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1.	Garcia-Bennett, Alfonso, et al. (author) Mesoporous ASD : Fundamentals 2014 In: Amorphous Solid Dispersions. - New York : Springer. - 9781493915989 - 9781493915972 ; , s. 637-663 Book chapter (peer-reviewed)abstract Mesoporous silica materials are having an impact in traditional pharmaceutical applications and nanomedicine. As excipients, they are allowing the enhancement of poorly soluble drugs with significant improvements in solubility for a large variety of type II drug compounds. Synthetic and structural versatility allows to truly design both mesopore structure and mesopore size with great precision promising to allow for a library of standard materials that can deliver tailored pharmacokinetic release profiles. In this chapter, we highlight some of the important developments in the field of mesoporous materials focusing on early synthetic aspects as well as later functionalisation strategies. The characterisation methods that are employed commonly and may be used to facilitate production and quality assessment are also discussed. Finally, we update the reader with some brief examples of how these non-toxic and biocompatible vehicles are entering pharmaceutical applications.

Garcia-Bennett, Alfonso, et al. (author)
Mesoporous ASD : Fundamentals
2014
In: Amorphous Solid Dispersions. - New York : Springer. - 9781493915989 - 9781493915972 ; , s. 637-663
Book chapter (peer-reviewed)abstract
- Mesoporous silica materials are having an impact in traditional pharmaceutical applications and nanomedicine. As excipients, they are allowing the enhancement of poorly soluble drugs with significant improvements in solubility for a large variety of type II drug compounds. Synthetic and structural versatility allows to truly design both mesopore structure and mesopore size with great precision promising to allow for a library of standard materials that can deliver tailored pharmacokinetic release profiles. In this chapter, we highlight some of the important developments in the field of mesoporous materials focusing on early synthetic aspects as well as later functionalisation strategies. The characterisation methods that are employed commonly and may be used to facilitate production and quality assessment are also discussed. Finally, we update the reader with some brief examples of how these non-toxic and biocompatible vehicles are entering pharmaceutical applications.

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