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- Arvidsson, Ida, et al.
(author)
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Detection of left bundle branch block and obstructive coronary artery disease from myocardial perfusion scintigraphy using deep neural networks
- 2021
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In: Medical Imaging 2021 : Computer-Aided Diagnosis - Computer-Aided Diagnosis. - : SPIE. - 1605-7422. - 9781510640238 ; 11597
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Conference paper (peer-reviewed)abstract
- Myocardial perfusion scintigraphy, which is a non-invasive imaging technique, is one of the most common cardiological examinations performed today, and is used for diagnosis of coronary artery disease. Currently the analysis is performed visually by physicians, but this is both a very time consuming and a subjective approach. These are two of the motivations for why an automatic tool to support the decisions would be useful. We have developed a deep neural network which predicts the occurrence of obstructive coronary artery disease in each of the three major arteries as well as left bundle branch block. Since multiple, or none, of these could have a defect, this is treated as a multi-label classification problem. Due to the highly imbalanced labels, the training loss is weighted accordingly. The prediction is based on two polar maps, captured during stress in upright and supine position, together with additional information such as BMI and angina symptoms. The polar maps are constructed from myocardial perfusion scintigraphy examinations conducted in a dedicated Cadmium-Zinc-Telluride cardio camera (D-SPECT Spectrum Dynamics). The study includes data from 759 patients. Using 5-fold cross-validation we achieve an area under the receiver operating characteristics curve of 0.89 as average on per-vessel level for the three major arteries, 0.94 on per-patient level and 0.82 for left bundle branch block.
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| 5. |
- Carlsson, Fredrik, 1974-, et al.
(author)
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Increased CO2 evolution caused by heat treatment in wood-decaying fungi
- 2017
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In: Mycological progress. - : Springer Science and Business Media LLC. - 1617-416X .- 1861-8952. ; 16:5, s. 513-519
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Journal article (peer-reviewed)abstract
- Wood-decaying fungi are regarded as the main decomposers of woody debris in boreal forests. Given that fungal respiration makes a significant contribution to terrestrial carbon flows, it is important to understand how the wood-decaying fungal metabolism is regulated in relation to different environmental conditions and disturbances. In the present study, we investigated the effect of temperature stress on wood decomposition rate in 18 species of wood-decaying fungi, representing a broad range of species-habitat associations. Heat shock duration and temperature were calibrated to match the conditions of a forest fire. We found a general increase in fungal decay rate after heat shock; the response was more pronounced in species associated with fire-prone forests. The underlying mechanism is unclear, but possibly relates to an up-regulation at the cellular level in response to heat shock. Our results show that the decomposition rate of dead wood can be strongly affected by environmental triggers.
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| 6. |
- Carta, Manolo, et al.
(author)
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The serotonergic system in L-DOPA-induced dyskinesia : pre-clinical evidence and clinical perspective
- 2018
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In: Journal of Neural Transmission. - : Springer Science and Business Media LLC. - 0300-9564 .- 1435-1463. ; 125:8, s. 1195-1202
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Journal article (peer-reviewed)abstract
- During the last decade, the serotonergic system has emerged as a key player in the appearance of L-DOPA-induced dyskinesia in animal models of Parkinson’s disease. Clinical investigations, based on imaging and postmortem analyses, suggest that the serotonin neurons are also involved in the etiology of this complication of long-term L-DOPA treatment in parkinsonian patients. These findings have stimulated efforts to develop new therapies using drugs targeting the malfunctioning serotonin neurons. In this review, we summarize the experimental and clinical data obtained so far and discuss the prospects for further development of this therapeutic strategy.
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Five Professors on Education and Democracy : Inaugural Lectures 1999-2003
- 2004
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Editorial collection (other academic/artistic)abstract
- This report brings together the inaugural lectures of the five professors at the Department of Education, Örebro University, from 1999 to 2003. The main aim of the collection is to show how a common interest in the relationship between education and democracy has united all these professors and created a specific environment for educational research. In the first lecture by Tomas Englund, from 1999, two strands of educational research are stressed, didactic research and philosophy of education. Members of the research group Education & Democracy are said to be united in a belief in education as an important and potentially significant force in the achievement of democracy, and the possible development of a deliberative attitude in education is underlined. Agneta Linné, who was appointed professor of education and didactic research in 2002, explores in her lecture education as a scientific discipline, using the concepts time and history, pedagogical space, narrative identity and narrative imagination. She raises the question of narrative perspectives and biography as potential tools for research on democratic dimensions of education. Bernt Gustavsson, made professor of education with a focus on democracy in 2002, analyses the never ending problem of the relation between the universal, for instance human rights as possible values for all, and the particular, in the form of the right of local communities and identities to their culture on the basis of recognition of difference. He underlines the potential of the hermeneutic tradition and how “bildung” may mediate between the universal and the particular. Gert Biesta, guest professor from 2001, argues in his lecture that we should understand democracy not only as a problem for education, but also as an educational problem in its own right. He proposes an educational definition of democracy as the situation in which all human beings can be subjects. Finally, Lars Løvlie, guest professor 2003–2004, also refers to the “bildung” concept, but introduces the concept of the body into what he calls “cyberbildung”, which does not break entirely with traditional aspects of “bildung”, but may even contribute to them. According to the phenomenological approach he sketches, there are no hard and fast walls between belonging to different worlds and being situated.
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| 10. |
- Folkow, Peter D., et al.
(author)
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Time domain Green functions for the homogeneous Timoshenko beam
- 1996
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Reports (other academic/artistic)abstract
- In this paper, wave splitting technique is applied to a homogeneous Timoshenko beam. The purpose is to obtain a diagonal equation in terms of the split fields. These fields are calculated in the time domain from an appropriate set of boundary conditions. The fields along the beam are represented as a time convolution of Green functions with the excitation. The Green functions do not depend on the wave fields but only on the parameters of the beam. Green functions for a Timoshenko beam are derived, and the exponential behaviour of these functions as well as the split modes are discussed. A transformation that extracts the exponential part is performed. Some numerical examples for various loads are presented and compared with results appearing in the literature.
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