-Dar (författare)
- QIMR Berghofer Medical Research Institute,QIMR Berghofer Med Res Inst, Genet & Computat Biol Dept, 300 Herston Rd, Herston, Qld 4006, Australia.;Univ Queensland, Sch Med, St Lucia, Qld, Australia.
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- Cuellar-Partida, Gabriel (författare)
- QIMR Berghofer Med Res Inst, Genet & Computat Biol Dept, 300 Herston Rd, Herston, Qld 4006, Australia.
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- Martin, Nicholas G (författare)
- QIMR Berghofer Med Res Inst, Genet & Computat Biol Dept, 300 Herston Rd, Herston, Qld 4006, Australia.
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- Chenevix-Trench, Georgia (författare)
- QIMR Berghofer Med Res Inst, Genet & Computat Biol Dept, 300 Herston Rd, Herston, Qld 4006, Australia.
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- Quinn, Michael C J (författare)
- QIMR Berghofer Med Res Inst, Genet & Computat Biol Dept, 300 Herston Rd, Herston, Qld 4006, Australia.
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- Cornelis, Marilyn C (författare)
- Northwestern Univ, Feinberg Sch Med, Prevent Med, Chicago, IL 60611 USA.
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- Gharahkhani, Puya (författare)
- QIMR Berghofer Med Res Inst, Genet & Computat Biol Dept, 300 Herston Rd, Herston, Qld 4006, Australia.
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- Webb, Penelope M (författare)
- QIMR Berghofer Med Res Inst, Populat Hlth Dept, Herston, Qld, Australia.
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- MacGregor, Stuart (författare)
- QIMR Berghofer Medical Research Institute,QIMR Berghofer Med Res Inst, Genet & Computat Biol Dept, 300 Herston Rd, Herston, Qld 4006, Australia.
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- Olsson, Håkan (creator_code:cre_t)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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QIMR Berghofer Medical Research Institute QIMR Berghofer Med Res Inst, Genet & Computat Biol Dept, 300 Herston Rd, Herston, Qld 4006, Australia;Univ Queensland, Sch Med, St Lucia, Qld, Australia. (creator_code:org_t)
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- 2017-11-25
- 2018
- Engelska.
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Ingår i: International Journal of Epidemiology. - : Oxford University Press (OUP). - 1464-3685 .- 0300-5771. ; 47:2, s. 450-459
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Abstract
Ämnesord
Stäng
- Background: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal.Methods: We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator.Results: For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80 mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases.Conclusions: We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Carcinoma, Ovarian Epithelial/epidemiology
- Coffee/adverse effects
- Female
- Humans
- Mendelian Randomization Analysis
- Odds Ratio
- Ovarian Neoplasms/epidemiology
- Polymorphism, Single Nucleotide
- Risk Factors
- Mendelian randomization
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Ong, Jue-Sheng
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Hwang, Liang-Dar
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Cuellar-Partida, ...
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Martin, Nicholas ...
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Chenevix-Trench, ...
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Quinn, Michael C ...
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Cornelis, Marily ...
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Gharahkhani, Puy ...
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Webb, Penelope M
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MacGregor, Stuar ...
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Olsson, Håkan
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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Lunds universitet
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