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Sökning: swepub > Karlstads universitet > (1995-1999) > Övrigt vetenskapligt

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  • Ullén, Anders, et al. (författare)
  • Twenty years with monoclonal antibodies. State of the art. Where do we go? : review
  • 1996
  • Ingår i: Acta Oncologica 1996;35:259-265.
  • Tidskriftsartikel (övrigt vetenskapligt)abstract
    • In this review, we have selected some parameters with the potential to improve the efficacy of RIL and RIT. Focus has partially been on the behaviour of radiolabelled antibodies in vivo in relation to properties and amounts of both target antigen and the antibodies used. If, out of the 28 factors listed in Table 1, some should be given preference in future work, it is our opinion that after the initial saturation of the tumour site a rapid decrease in redundant antibody is of significant importance. Furthermore, quantitative aspects of both antigens and antibodies should be more carefully evaluated when possible. By combining several of the listed approaches toward increasing efficiency, a more extensive use of RIL and RIT could be expected in the future.
  • Forsberg, T., et al. (författare)
  • Process orientation : the Swedish experience
  • 1999
  • Ingår i: Total Quality Management and Business Excellence. - 1478-3363. ; 10:45, s. 540-547
  • Tidskriftsartikel (övrigt vetenskapligt)
  • Berglund, Anna-Lena (författare)
  • A holistic view of urinary stress incontinence in women
  • 1995
  • Doktorsavhandling (övrigt vetenskapligt)abstract
    • The present study group consists of 45 women with genuine stress incontinence who were selected for surgical treatment and randomized either to retropubic urethrocystopexy (n=30) or pubococcygeal repair (n=15). The preoperative assessment included medical history, gynecological examination, urine analysis and culture, residual urine, pad test, frequency-continence charts, water urethrocystoscopy, continence test and cystometry with analysis of micturition. Moreover, five semistructured interviews were performed with the women and two with their partner. The following questionnaires were used measuring a) personality characteristics: Karolinska Scales of Personality (KSP), Eysenck Personality Inventory (EPI), b) depression: Beck Depression Inventory (BDI) and c) social support: Interview Schedule for Social Interaction (ISSI).The results have shown that there was no difference in the subjective cure rate between the two surgical methods (73% vs. 80 % respectively). The bladder volume had increased in both groups and the intravesical pressure of the bladder filled to maximum had increased in the pubococcygeal repair group. Other urodynamic variables were unchanged by the operation. Pad tests have demonstrated that 67 % of the women in the urethrocystopexy group and 47 % in the pubococcygeal repair group ceased to leak urine. Postoperatively, 63 % of the women in the urethrocystopexy group needed high doses of analgesics compared with only 33 % in the pubococcygeal repair group. Among the women experiencing severe to very severe pain dysphoric subjects were overrepresented. Postoperative residual urine was a minor nursing problem in both groups.Women with SUI of long duration scored significantly higher than controls on the KSP scales of somatic anxiety, psychic anxiety, psychasthenia, suspicion and on the EPI lie-scale. There was no significant difference in sexual activity before and after surgery. One or two sexual dysfunctions within the desire, excitement, orgasmic and resolution phase were reported by the majority of women both before and after surgical intervention.The cured women reported a higher level of overall activities before surgery than the improved (i.e. not cured) women, whereas post surgery both the cured and the improved women obtained about the same level of activities. Regarding social support, no differences between the cured or improved women occured as concerns attachment. The cured women showed a higher degree of adequacy of social integration compared with the improved women.In order to delineate predictive factors for the surgical outcome the following variables were investigated: age of patient, duration of urine leakage, parity, personality, psychological and social factors. The following predictors of the outcome of surgical treatment emerged: duration of stress incontinence, neuroticism and age of patient.The results of the present study indicate the ecessity of a multidisciplinary approach to the treatment and nursing of women with SUI.
  • Bjurklo, Margareta, 1946-, et al. (författare)
  • Nyckelord : en nyckel vid kompetensutveckling
  • 1998
  • Doktorsavhandling (övrigt vetenskapligt)abstract
    • Qualification is the competence that is required for tasks related to wage labour. Competence is all the forms of knowledge possessed by the staff as well as their personal abilities. When qualification is related to competence, possible competence deficiencies become apparent. The first step in the process of describing competence deficiency is to specify the concept of qualification. This is achieved by means of Õsocial testsÕ, which may be considered as relevant data for controlling the improvement of competence. Empirical data are used to develop Õsocial testsÕ relating to qualification for two staff categories
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