| 1. |
- Ambrosio, Fabrisia, et al.
(författare)
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Biological basis of exercise-based treatments for musculoskeletal conditions
- 2011
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Ingår i: PM&R. - 1934-1482. ; 3:6 Suppl 1, s. S59-S63
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Tidskriftsartikel (refereegranskat)abstract
- Exercise-based therapies are the cornerstone of rehabilitation programs. While the benefits of exercise on systemic and tissue function are generally accepted, mechanisms underlying these benefits are sometimes poorly understood. An improved understanding of the effects of mechanical loading on molecular and cellular processes has the potential to lead to more disease-specific and efficacious exercise-based therapies. The purpose of this paper is to review the current literature examining the role of mechanical signaling on muscle and cartilage biology.
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| 2. |
- Kadi, Fawzi, 1970-
(författare)
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The influence of physical exercise on adult stem cells
- 2011
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Ingår i: Genetic and molecular aspects of sports performance. - Chichester, West Sussex, UK : Blackwell Publishing. - 978-1-4443-3445-6 ; s. 343-349
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Bokkapitel (övrigt vetenskapligt)
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| 3. |
- Mackey, A. L., et al.
(författare)
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Myogenic response of human skeletal muscle to 12 weeks of resistance training at light loading intensity
- 2011
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Ingår i: Scandinavian Journal of Medicine and Science in Sports. - 0905-7188. ; 21:6, s. 773-782
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Tidskriftsartikel (refereegranskat)abstract
- There is strong evidence for enhanced numbers of satellite cells with heavy resistance training. The satellite cell response to very light muscle loading is, however, unknown. We, therefore, designed a 12-week training protocol where volunteers trained one leg with a high load (H) and the other leg with a light load (L). Twelve young healthy men [mean age 25 ± 3 standard deviation (SD) years] volunteered for the study. Muscle biopsies were collected from the m. vastus lateralis of both legs before and after the training period and satellite cells were visualized by CD56 immunohistochemistry. A significant main effect of time was observed (P<0.001) for the number of CD56+ cells per fiber (L: from 0.11 ± 0.02 to 0.13 ± 0.03; H: from 0.12 ± 0.03 to 0.15 ± 0.05, mean ± SD). The finding that 12 weeks of training skeletal muscle even with very light loads can induce an increase in the number of satellite cells reveals a new aspect of myogenic precursor cell activation and suggests that satellite cells may play a role in skeletal muscle adaptation over a broad physiological range.
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| 4. |
- Ponsot, Elodie, 1973-, et al.
(författare)
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Telomere length of anterior crucial ligament after rupture : similar telomere length in injured and noninjured ACL portions
- 2011
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Ingår i: Journal of Orthopaedic Research. - 0736-0266. ; 29:1, s. 79-83
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Tidskriftsartikel (refereegranskat)abstract
- The regeneration of ligaments following injury is a slow process compared to the healing of many other tissues and the underlying mechanisms remain unknown. The purpose of the study was to evaluate the proliferative potential of ligaments by assessing telomere length within three distinct parts of human anterior cruciate ligament (ACL) obtained during ACL reconstruction: the macroscopically injured proximal part and macroscopically noninjured mid- and distal portions in eight subjects (age 28 +/- 8 years). The mean telomere length in ACL was within normal range of values usually reported for other tissues indicating that the endogenous machinery responsible for the proliferative potential of ligament is not implicated in its poor healing capacity. The three ACL parts showed similar mean TRF lengths (distal part: 11.5 +/- 0.8 kbp, mid-portion: 11.8 +/- 1.2 kbp, proximal part: 11.9 +/- 1.6 kbp) and there was no relationship between mean telomere length in ACL and the healing duration after rupture. This implies that despite the occurrence of ligament repair including a phase of intense cell proliferation the proliferative potential of ruptured ACL is not impaired. This knowledge is important for scientists and clinicians aiming to understand the mechanisms behind the low healing capacity of ligament. (C) 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29: 79-83, 2011
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