| 1. |
- Berndt, Sonja I., et al.
(författare)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Tidskriftsartikel (refereegranskat)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 2. |
- Aad, G., et al.
(författare)
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- 2013
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Lagou, Vasiliki, et al.
(författare)
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Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
- 2021
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association study meta-analyses in individuals of European descent without diabetes. Here we report sex dimorphism in allelic effects on fasting insulin at IRS1 and ZNF12 loci, the latter showing higher RNA expression in whole blood in women compared to men. We also observe sex-homogeneous effects on fasting glucose at seven novel loci. Fasting insulin in women shows stronger genetic correlations than in men with waist-to-hip ratio and anorexia nervosa. Furthermore, waist-to-hip ratio is causally related to insulin resistance in women, but not in men. These results position dissection of metabolic and glycemic health sex dimorphism as a steppingstone for understanding differences in genetic effects between women and men in related phenotypes.
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| 4. |
- Abazov, V. M., et al.
(författare)
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Measurement of the ratios of the Z/gamma*+ >= n jet production cross sections to the total inclusive Z/gamma* cross section in p(p)over-bar collisions at root s=1.96 TeV
- 2008
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 658, s. 112-
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Tidskriftsartikel (refereegranskat)abstract
- We present a study of events with Z bosons and associated jets produced at the Fermilab Tevatron collider in p p collisions at a center of mass energy of 1.96 TeV The data sample consists of nearly 14000 Z/gamma* -> e(+)e(-) candidates corresponding to an integrated luminosity of 0.4 fb(-1) collected with the D circle divide detector. Ratios of the Z/gamma*+ >= n jet cross sections to the total inclusive Z/gamma* cross section have been measured for n = 1-4 jets, and found to be in good agreement with a next-to-leading order QCD calculation and with a tree-level QCD prediction with parton shower simulation and hadronization.
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| 5. |
- Abazov, V. M., et al.
(författare)
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Measurement of the t(t)over-bar production cross section in p(p)over-bar collisions at root s=1.96 TeV
- 2008
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 100:19:100, s. 192004-
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Tidskriftsartikel (refereegranskat)abstract
- We measure the t (t) over bar production cross section in p (p) over bar collisions at root s = 1.96 TeV in the lepton + jets channel. Two complementary methods discriminate between signal and background: b tagging and a kinematic likelihood discriminant. Based on 0.9 fb(-1) of data collected by the D0 detector at the Fermilab Tevatron Collider, we measure sigma(t (t) over bar) = 7.62 +/- 0.85 pb, assuming the current world average m(t) = 172.6 GeV. We compare our cross section measurement with theory predictions to determine a value for the top-quark mass of 170 +/- 7 GeV.
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| 6. |
- Abazov, V. M., et al.
(författare)
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Observation of the B-c meson in the exclusive decay B-c -> J/psi pi
- 2008
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 101:1, s. 012001-:101, s. 012001-
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Tidskriftsartikel (refereegranskat)abstract
- A fully reconstructed B-c -> J/psi pi signal is observed with the D0 detector at the Fermilab Tevatron p (p) over bar collider using 1.3 fb(-1) of integrated luminosity. The signal consists of 54 +/- 12 candidates with a significance that exceeds 5 standard deviations, and confirms earlier observations of this decay. The measured mass of the B-c meson is 6300 +/- 14(stat)+/- 5(syst) MeV/c(2).
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| 7. |
- Abazov, V. M., et al.
(författare)
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Search for W ' boson resonances decaying to a top quark and a bottom quark
- 2008
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 100:21, s. 211803-:100, s. 211803-
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Tidskriftsartikel (refereegranskat)abstract
- We search for the production of a heavy W ' gauge boson that decays to third generation quarks in 0: 9 fb(-1) of p (p) over bar collisions at root s = 1: 96 TeV, collected with the D0 detector at the Fermilab Tevatron collider. We find no significant excess in the final-state invariant mass distribution and set upper limits on the production cross section times branching fraction. For a left-handed W ' boson with SM couplings, we set a lower mass limit of 731 GeV. For right-handed W ' bosons, we set lower mass limits of 739 GeV if the W ' boson decays to both leptons and quarks and 768 GeV if the W ' boson decays only to quarks. We also set limits on the coupling of the W ' boson to fermions as a function of its mass.
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| 8. |
- Abazov, V. M., et al.
(författare)
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Search for W ' bosons decaying to an electron and a neutrino with the D0 detector
- 2008
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 100:3, s. 031804-:100, s. 031804-
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Tidskriftsartikel (refereegranskat)abstract
- This Letter describes the search for a new heavy charged gauge boson W-' decaying into an electron and a neutrino. The data were collected with the D0 detector at the Fermilab Tevatron p (p) over bar Collider at root s=1.96 TeV, and correspond to an integrated luminosity of about 1 fb(-1). Lacking any significant excess in the data in comparison with known processes, an upper limit is set on sigma(')(W)xB(W-'-> e nu), and a W-' boson with mass below 1.00 TeV can be excluded at the 95% C.L., assuming standard-model-like couplings to fermions. This result significantly improves upon previous limits and is the most stringent to date.
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| 9. |
- Abazov, V. M., et al.
(författare)
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Search for ZZ and z gamma* production in p(p)over-bar collisions at root s=1.96 TeV and limits on anomalous ZZZ and ZZ gamma* couplings
- 2008
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 100:13, s. 131801-:100, s. 131801-
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Tidskriftsartikel (refereegranskat)abstract
- We present a study of mu mu mu mu, eeee, and mu mu ee events using 1 fb(-1) of data collected with the D0 detector at the Fermilab Tevatron p (p) over bar Collider at root s = 1.96 TeV. Requiring the lepton pair masses to be greater than 30 GeV, we observe one event, consistent with the expected background of 0.13 +/- 0.03 events and with the predicted standard model ZZ and Z gamma(*) production of 1.71 +/- 0.15 events. We set an upper limit on the ZZ and Z gamma(*) cross section of 4.4 pb at the 95% C.L. We also derive limits on anomalous neutral trilinear ZZZ and ZZ gamma(*) gauge couplings. The one-parameter 95% C.L. coupling limits with a form-factor scale Lambda = 1.2 TeV are -0.28 < f(40)(Z)< 0.28, -0.31 < f(50)(Z)< 0.29, -0.26 < f(40)(gamma)< 0.26, and -0.30 < f(50)(gamma)< 0.28.
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| 10. |
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