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- Vlahos, Ross, et al.
(author)
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Neutralizing granulocyte/macrophage colony-stimulating factor inhibits cigarette smoke-induced lung inflammation.
- 2010
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In: American journal of respiratory and critical care medicine. - 1535-4970. ; 182:1, s. 34-40
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Journal article (peer-reviewed)abstract
- Cigarette smoke is the major cause of chronic obstructive pulmonary disease (COPD), and there is currently no satisfactory therapy to treat people with COPD. We have previously shown that granulocyte/macrophage colony-stimulating factor (GM-CSF) regulates lung innate immunity to LPS through Akt/Erk activation of nuclear factor-kappaB and activator protein (AP)-1.
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