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  • Gilbert, Jonas, 1968- (författare)
  • A Start for Implementing ORCID in the Swedish Research Information Infrastructure
  • 2013
  • Ingår i: ScieCom Info. - 1652-3202. ; 9:2
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • Texten presenterar i korthet det projekt kring författaridentifikatorer och publikationsdatabaser som Kungliga biblioteket finansierade under 2012 under projektledning av Stockholms universitetsbibliotek med deltagande av biblioteken vid Chalmers, Karolinska Institutet samt Malmö högskola.
  • Axelsson, Ann-Sofie, 1967-, et al. (författare)
  • Att etablera ett kollaboratorium inom biblioteks- och informationsvetenskap: behov och utmaningar från ett praktikerperspektiv
  • 2007
  • Ingår i: Svensk Biblioteksforskning. - 0284-4354. ; 16:1
  • Tidskriftsartikel (refereegranskat)abstract
    • This article describes a study that investigated the need for and challenges connected to the establishment of a collaboratory - a sociotechnical forum where information and other resources can be made accessible and used by practitioners within library and information science. In order to identify needs and challenges interviews were carried out with a number of practitioners at a number of different institutions. The results reveal that there is a need for a collaboratory in order to facilitate the sharing of personal knowledge “on demand”. It is of great importance that the collaboratory is well integrated with practitioner’s daily activities.
  • Svedberg, U.R.A., et al. (författare)
  • Emission of hexanal and carbon monoxide from storage of wood pellets, a potential occupational and domestic health hazard
  • 2004
  • Ingår i: Annals of Occupational Hygiene. - 0003-4878. ; 48:4, s. 339-349
  • Tidskriftsartikel (refereegranskat)abstract
    •  Objectives: The objective of the present study was to investigate and describe the emissions of volatile compounds, particularly hexanal and carbon monoxide, from large- and small-scale storage of wood pellets.Methods: Air sampling was performed with Fourier transform infrared spectroscopy and adsorbent sampling in pellet warehouses, domestic storage rooms, lumber kiln dryers and experimental set-ups. Literature studies were included to describe the formation of hexanal and carbon monoxide and the toxicology of hexanal.Results: A geometric mean aldehyde level of 111 +/- 32 mg/m(3) was found in one warehouse, with a peak reading of 156 mg/m(3). A maximum aldehyde reading of 457 mg/m(3) was recorded at the surface of a pellet pile. Hexanal (70-80% w/w) and pentanal (10-15% w/w) dominated, but acetone (821 +/- 24 mg/m(3)), methanol (18 7 mg/m(3)) and carbon monoxide (56 +/- 4 mg/m(3)) were also found. The emissions in a domestic storage room varied with the ambient temperature and peaked after 2 months storage in the midst of the warm season. Aldehyde levels of 98 +/- 4 mg/m(3) and carbon monoxide levels of 123 +/- 10 mg/m(3) were recorded inside such storage rooms. Elevated levels of hexanal (0.084 mg/m(3)) were recorded inside domestic housing and 6 mg/m(3) in a room adjacent to a poorly sealed storage area. Experimental laboratory studies confirmed the findings of the field studies. A field study of the emissions from industrial lumber drying also showed the formation of aldehydes and carbon monoxide.Conclusions: High levels of hexanal and carbon monoxide were strongly associated with storage of wood pellets and may constitute an occupational and domestic health hazard. The results from lumber drying show that the emissions of hexanal and carbon monoxide are not limited to wood pellets but are caused by general degradation processes of wood, facilitated by drying at elevated temperature. Emission of carbon monoxide from wood materials at low temperatures (<100degreesC) has not previously been reported in the literature. We postulate that carbon monoxide is formed due to autoxidative degradation of fats and fatty acids. A toxicological literature survey showed that the available scientific information on hexanal is insufficient to determine the potential risks to health. However, the data presented in this paper seem sufficient to undertake preventive measures to reduce exposure to hexanal.
  • Undeland, Ingrid, 1968-, et al. (författare)
  • Lipid Oxidation in Fillets of Herring (Clupea harengus) during Ice Storage
  • 1999
  • Ingår i: Journal of Agricultural and Food Chemistry. - 0021-8561. ; 47:2, s. 524-532
  • Tidskriftsartikel (refereegranskat)abstract
    • Fillets of herring (Clupea harengus) were kept in ice for 0, 3, 6 and 9 days prior to storage at -18 °C for 0, 3, 6, 9 and 12 weeks. At each storage point, peroxide value (PV), absorbance at 268 nm (A268), fluorescent products (FP), ?-tocopherol, glutathione peroxidase (GSH-px) and ascorbic acid were measured. As shown by regression analyses, samples held for 6 days on ice formed oxidation products with the highest rate during frozen storage, followed by, for PV and FP, the 9-day samples. These data indicate that severe changes negatively affecting the oxidation process took place in the herring muscle between 3 and 6 days after catch. The rate of antioxidant loss at -18 °C decreased with increased pre-freezing holding, something which was most obvious for GSH-px and ascorbic acid. ?-Tocopherol showed the largest losses, and after 82 days at -18 °C, the 6-day sample had completely run out of this compound. Partial least square regression (PLS) analysis of all data showed that the ice storage had a larger effect than the frozen storage on changes in PV, A268, FP, ?-tocopherol and ascorbic acid. For GSH-px, the relation was the inverse.
  • Linde, Peter, et al. (författare)
  • Accessibility and self-archiving of conference articles A study on a selection of Swedish institutional repositories
  • 2011
  • Ingår i: Information Services and Use. - IOS Press. - 0167-5265. - 978-1-61499-064-2 ; 31:3-4, s. 259-269
  • Tidskriftsartikel (refereegranskat)abstract
    • The main purpose of this project has been to examine the accessibility of refereed conference articles and the OA- and publishing policies of conferences in order to in this way elucidate different aspects concerning self-archiving in Swedish institutional repositories. For this purpose, the project participants have examined a number of conferences and references to conference articles via their institutional repositories during a specific time period and described these from the perspective of a common scheme. The study has showed that the local institutional repositories fill an important role to make conference publications visible. We have found that ca. 50% of the conference papers can be published as postprints in our institutional repositories. We have noticed that ca. 15% or the studied conference articles are not available at all. It is, therefore, of great importance to use local institutional repositories as a publishing channel, not only for primary published material such as dissertations and reports, but also as a source for finding these conference articles "without a home". Between 20-25% of the examined articles were found in some type of OA archive; ca. half of these were found in one of the project participants' own institutional repositories. This indicates that the publishing database of respective higher education institution is an important factor for open accessibility. Ca. 10% of the conferences in the study had an explicit OA policy or expressed such a policy by openly making conference articles accessible on their conference sites. A big problem when it comes to self-archiving of conference articles is the lack of information about OA policy. The landscape of conference publishing is complex and the self-archiving of documents from conferences is very time-consuming. Above all, we would wish a policy resource for conferences similar to the SHERPA/RoMEO. At present, however, there is no other alternative than scrutinizing the conferences' copyright information to the authors and from this attempt to draw conclusions about possible self-archiving. To facilitate the future handling and classification of conference articles in Swedish institutional repositories a number of recommendations are suggested.
  • Pecorari, Diane, et al. (författare)
  • English textbooks in parallel-language tertiary education
  • 2011
  • Ingår i: TESOL Quarterly. - 0039-8322. ; 45:2, s. 313-333
  • Tidskriftsartikel (refereegranskat)abstract
    • Tertiary education in many countries is increasingly bilingual, with English used in parallel with the national language, particularly as a reading language. This article describes the results of a survey of student attitudes toward, and reading practices regarding, English language textbooks. Over 1,000 students at three Swedish universities responded to a questionnaire asking about their experiences with English textbooks. Textbooks written in English were generally unpopular, and the perception was widespread that they placed a greater burden on students. However, respondents were divided about whether their reading behavior and their learning outcomes were affected by having a textbook in English, and about whether English texts were desirable. The findings of this study have implications for teaching practices in contexts in which students are asked to read, or are being prepared to read, in a second language. Implications for the English as a foreign language or English as a second language classroom are discussed.
  • Anund, Anna, et al. (författare)
  • The effects of driving situation on sleepiness indicators after sleep loss : A driving simulator study
  • 2009
  • Ingår i: Industrial Health. - 0019-8366. ; 47:4, s. 393-401
  • Tidskriftsartikel (refereegranskat)abstract
    • Almost all studies of sleepy driving are carried out in driving simulators and with monotonous road conditions (no interaction with other cars). The present study investigated indicators of sleepy driving in a more challenging scenario after a night awake. 17 participants drove a high fidelity moving base driving simulator experiment while sleepiness was monitored physiologically and behaviourally. Short periods of situations of free driving (no other vehicles) alternated with short periods of following another vehicle (car following) with and without the possibility to overtake. The result showed that a night of prior sleep loss increased sleepiness levels at the wheel (eye closure duration and lateral variability) compared to after a night of normal sleep. Blink duration while overtaking was significantly lower compared to the other situations, it was at the same level as after night sleep. Speed when passing a stopped school bus was not significantly affected by sleepiness. However the warning caused a more rapid reduction of speed. In conclusion, a moderately challenging driving contest did not affect sleepiness indicators, but a very challenging one did so (overtaking). This suggests that it is important to monitor the driving situation in field operational tests of sleepy driving.
  • Hallvig, David, et al. (författare)
  • Sleepy driving on the real road and in the simulator - A comparison
  • 2013
  • Ingår i: Accident Analysis and Prevention. - 0001-4575. ; 50, s. 44-50
  • Tidskriftsartikel (refereegranskat)abstract
    • This study compared real driving with driving in a high fidelity, moving base, driving simulator with respect to driving performance, sleep related physiology (using electroencephalography and electrooculography) and subjective sleepiness during night and day driving for 10 participants.Sleepiness has been identified as one of the most important factors contributing to road crashes. However, almost all work on the detailed changes in behavior and physiology leading up to sleep related crashes has been carried out in driving simulators. It is not clear, however, to what extent simulator results can be generalized to real driving.The real road was emulated in the simulator. The results show that the simulator was associated with higher levels of subjective and physiological sleepiness than real driving. However, both for real and simulated driving, the response to night driving appears to be rather similar for subjective sleepiness and sleep physiology. Lateral variability was more responsive to night driving in the simulator, while real driving at night involved a movement to the left in the lane and a reduction of speed, both of which effects were absent in the simulator. It was concluded that the relative validity of simulators is acceptable for many variables, but that in absolute terms simulators cause higher sleepiness levels than real driving. Thus, generalizations from simulators to real driving must be made with great caution.
  • Lindskog, C., et al. (författare)
  • The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling
  • 2015
  • Ingår i: BMC Genomics. - 1471-2164. ; 16
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: To understand cardiac and skeletal muscle function, it is important to define and explore their molecular constituents and also to identify similarities and differences in the gene expression in these two different striated muscle tissues. Here, we have investigated the genes and proteins with elevated expression in cardiac and skeletal muscle in relation to all other major human tissues and organs using a global transcriptomics analysis complemented with antibody-based profiling to localize the corresponding proteins on a single cell level. Results: Our study identified a comprehensive list of genes expressed in cardiac and skeletal muscle. The genes with elevated expression were further stratified according to their global expression pattern across the human body as well as their precise localization in the muscle tissues. The functions of the proteins encoded by the elevated genes are well in line with the physiological functions of cardiac and skeletal muscle, such as contraction, ion transport, regulation of membrane potential and actomyosin structure organization. A large fraction of the transcripts in both cardiac and skeletal muscle correspond to mitochondrial proteins involved in energy metabolism, which demonstrates the extreme specialization of these muscle tissues to provide energy for contraction. Conclusions: Our results provide a comprehensive list of genes and proteins elevated in striated muscles. A number of proteins not previously characterized in cardiac and skeletal muscle were identified and localized to specific cellular subcompartments. These proteins represent an interesting starting point for further functional analysis of their role in muscle biology and disease.
  • Perman, JC, et al. (författare)
  • The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction.
  • 2011
  • Ingår i: The Journal of clinical investigation. - 1558-8238. ; 121:7, s. 2625-40
  • Tidskriftsartikel (refereegranskat)abstract
    • Reduced oxygen availability promotes triglyceride accumulation in hearts (1) and cardiomyocytes (2). Although it is well established that lipid accumulation in hypoxic conditions can be at least partly explained by a metabolic shift from oxidation of glucose and fatty acids to glycolysis (3, 4), it is not clear whether these metabolic changes alone are sufficient or if there is also a requirement for increased uptake of lipids. Potential mechanisms for lipid uptake include receptor-mediated endocytosis of lipoproteins, lipoprotein lipase–catalyzed (LPL-catalyzed) hydrolysis of triglycerides (5), and protein-facilitated uptake of fatty acids (reviewed in ref. 6). Accumulation of triglycerides in the myocardium is associated with impaired cardiac function (7–10), but it is not known whether there is a causative link between these 2 phenomena. Intracellular triglycerides, which are stored in the hydrophobic core of lipid droplets and surrounded by amphipathic lipids and proteins (reviewed in ref. 11), are most likely very inert and thus not directly lipotoxic (12). However, it is possible that products formed during the degradation of triglycerides, such as diglycerides and fatty acids, and ceramides, which are formed from fatty acids, may have a pronounced effect on myocardial function and survival. Hypoxia/ischemia is also known to promote ER stress or the unfolded protein response. This response involves the production of chaperones to promote the folding process and maintain ER homeostasis, but unresolved ER stress leads to apoptotic cell death (reviewed in refs. 13, 14). Recent evidence suggests that ER stress plays an important role in the progression of cardiovascular diseases including ischemic heart disease, indicating that strategies to reduce ER stress may be beneficial in the ischemic heart (15). The aims of this investigation were to clarify the mechanisms behind the accumulation of lipids in the myocardium during ischemia and to determine the effect of lipid accumulation on survival following an acute myocardial infarction. We show that hypoxia/ischemia increased expression of the VLDL receptor (VLDLR) in HL-1 cardiomyocytes and mouse hearts, and that expression of the VLDLR was essential for lipid accumulation during hypoxia/ischemia. Furthermore, VLDLR mRNA expression was higher in ischemic versus nonischemic human hearts. Importantly, survival was increased and infarct size, ER stress, and apoptosis were reduced in Vldlr–/– compared with Vldlr+/+ mice following an induced myocardial infarction. We also demonstrated that blockade of the VLDLR with antibodies reduced ischemia-induced lipid accumulation, ER stress, and apoptosis in mouse heart tissue. We therefore propose that the VLDLR-induced lipid accumulation in the ischemic heart worsens survival by increasing ER stress and apoptosis.
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