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  • Gilbert, Jonas, 1968- (författare)
  • A Start for Implementing ORCID in the Swedish Research Information Infrastructure
  • 2013
  • Ingår i: ScieCom Info. - 1652-3202. ; 9:2
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • Texten presenterar i korthet det projekt kring författaridentifikatorer och publikationsdatabaser som Kungliga biblioteket finansierade under 2012 under projektledning av Stockholms universitetsbibliotek med deltagande av biblioteken vid Chalmers, Karolinska Institutet samt Malmö högskola.
  • Landgren, Sara, et al. (författare)
  • A novel ARC gene polymorphism is associated with reduced risk of Alzheimer's disease
  • 2012
  • Ingår i: Journal of Neural Transmission. - 0300-9564. ; 119:7, s. 833-842
  • Tidskriftsartikel (refereegranskat)abstract
    • Alzheimers disease (AD) is the most common neurodegenerative disease, and is clinically characterized by cognitive disturbances and the accumulation of the amyloid beta (A beta) peptides in plaques in the brain. Recent studies have shown the links between AD and the immediate-early gene Arc (activity-regulated cytoskeleton-associated protein), involved in synaptic plasticity and memory consolidation. For example, AD mouse models show a decreased expression of Arc mRNA in the brain. In additional, acute A beta application to brain slices leads to a widespread ARC protein diffusion, unlike the normal defined localization to synapses. In this study, we investigated genetic variation in human ARC and the risk of developing AD. To this end, we genotyped 713 subjects diagnosed with AD and 841 controls without dementia. ARC was sequenced in a group of healthy individuals, and seven previously known SNPs and three novel SNPs were identified. Two of the newly found SNPs were intronic and one, +2852(G/A), was located in the 3UTR. Three tag SNPs were selected, including the novel SNP +2852(G/A), to relate to risk of AD, Mini Mental State Examination (MMSE) scores and cerebrospinal fluid (CSF) biomarker levels of total tau (T-tau), hyperphosphorylated tau181 (P-tau(181)) and A beta(1-42). The AA genotype of the newly found 3-UTR SNP +2852(A/G), was associated with a decreased risk of AD (p (c) = 0.005; OR = 0.74; 95 % CI: 0.61-0.89). No associations of single SNPs or haplotypes with MMSE score or CSF biomarkers were found. Here we report a novel ARC SNP associated with a reduced risk of developing AD. To our knowledge, this is the first study associating a gene variant of ARC with any disease. The location of the SNP within the 3UTR indicates that dendritic targeting of ARC mRNA could be involved in the molecular mechanisms underlying this protective function. However, further investigation of the importance of this SNP for ARC function, ARC processing and the pathology of AD is needed.
  • Pecorari, Diane, 1964-, et al. (författare)
  • English for Academic Purposes at Swedish universities
  • 2011
  • Ingår i: Ibérica. - 1139-7241. ; :22, s. 55-78
  • Tidskriftsartikel (refereegranskat)abstract
    • In a parallel-language environment the use of textbooks in English in courses otherwise in the local language is naturalized and not widely discussed or questioned. The aim of this study was to elicit the attitudes and syllabus infrastructure that underlie the practice. A large-scale survey was carried out and answers were obtained from over 20% of teachers at Swedish universities. Results confirmed that a majority regarded English as important during and/or after university studies and showed that they considered the use of Englishlanguage textbooks as providing a useful opportunity for incidental language learning. In strong contrast to the situation in a content and language integrated learning environment, only a small minority of courses were reported to have any specified learning outcome related to English. Open answers showed awareness of the benefits and risks of parallel-language practices, but no interest in making aims explicit. In our view, there is no contradiction between incidental learning and explicit aims, and course aims which remain implicit make rational planning and constructive alignment more difficult. They also inhibit discussion of appropriate methodology.
  • Perman, Jeanna, 1981-, et al. (författare)
  • The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction.
  • 2011
  • Ingår i: The Journal of clinical investigation. - 1558-8238. ; 121:7, s. 2625-40
  • Tidskriftsartikel (refereegranskat)abstract
    • Impaired cardiac function is associated with myocardial triglyceride accumulation, but it is not clear how the lipids accumulate or whether this accumulation is detrimental. Here we show that hypoxia/ischemia-induced accumulation of lipids in HL-1 cardiomyocytes and mouse hearts is dependent on expression of the VLDL receptor (VLDLR). Hypoxia-induced VLDLR expression in HL-1 cells was dependent on HIF-1α through its interaction with a hypoxia-responsive element in the Vldlr promoter, and VLDLR promoted the endocytosis of lipoproteins. Furthermore, VLDLR expression was higher in ischemic compared with nonischemic left ventricles from human hearts and was correlated with the total lipid droplet area in the cardiomyocytes. Importantly, Vldlr-/- mice showed improved survival and decreased infarct area following an induced myocardial infarction. ER stress, which leads to apoptosis, is known to be involved in ischemic heart disease. We found that ischemia-induced ER stress and apoptosis in mouse hearts were reduced in Vldlr-/- mice and in mice treated with antibodies specific for VLDLR. These findings suggest that VLDLR-induced lipid accumulation in the ischemic heart worsens survival by increasing ER stress and apoptosis.
  • Björström Svanström, Cecilia M., et al. (författare)
  • Device performance of APFO-3/PCBM solar cells with controlled morphology
  • 2009
  • Ingår i: Advanced Materials. - Weinheim. - 0935-9648. ; 21:43, s. 4398-4403
  • Tidskriftsartikel (refereegranskat)abstract
    • Polymer/fullerene solar cells with three different device structures: A) diffuse bilayer, B) spontaneously formed multilayer, and C) vertically homogenous thin films, are fabricated. The photocurrent/voltage performance is compared and it is found that the self-stratified structure (B) yields the highest energy conversion efficiency.
  • Brostrom, A., et al. (författare)
  • Investing in Localized Relationships with Universities: What are the Benefits for RD Subsidiaries of Multinational Enterprises?
  • 2009
  • Ingår i: Industry and Innovation. - 1366-2716. ; 16:1, s. 59-78
  • Tidskriftsartikel (refereegranskat)abstract
    • In spite of a long-standing interest in the distribution of knowledge spillovers from university research, there is only limited theoretical understanding of if and when opportunities to interact with a research university constitute a significant force of attraction for globally mobile investment in RD. Based on an empirical investigation of the benefits of interaction with universities, this paper proposes an analytical framework and four ideal types of strategy for localised collaboration between RD subsidiaries and universities. This taxonomy, which largely transcends industry sectors, and the illustrative cases presented in this paper provide insights into the potential scope for localised university-industry interaction from the perspective of multinational enterprises. By connecting the empirical results to the question whether these benefits are significant enough to enhance a region's attractiveness as a location for RD, we are able to develop a better understanding of the alternative strategies for policymakers and university leaders interested in stimulating such linkages.
  • Grigoriev, Anton, et al. (författare)
  • Electron transport in stretched monoatomic gold wires
  • 2006
  • Ingår i: Physical Review Letters. - 0031-9007. ; 97:23, s. 236807
  • Tidskriftsartikel (refereegranskat)abstract
    • The conductance of monoatomic gold wires containing 3-7 gold atoms has been obtained from ab initio calculations. The transmission is found to vary significantly depending on the wire stretching and the number of incorporated atoms. Such oscillations are determined by the electronic structure of the one-dimensional (1D) part of the wire between the contacts. Our results indicate that the conductivity of 1D wires can be suppressed without breaking the contact.
  • Hulander, Mats, et al. (författare)
  • Gradients in surface nanotopography used to study platelet adhesion and activation
  • 2013
  • Ingår i: Colloids and Surfaces B-Biointerfaces. - 0927-7765. ; 110, s. 261-269
  • Tidskriftsartikel (refereegranskat)abstract
    • Gradients in surface nanotopography were prepared by adsorbing gold nanoparticles on smooth gold substrates using diffusion technique. Following a sintering procedure the particle binding chemistry was removed, and integration of the particles into the underlying gold substrate was achieved, leaving a nanostructured surface with uniform surface chemistry. After pre-adsorption of human fibrinogen, the effect of surface nanotopography on platelets was studied. The use of a gradient in nanotopography allowed for platelet adhesion and activation to be studied as a function of nanoparticle coverage on one single substrate. A peak in platelet adhesion was found at 23% nanoparticle surface coverage. The highest number of activated platelets was found on the smooth control part of the surface, and did not coincide with the number of adhered platelets. Activation correlated inversely with particle coverage, hence the lowest fraction of activated platelets was found at high particle coverage. Hydrophobization of the gradient surface lowered the total number of adhering cells, but not the ratio of activated cells. Little or no effect was seen on gradients with 36 nm particles, suggesting the existence of a lower limit for sensing of surface nano-roughness in platelets. These results demonstrate that parameters such as ratio between size and inter-particle distance can be more relevant for cell response than wettability on nanostructured surfaces. The minor effect of hydrophobicity, the generally reduced activation on nanostructured surfaces and the presence of a cut-off in activation of human platelets as a function of nanoparticle size could have implications for the design of future blood-contacting biomaterials.
  • Höjer, Mattias, et al. (författare)
  • Scenarios in selected tools for environmental systems analysis
  • 2008
  • Ingår i: Journal of Cleaner Production. - 0959-6526. ; 16:18, s. 1958-1970
  • Tidskriftsartikel (refereegranskat)abstract
    • A number of different tools for analysing environmental impacts of different systems have been developed. These include procedural tools such as strategic environmental assessment (SEA) and environmental management systems (EMS) as well as analytical ones such as life cycle assessment (LCA), life cycle costing (LCC), cost-benefit analysis (CBA) and the system of economic and environmental accounts (SEEA) including input-output analysis (IOA). Descriptions or scenarios of the future are typically relevant elements in these tools, since they are often used to describe impacts in the future. For futures studies a number of different approaches and techniques have been developed. In an earlier paper we have presented a typology of different types of scenarios that respond to different types of questions. These include predictive scenarios, explorative scenarios and normative scenarios. The aim of this paper is to explore connections between selected tools for environmental systems analysis and different scenario types. Although there is a clear need for futures studies in several tools for environmental systems analysis, it is interesting to note that the literature on methodologies for and case studies of combinations of futures studies and environmental systems analysis tools is rather limited. This suggests that there is a need for further research in this area including both methodoloy and practical case studies.
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