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Distinctive pattern...
Distinctive pattern of c-fos expression in the feline cervico-lumbar spinal cord after stimulation of vanilloid receptors in dorsal neck muscles
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- Kalezic, Ivana (författare)
- Högskolan i Gävle,Umeå universitet,Idrottsmedicin,Belastningsskadecentrum
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Pilyavskii, AI (författare)
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Maisky, VA (författare)
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- Kostyukov, AI (författare)
- Högskolan i Gävle,Belastningsskadecentrum
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- Windhorst, U (författare)
- Högskolan i Gävle,Belastningsskadecentrum
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- Johansson, H (författare)
- Högskolan i Gävle,Belastningsskadecentrum
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(creator_code:org_t)
- Amsterdam : Elsevier Science, 2004
- 2004
- Engelska.
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Ingår i: Neuroscience Letters. - Amsterdam : Elsevier Science. - 0304-3940 .- 1872-7972. ; 364:2, s. 94-97
- Relaterad länk:
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http://www.ncbi.nlm....
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visa fler...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- In the present study, c-fos expression in the spinal cord has been used as a marker of neuronal activation induced by capsaicin-sensitive sensory afferents from the dorsal neck muscles in cats (n = 6). The number of Fos-immunoreactive neurons, which were revealed using the avidin-biotin-peroxidase method, was significantly increased in the cervical and lumbar spinal cord. In contrast to the control group (n = 3), 2 h after intramuscular capsaicin injection, c-fos expression was more extensive ipsilaterally to the injected side in the C3-C6 segments, and bilaterally in the L4-L6 segments. Most labeled neurons in the cervical spinal cord were small and giant cells, predominantly located in the middle and lateral parts of lamina I and, additionally, at the neck of the dorsal horn (lamina V), i.e., within the zones of termination of high-threshold muscle afferents. The widespread distribution of labeled cells throughout the cervical cord within the intermediate zone (lamina VII) coincided with the sites of last-order premotor interneurons and cells of origin of long crossed and uncrossed descending propriospinal pathways to the lumbar spinal cord. These findings suggest possible mechanisms for spreading of nociceptive signals between cervical and lumbar regions.
Nyckelord
- Animals
- Capsaicin/administration & dosage/pharmacology
- Cats
- Cell Size
- Cervical Vertebrae
- Female
- Genes; fos/*genetics
- Histocytochemistry
- Injections
- Lumbar Vertebrae
- Male
- Neck Muscles/innervation/metabolism/*physiology
- Neural Pathways/physiology
- Pain/physiopathology
- Receptors; Drug/*agonists
- Spinal Cord/*metabolism
- Stimulation; Chemical
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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