- Adolfsson, Jan, et al.
Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12
Ingår i: Nature Genetics. - London : Nature Publishing Group. - 1061-4036. ; 40:10, s. 1153-1155
Tidskriftsartikel (övrigt vetenskapligt)abstract
- We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, <img src="http://www.nature.com/__chars/math/special/sim/black/med/base/glyph.gif" />26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 <img src="http://www.nature.com/__chars/math/special/times/black/med/base/glyph.gif" /> 10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.