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Sökning: swepub > Övrigt vetenskapligt/konstnärligt > Göteborgs universitet > Forssell Aronsson Eva 1961

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  • Andersson, Charlotte, et al. (författare)
  • Diurnal variations in biodistribution of the radionuclide I-131 in mice
  • 2016
  • Ingår i: Swedish Cancer Research Meeting, Gothenburg, 2016, November 7-8.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Background: Radionuclides are routinely used to diagnose and treat many different types of cancer. I-131 is a well-established radioisotope used in e.g. treatment of thyroid cancer and neuroblastoma. Accurate knowledge of I-131 biodistribution is essential to correctly estimate the absorbed dose to normal organs and determine potential risks from I-131 exposure, which is especially important when treating children. Many biological functions in living organisms follow a circadian rhythm. Nevertheless, little is known about diurnal variations in radionuclide biodistribution. This study investigates if circadian rhythm affects I-131 biodistribution in mice and absorbed dose to organs and tissues. Materials & Methods: The radioactivity concentration in mice tissues was studied at different time-points after administration of I-131, and absorbed doses were calculated. The effect of circadian rhythm was studied by varying the time of administration. Results: Difference in activity concentration between the administration time-points was observed at many time-points after administration for most investigated tissues. For some organs differences were also observed in the absorbed dose. The highest activity concentration and absorbed dose were found in the thyroid regardless of time of administration. Conclusion: The results demonstrate that the biodistribution of I-131 in mice is influenced by the time of day of administration. These findings advocate that circadian rhythm should be considered in biodistribution studies and suggests that time-point of administration of radiopharmaceuticals containing I-131 for therapy can be further optimized. An optimized time-point could result in higher absorbed dose to the tumor and/or lower absorbed dose to normal tissues.
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  • Ahlman, Håkan, 1947, et al. (författare)
  • The relevance of somatostatin receptors in thyroid neoplasia.
  • 1997
  • Ingår i: The Yale journal of biology and medicine. - 0044-0086. ; 70:5-6, s. 523-33
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • 111In-octreotide scintigraphy in patients with persistent medullary thyroid carcinoma (MTC) visualized tumors in about half of the surgically explored sites. Tumor visualization correlated with rapid tumor growth and large tumor volume as judged from calcitonin levels. The 111In concentration ratio between tumor (T) and blood (B) in surgically excised lymph node metastases of MTC showed a large variation, with low values for microscopic and high values for macroscopic metastases in individual patients. Three cases of MTC, Hürthle cell adenoma and papillary thyroid cancer are reported with preoperative scintigraphy, T/B ratios and Northern analyses of the surgical biopsies. Visualization of tumors was possible in the absence of sstr2 (the high affinity receptor for octreotide) with the exception of microscopic tumor growth. T/B values in the patient with Hürthle cell adenoma were similar to those found in the contralateral thyroid lobe with goitre. The relatively high uptake of 111In in benign thyroid conditions probably limits the use of octreotide scintigraphy in the diagnosis of primary tumors. The technique has certain advantages over radioiodine scintigraphy after the surgical treatment of thyroid tumors: no need for withdrawal of thyroxin substitution; a possibility to diagnose metastases of tumors that do not concentrate radioiodine (MTC, Hürthle cell cancer); and complementary information about metastatic sites of non-medullary thyroid cancer (papillary and follicular tumors).
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Forssell-Aronsso... (165)Ta bort avgränsningen
Helou, Khalil, 1966 (78)
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Parris, Toshima Z, 1 ... (61)
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Shubbar, Emman, 1974 (19)
Montelius, Mikael, 1 ... (19)
Swanpalmer, John, 19 ... (17)
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Isaksson, Mats, 1961 (14)
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Ahlman, Håkan, 1947 (7)
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