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| 2. |
- Perman, Jeanna, 1981-, et al.
(författare)
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The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction.
- 2011
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Ingår i: The Journal of clinical investigation. - 1558-8238. ; 121:7, s. 2625-40
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Tidskriftsartikel (refereegranskat)abstract
- Impaired cardiac function is associated with myocardial triglyceride accumulation, but it is not clear how the lipids accumulate or whether this accumulation is detrimental. Here we show that hypoxia/ischemia-induced accumulation of lipids in HL-1 cardiomyocytes and mouse hearts is dependent on expression of the VLDL receptor (VLDLR). Hypoxia-induced VLDLR expression in HL-1 cells was dependent on HIF-1α through its interaction with a hypoxia-responsive element in the Vldlr promoter, and VLDLR promoted the endocytosis of lipoproteins. Furthermore, VLDLR expression was higher in ischemic compared with nonischemic left ventricles from human hearts and was correlated with the total lipid droplet area in the cardiomyocytes. Importantly, Vldlr-/- mice showed improved survival and decreased infarct area following an induced myocardial infarction. ER stress, which leads to apoptosis, is known to be involved in ischemic heart disease. We found that ischemia-induced ER stress and apoptosis in mouse hearts were reduced in Vldlr-/- mice and in mice treated with antibodies specific for VLDLR. These findings suggest that VLDLR-induced lipid accumulation in the ischemic heart worsens survival by increasing ER stress and apoptosis.
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| 3. |
- Björström Svanström, Cecilia M., et al.
(författare)
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Device performance of APFO-3/PCBM solar cells with controlled morphology
- 2009
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Ingår i: Advanced Materials. - Weinheim. - 0935-9648. ; 21:43, s. 4398-4403
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Tidskriftsartikel (refereegranskat)abstract
- Polymer/fullerene solar cells with three different device structures: A) diffuse bilayer, B) spontaneously formed multilayer, and C) vertically homogenous thin films, are fabricated. The photocurrent/voltage performance is compared and it is found that the self-stratified structure (B) yields the highest energy conversion efficiency.
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| 4. |
- Brostrom, A., et al.
(författare)
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Investing in Localized Relationships with Universities: What are the Benefits for RD Subsidiaries of Multinational Enterprises?
- 2009
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Ingår i: Industry and Innovation. - 1366-2716. ; 16:1, s. 59-78
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Tidskriftsartikel (refereegranskat)abstract
- In spite of a long-standing interest in the distribution of knowledge spillovers from university research, there is only limited theoretical understanding of if and when opportunities to interact with a research university constitute a significant force of attraction for globally mobile investment in RD. Based on an empirical investigation of the benefits of interaction with universities, this paper proposes an analytical framework and four ideal types of strategy for localised collaboration between RD subsidiaries and universities. This taxonomy, which largely transcends industry sectors, and the illustrative cases presented in this paper provide insights into the potential scope for localised university-industry interaction from the perspective of multinational enterprises. By connecting the empirical results to the question whether these benefits are significant enough to enhance a region's attractiveness as a location for RD, we are able to develop a better understanding of the alternative strategies for policymakers and university leaders interested in stimulating such linkages.
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| 5. |
- Grigoriev, Anton, et al.
(författare)
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Electron transport in stretched monoatomic gold wires
- 2006
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Ingår i: Physical Review Letters. - 0031-9007. ; 97:23, s. 236807
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Tidskriftsartikel (refereegranskat)abstract
- The conductance of monoatomic gold wires containing 3-7 gold atoms has been obtained from ab initio calculations. The transmission is found to vary significantly depending on the wire stretching and the number of incorporated atoms. Such oscillations are determined by the electronic structure of the one-dimensional (1D) part of the wire between the contacts. Our results indicate that the conductivity of 1D wires can be suppressed without breaking the contact.
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| 6. |
- Höjer, Mattias, et al.
(författare)
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Scenarios in selected tools for environmental systems analysis
- 2008
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Ingår i: Journal of Cleaner Production. - 0959-6526. ; 16:18, s. 1958-1970
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Tidskriftsartikel (refereegranskat)abstract
- A number of different tools for analysing environmental impacts of different systems have been developed. These include procedural tools such as strategic environmental assessment (SEA) and environmental management systems (EMS) as well as analytical ones such as life cycle assessment (LCA), life cycle costing (LCC), cost-benefit analysis (CBA) and the system of economic and environmental accounts (SEEA) including input-output analysis (IOA). Descriptions or scenarios of the future are typically relevant elements in these tools, since they are often used to describe impacts in the future. For futures studies a number of different approaches and techniques have been developed. In an earlier paper we have presented a typology of different types of scenarios that respond to different types of questions. These include predictive scenarios, explorative scenarios and normative scenarios. The aim of this paper is to explore connections between selected tools for environmental systems analysis and different scenario types. Although there is a clear need for futures studies in several tools for environmental systems analysis, it is interesting to note that the literature on methodologies for and case studies of combinations of futures studies and environmental systems analysis tools is rather limited. This suggests that there is a need for further research in this area including both methodoloy and practical case studies.
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| 7. |
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| 8. |
- Stillström, Carin, 1979-, et al.
(författare)
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The concept of mobile manufacturing
- 2007
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Ingår i: Journal of manufacturing systems. - Elsevier Ltd. - 0278-6125. ; 26:3-4, s. 188-193
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Tidskriftsartikel (refereegranskat)abstract
- It is increasingly important to locate manufacturing activities close to the most relevant competence or the most interesting market. The possibility to easily and quickly move manufacturing capacity is thus becoming more important. Hence, the demand for mobile manufacturing has increased and requires solutions for a quick, rational, and economical reconfiguration of the production system. Within the research project Factory-in-a-Box, the concept of mobile manufacturing has been investigated through the development and implementation of five operative demonstrators. This paper will analyze the concept of mobile manufacturing by presenting the results from the Factory-in-a-Box research project and its demonstrator development. The objective is to clarify when mobile manufacturing capacity can be a proper solution to use as well as to discuss future possible industrial manufacturing applications. The results show that there is a large range of applications for the concept of mobile manufacturing and that two dimensions – the geographical distance and the organizational distance – can be used to classify the mobility within manufacturing systems.
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| 9. |
- Svensson, Inger-Lise, et al.
(författare)
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Excess Heat from Kraft Pulp Mills: Trade-offs between Internal and External Use in the Case of Sweden - Part 1: Methodology
- 2008
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Ingår i: Energy Policy. - 0301-4215. ; 36:11, s. 4009-4298
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Tidskriftsartikel (refereegranskat)abstract
- Excess heat from a kraft pulp mill can be used either internally to increase the level of efficiency in the mill, or externally for example as district heating. This paper presents an approach to investigate the competition between external and internal use through modelling the pulp mill and an energy company (ECO) within the same system boundary. Three different sizes of ECOs with different district heating demands are studied. To investigate the competitiveness of using industrial excess heat as district heating compared with other heat production techniques, the option of investing in excess heat use is introduced, along with the possibility for the ECO to invest in biomass combined heat and power (CHP), waste CHP and natural gas combined cycle (NGCC). To evaluate the robustness of the model, alternative solutions are identified and will be used as a comparison to the optimal solutions. The model has been verified by comparing the results with previous studies concerning kraft pulp mills and with related studies regarding district heating and real ECOs. Finally, the approach presented in this part of the study will be used in the second part in order to investigate the trade-off between internal and external use of excess heat under different future energy market scenarios.
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| 10. |
- Viberg, Mats, 1961-, et al.
(författare)
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Maximum Likelihood Array Processing in Spatially Correlated Noise Fields Using Parametrized Signals
- 1997
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Ingår i: IEEE Transactions on Signal Processing. - 1053-587X. ; 45:4, s. 996-1004
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Tidskriftsartikel (refereegranskat)abstract
- This paper deals with the problem of estimating signal parameters using an array of sensors. This problem is of interest in a variety of applications, such as radar and sonar source localization. A vast number of estimation techniques have been proposed in the literature during the past two decades. Most of these can deliver consistent estimates only if the covariance matrix of the background noise is known. In many applications, the aforementioned assumption is unrealistic. Recently, a number of contributions have addressed the problem of signal parameter estimation in unknown noise environments based on various assumptions on the noise. Herein, a different approach is taken. We assume instead that the signals are partially known. The received signals are modeled as linear combinations of certain known basis functions. The exact maximum likelihood (ML) estimator for the problem at hand is derived, as well as computationally more attractive approximation. The Cramer-Rao lower bound (CRB) on the estimation error variance is also derived and found to coincide with the CRB, assuming an arbitrary deterministic model and known noise covariance.
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