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Träfflista för sökning "WFRF:(Dabelsteen Erik) ;pers:(Dabelsteen Erik);pers:(Sjöström Björn)"

Sökning: WFRF:(Dabelsteen Erik) > Dabelsteen Erik > Sjöström Björn

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  • Thurfjell, Niklas, et al. (författare)
  • Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck.
  • 2005
  • Ingår i: Advances in Oto-Rhino-Laryngology. - 0065-3071. ; 62, s. 49-57
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND/AIMS: Squamous cell carcinoma of the head and neck (HNSCC) is the 6th most common malignancy worldwide with a 5-year survival that has not improved over the last 20-25 years. Factors of prognostic significance for this tumour type include the presence of regional lymph node metastasis and amplification of chromosome 3q21-29, where the p63 gene is located. This gene encodes 6 proteins and is crucial for formation of the oral mucosa, teeth, salivary glands and skin. Each of the 6 different p63 proteins has different characteristics and functions, where some resemble the tumour suppressor protein p53, whilst others have functions that oppose p53. METHODS: To understand the function and importance of p63 in oral mucosa and tumour development we have studied protein as well as mRNA expression in normal oral mucosa and tumours. RESULTS/CONCLUSION: Expression of p63 proteins differs between the cell layers in normal oral mucosa, and primary HNSCC has a high expression level of p63 isoforms normally expressed in basal cells. Data suggest that p63 expression in HNSCC influences tumour cell differentiation.
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