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- Hagfors, Linda, 1974-
(författare)
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A Mediterranean dietary intervention study of patients with rheumatoid arthritis
- 2003
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Case control studies have shown that a high consumption of fish, olive oil, and cooked vegetables is associated with a decreased risk of developing rheumatoid arthritis (RA). These foods have a central position in the traditional Cretan Mediterranean diet, and it has been suggested that dietary factors contribute to the low prevalence of RA in Mediterranean countries. The overall aim of this thesis was to examine whether a modified Cretan Mediterranean diet can reduce signs and symptoms of RA. This was investigated in a three-month dietary intervention trial in which 51 patients with well controlled, although active RA of at least two years duration took part. A further aim was to study the compliance with the experimental and control diets used in the study, and to validate the diet history interview method used to assess the dietary intake. The validation was carried out by means of biological markers of dietary intake. From baseline to the end of the study the group that had adopted the Cretan Mediterranean diet (MD group; n=26) obtained a reduction in disease activity, improved physical function, and improved vitality, while no changes was seen in the control diet group (CD group; n=25). According to the dietary assessments, the intake frequencies of antioxidant-rich food items increased in the MD group. This group also had a significantly higher intake of vitamin E, vitamin C and selenium compared to the CD group. Despite the reported increase in the consumption frequencies of antioxidant-rich foods, the plasma levels of carotenoids, vitamin C, lipid adjusted tocopherols, uric acid and urine malondialdehyde, a marker of oxidative stress, were unchanged at the end of the study. The plasma levels of retinol, vitamin C and uric acid were, however, correlated to indices of disease activity. Changes in the reported consumption of food groups with relevance to the fat intake were also observed in the MD group, including an increased intake of fish, shellfish and poultry, and a decreased intake of meat and high fat dairy products. As a result, the total fat intake was lower in the MD group compared to the CD group. Furthermore, in the MD group a slightly higher percentage of the energy intake was derived from polyunsaturated fatty acids and a lower percentage from saturated fatty acids. This group also had a lower ratio of n-6:n-3 fatty acids. A corresponding change in the relation between n-6 and n-3 fatty acids was also observed in s-phospholipids. The validation of the diet history interview method showed that the diet history interview could capture the dietary intake fairly well. The validity of the reported dietary intake did not differ between the MD and the CD group, which indicates that the dietary assessment was not biased by the dietary intervention.
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| 2. |
- Hagfors, Linda, 1974-, et al.
(författare)
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Antioxidant intake, plasma antioxidants and oxidative stress in a randomized, controlled, parallel, Mediterranean dietary intervention study on patients with rheumatoid arthritis
- 2003
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Ingår i: Nutrition Journal. - : Springer Science and Business Media LLC. - 1475-2891. ; 2:5
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Tidskriftsartikel (refereegranskat)abstract
- Background: Previously we have reported that patients with rheumatoid arthritis (RA) obtained a significant reduction in disease activity by adopting a Mediterranean-type diet. The present study was carried out to investigate the antioxidant intake, the plasma levels of antioxidants and a marker of oxidative stress (malondialdehyde) during the study presented earlier. Methods: RA patients randomized to either a Mediterranean type diet (MD group; n = 26) or a control diet (CD group; n = 25) were compared during a three month dietary intervention study. Their antioxidant intake was assessed by means of diet history interviews and their intake of antioxidant-rich foods by a self-administered questionnaire. The plasma levels of retinol, antioxidants (α- and γ-tocopherol, β-carotene, lycopene, vitamin C and uric acid) and urinary malondialdehyde (MDA), a marker for oxidative stress, were determined using high performance liquid chromatography. The Student's t-test for independent samples and paired samples were used to test differences between and within groups. For variables with skewed distributions Mann-Whitney U-test and Wilcoxon signed ranks test were performed. To evaluate associations between dietary intake of antioxidants, as well as between disease activity, MDA and antioxidants we used Pearson's product moment correlation or Spearman's rank correlation. Results: The MD group had significantly higher intake frequencies of antioxidant-rich foods, and also higher intakes of vitamin C (p = 0.014), vitamin E (p = 0.007) and selenium (p = 0.004), and a lower intake of retinol (p = 0.049), compared to the CD group. However, the difference between the groups regarding vitamin C intake was not significant when under- and over-repoters were excluded (p = 0.066). There were no changes in urine MDA or in the plasma levels of antioxidants (after p-lipid adjustments of the tocopherol results), from baseline to the end of the study. The levels of retinol, vitamin C and uric acid were negatively correlated to disease activity variables. No correlation was found between antioxidant intake and the plasma levels of antioxidants. Conclusions: Despite an increase in reported consumption of antioxidant-rich foods during the Mediterranean diet intervention, the levels of plasma antioxidants and urine MDA did not change. However, the plasma levels of vitamin C, retinol and uric acid were inversely correlated to variables related to RA disease activity.
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| 4. |
- Hedlund, Sven-Olof, et al.
(författare)
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A retrospective study of pre-fabricated carbon fibre root canal posts.
- 2003
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Ingår i: Journal of Oral Rehabilitation. - 1365-2842. ; 30:10, s. 1036-40
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Tidskriftsartikel (refereegranskat)abstract
- Although pre-fabricated carbon fibre posts have been used during the past decade clinical evaluations of the technique are still few. Using dental records and radiographs the clinical performance of 65 pre-fabricated carbon fibre posts (Composipost and Endopost) placed in 48 patients who regularly visited a general practice were evaluated in the present study. After an average time of 2.3 +/- 0.8 years (median 2.1 years, range 1-4.9 years) of clinical service the failure rate was 3%. Failure occurred in one tooth with a single crown restoration and in one tooth that was part of a cantilever fixed partial denture. Although the failure rate is lower than those mostly reported for metallic posts and cores more clinical studies are necessary to assess the suitability of pre-fabricated carbon fibre posts for routine use as an alternative to individually cast posts.
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| 5. |
- Hedlund, Sven-Olof, et al.
(författare)
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Retention of prefabricated and individually cast root canal posts in vitro.
- 2003
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Ingår i: British Dental Journal. - 0007-0610 .- 1476-5373. ; 195:3, s. 155-158
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The aim of the study was to evaluate the retention of prefabricated root canal posts made of a variety of materials that have recently been introduced into dentistry. Materials and methods: The posts studied were CosmoPost, Composipost carbon fibres, Composipost Æstheti-Plus, Composipost Light-Post, and Para Post Fiber White. The posts were luted in extracted human premolars and the cores were built up with the resin composites recommended by the manufactures. The retention of individually cast gold alloy posts luted with zinc-phosphate cement were used as reference. A universal testing machine was used to determine the retention of each cemented post. Data were compared using ANOVA supplemented with Fisher’s PLSD at a significance level of p < 0.05. Results: Only the CosmoPost system exhibited retention values that were significantly lower then for the conventionally cast gold alloy posts luted with zinc-phosphate cement. The force necessary to loosen the CosmoPost specimens was significantly less than that needed to loosen the Composipost Æstheti-Plus (p < 0.05) and the Composipost Light-Post systems (p < 0.001). The force necessary to loosen the Para Post Fiber White specimens was significantly less than for the Composipost Light-Post system (p < 0.01). Other combinations did not differ significantly (p > 0.05). Conclusions: When zirconium oxide ceramic posts are luted with resin composites the bonding between the ceramic and resin composite seems to be weak. Further studies are thus necessary to achieve improved retention of all-ceramic root canal posts.
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| 10. |
- Larsson, Christel, 1972-, et al.
(författare)
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Food habits of young Swedish and Norwegian vegetarians and omnivores
- 2001
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Ingår i: Public Health Nutrition. - 1368-9800 .- 1475-2727. ; 4:5, s. 1005-1014
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To determine the prevalence of vegetarianism and compare food habits among vegetarian and omnivorous adolescents in Sweden and Norway. Design: Cross-sectional study by questionnaire in Sweden and Norway to gather information about food habits. Setting: The municipalities of Umeå and Stockholm in Sweden, and Bergen in Norway. Subjects: In total 2041 ninth-grade students (578 from Umeå, 504 from Stockholm and 959 from Bergen), mean age 15.5 years, were included. The response rate was 95% in Umeå, 91% in Stockholm and 83% in Bergen. Results: There was a significantly higher prevalence of vegetarianism in Umeå (15.6%) than in Stockholm (4.8%) and Bergen (3.8%). Vegetarians generally wanted more information about a healthy diet and vegetarian females ate dietary supplements to prevent deficiencies more often than omnivorous females (P < 0.01). The young male vegetarians more or less excluded animal products from their diet without changing their food frequency intake or modifying their dietary habits in other respects, while the young female vegetarians more often consumed vegetables and dietary supplements (P < 0.05). However, there was no difference between the intake of fruits/berries, alcoholic beverages, ice cream, sweets/chocolates and fast foods by vegetarians compared with omnivores. Conclusions: There were three to four times more vegetarians in Umeå than in Stockholm and Bergen. The food habits of the young vegetarians differed from those of omnivorous adolescents and also in some respects from previously published comparative studies of vegetarians' and omnivores' food habits. It is uncertain whether the health benefits shown in previous studies on vegetarianism will be experienced by this young generation of vegetarians.
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