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- Østergaard, Charlotte
(författare)
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Ethical dilemmas of stretching towards Others in fitting situations
- 2022
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Ingår i: Russian Fashion Theory. ; special issue on performance and clothing:66(3), s. 35-35
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- This article stretches the situatedness of costume fitting to include dressing and fitting into a connecting-costume in an urban environment. The author’s ambition is to study the ethical dilemmas that emerge in situations where participants are invited to fit into a costume that connects them to a co-wearer. Sara Ahmed writes that ‘bodies as well as objects shape though being orientated towards each other’ (Ahmed, 2010:245). This suggest that the object as the connecting-costume entanglement orientate the wearers towards each other and potentially towards different Others. However, in events and during specific situations the connecting-costume will most likely will expose and queer the wearers in an urban environment, hence the ethical dilemma is how does the researcher craft conditions in a way that makes the wearers fit-able to stretch themselves towards each other. One dilemma is that situating fitting in the urban environment suggests that several conditions most likely are out of the researcher’s control. Another dilemma is that even if the researcher also crafts the connecting-costume the question is if the researcher can predict or even imagine how the crafted materialities will craft wearers including how wearers fit one another? Eva Skærbæk writes about Løgstrup’s philosophy of the ethical demand that ‘ethics is the responsibility of I, the demand is personal’ (Skærbæk 2011:45). Skærbæk’s words suggest that research is an ethical call towards the researcher including that the researcher are responsible for what the research crafts. Hence, even if several conditions are out of the researcher’s control and event if the researcher cannot predict how the wearers respond to the conditions ¬– the researcher are responsible for how she craft conditions including that she in the specific situations must attend and respond to what the specific conditions crafts. This article argues that in order to create conditions for wearers to become fit-able to stretch themselves towards Others the researcher has ethical responsibility to have a critical awareness of the specificity of the situations. The researcher must critically be aware of, attend and respond to how the situation craft the wearers as well as that the researcher must learn from the responses of the wearers.
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| 4. |
- Astermark, Jan, et al.
(författare)
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Arandomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) Study.
- 2009
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Ingår i: Gematologiâ i Transfuziologiâ. - 0234-5730. ; 54:5, s. 35-35
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Tidskriftsartikel (refereegranskat)abstract
- Arandomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) Study. J. Astermark(1), Sh. M. Donfield(2), D. M. DiMichele(3), A. Gringeri(4), S. A. Gilbert(2), J. Waters(2), E. Berntorp(1), for the FENOC Study Group. Department for Hematology and Coagulation Disorders, Malmo, University Hospital, Malmo, Sweden(1); Department of Biostatistics, Rho, Chapel Hill, NC2; Department of Pediatrics, Weill Medical College, Cornell University, New York, NY3; Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan, Italy(4). The development of inhibitory antibodies to factor VIII is a serious complication of hemophilia. FEIBA (factor VIII inhibitorbypassing activity), an activated prothrombin complex concentrate (aPCC), and NovoSeven, recombinant factor Vila (rFVIIa), are used as hemostatic bypassing agents in treating patients with inhibitors. The FENOC study was designed to test equivalence of the products in the treatment of ankle, knee, and elbow joint bleeding. A prospective, open-label, randomized, crossover, equivalency design was used. The parameters of interest were the percentage of patients who reported efficacy in response to FEIBA and the percentage that reported efficacy in response to NovoSeven. A difference in these percentages of no more than 15% was determined to be a clinically acceptable magnitude for equivalence of the 2 products. The primary outcome was evaluation 6 hours after treatment. Data for 96 bleeding episodes contributed by 48 participants were analyzed. The criterion for declaring the 2 products equivalent at 6 hours was not met; however, the confidence interval of the difference in percentages of efficacy reported for each product only slightly exceeded the 15% boundary (11.4-15.7%); p = 0.059. FEIBA and NovoSeven appear to exhibit a similar effect on joint bleeds, although the efficacy between products is rated differently by a substantial proportion of patients. This trial was registered at www.clinicaltrials.gov.
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- Burova, L. A., et al.
(författare)
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Nephritogenic activity of IgA-binding streptococcus pyogenes : An experimental model of IgA glomerulonephritis
- 2016
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Ingår i: Medical Immunology (Russia). - 1563-0625. ; 18:3, s. 221-230
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Tidskriftsartikel (refereegranskat)abstract
- The aim of present study was to arrange an experimental rabbit model for IgA-nephropathy. To this purpose, an approach was attempted which was previously successfully applied in rabbits, aiming for induction of post-streptococcal glomerulonephritis (PSGN). To induce the nephropathy, we used two Streptococcus pyogenes strains of M4 and M60 serotypes which showed differential IgA-binding capacity mediated by the IgAFc microbial receptors. The renal tissue damage was developed in most animals treated with emm60 S. pyogenes characterized by marked IgAFcR expression and higher IgA-binding ability. By means of morphometric analysis. Significant morphological and immunochemical glomerular changes were revealed in 6/10 rabbits, as follows: (i) massive IgA deposition in the mesangial glomerular cells, atrophy of the capillary net, and tissue oedema; (ii) marked C3-complement deposition in proximal and distal tubules; (iii) a significant infiltration of cortical and medullar areas by lymphocytes associated with weak TNFα production. Noteworthy, we did not observe local IgG deposition in any cases, thus allowing to exclude any role of anti-IgG, or other IgG's in evolution of the pathology. Alternatively, the IgA-deposits may occur due to microbial IgA FcR-IgAcontaining cmplexes, as earlier shown by the Swedish scientists. The above tissue changes were completely absent in kidneys of control animals. Taken together, these data suggest that we have developed an experimental model similar to IgA-nephropathy in humans. The results also extend our knowledge on pathogenic effects of the IgA Fc-binding proteins of Streptococcus pyogenes.
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