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Sökning: swepub > Övrigt vetenskapligt/konstnärligt > Johansson B.

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  • Covacu, Ruxandra, et al. (författare)
  • Nitric oxide exposure diverts neural stem cell fate from neurogenesis towards astrogliogenesis
  • 2006
  • Ingår i: Stem Cells. - : Oxford University Press (OUP). - 1066-5099 .- 1549-4918. ; 178, s. 268-268
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Regeneration of cells in the central nervous system is a process that might be affected during neurological disease and trauma. Because nitric oxide (NO) and its derivatives are powerful mediators in the inflammatory cascade, we have investigated the effects of pathophysiological concentrations of NO on neurogenesis, gliogenesis, and the expression of proneural genes in primary adult neural stem cell cultures. After exposure to NO, neurogenesis was downregulated, and this corresponded to decreased expression of the proneural gene neurogenin-2 and beta-III-tubulin. The decreased ability to generate neurons was also found to be transmitted to the progeny of the cells. NO exposure was instead beneficial for astroglial differentiation, which was confirmed by increased activation of the Janus tyrosine kinase/signal transducer and activator of transcription transduction pathway. Our findings reveal a new role for NO during neuroinflammatory conditions, whereby its proastroglial fate-determining effect on neural stem cells might directly influence the neuroregenerative process.
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  • Paulraj, Alagar Raj, et al. (författare)
  • Electrochemical Performance and in Operando Charge Efficiency Measurements of Cu/Sn-Doped Nano Iron Electrodes
  • 2019
  • Ingår i: Batteries. - : MDPI. - 2313-0105. ; :1
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Fe-air or Ni-Fe cells can offer low-cost and large-scale sustainable energy storage. At present, they are limited by low coulombic efficiency, low active material use, and poor rate capability. To overcome these challenges, two types of nanostructured doped iron materials were investigated: (1) copper and tin doped iron (CuSn); and (2) tin doped iron (Sn). Single-wall carbon nanotube (SWCNT) was added to the electrode and LiOH to the electrolyte. In the 2 wt. % Cu + 2 wt. % Sn sample, the addition of SWCNT increased the discharge capacity from 430 to 475 mAh g−1, and charge efficiency increased from 83% to 93.5%. With the addition of both SWCNT and LiOH, the charge efficiency and discharge capacity improved to 91% and 603 mAh g−1, respectively. Meanwhile, the 4 wt. % Sn substituted sample performance is not on par with the 2 wt. % Cu + 2 wt. % Sn sample. The dopant elements (Cu and Sn) and additives (SWCNT and LiOH) have a major impact on the electrode performance. To understand the relation between hydrogen evolution and charge current density, we have used in operando charging measurements combined with mass spectrometry to quantify the evolved hydrogen. The electrodes that were subjected to prolonged overcharge upon hydrogen evolution failed rapidly. This insight could help in the development of better charging schemes for the iron electrodes.
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