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Numrering	Referens	Omslagsbild	Hitta
1.	Grote, Verena A., et al. (författare) The association of circulating adiponectin levels with pancreatic cancer risk: A study within the prospective EPIC cohort 2012 Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 130, s. 2428-2437 Tidskriftsartikel (refereegranskat)abstract Excess body weight and type 2 diabetes mellitus, risk factors of pancreatic cancer, are characterized by decreased levels of adiponectin. In addition to anti-inflammatory and anti-proliferative actions, adiponectin has an important role in regulating glucose metabolism, i.e., decreasing circulating blood glucose levels. Prospectively, hyperglycemia has been associated with risk of pancreatic cancer. The aim of this study was to investigate the association of pre-diagnostic adiponectin levels with pancreatic cancer risk. We conducted a case-control study nested within European Prospective Investigation into Cancer and Nutrition. Blood samples of 452 pancreatic cancer cases and 452 individually matched controls were analyzed by immunoassays. Multivariate conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Overall, adiponectin showed no association with pancreas cancer risk; however, among never smokers, higher circulating levels of adiponectin were associated with a reduction in pancreatic cancer risk (OR = 0.44 [95% CI 0.23-0.82] for highest vs. lowest quartile), whereas among current smokers there was no significant association (OR = 1.59 [95% CI 0.67-3.76] for highest vs. lowest quartile; p-trend = 0.530; p-interaction = 0.309). In our study, lower adiponectin concentrations may be associated with the development of pancreatic cancer among never smokers, whereas the only other prospective study being conducted so far showed a decrease in risk among male smokers. Therefore, further studies are needed to clarify the role of adiponectin in pancreatic cancer development. © 2011 UICC.
2.	Leufkens, Anke M, et al. (författare) Cigarette smoking and colorectal cancer risk in the European prospective investigation into cancer and nutrition study 2011 Ingår i: Clinical Gastroenterology and Hepatology. - : Elsevier BV. - 1542-3565 .- 1542-7714. ; 9:2, s. 137-144 Tidskriftsartikel (refereegranskat)abstract Ever smokers have an increased risk of colon cancer, which appeared to be more pronounced in the proximal than the distal colon location.
3.	Huerta, José María, et al. (författare) Prospective study of physical activity and risk of primary adenocarcinomas of the oesophagus and stomach in the EPIC (European Prospective Investigation into Cancer and nutrition) cohort. 2010 Ingår i: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 0957-5243 .- 1573-7225. ; 21:5, s. 657-669 Tidskriftsartikel (refereegranskat)abstract Overall and distal (non-cardia) gastric tumours were inversely associated with time spent on cycling and sports and a total PA index. No association was found for any type of PA and risk of cardia cancers of the stomach.
4.	Al-Zoughool, Mustafa, et al. (författare) Risk of endometrial cancer in relationship to cigarette smoking : Results from the EPIC study. 2007 Ingår i: International Journal of Cancer. - 1097-0215. ; 121:12, s. 2741-7 Tidskriftsartikel (refereegranskat)
5.	Rohrmann, Sabine, et al. (författare) Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European prospective investigation into cancer and nutrition 2011 Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 20:10, s. 2174-2182 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: Insulin-like growth factor-1 (IGF-I) is important in normal brain development but in the adult brain, IGF-I overexpression may be a risk factor for tumor development. METHODS: We examined the association between circulating concentrations of IGF-I and IGFBP-3 in relation to risk of gliomas (74 low-grade, 206 high-grade gliomas), meningiomas (n = 174) and acoustic neuromas (n = 49) by using a case-control design nested in the European Prospective Investigation into Cancer and Nutrition. IGF-I and IGFBP-3 were measured by ELISAs.Conditional logistic regression was used to compute ORs and corresponding 95% CIs. RESULTS: The risk of low-grade gliomas was elevated with increased IGF-I (OR = 3.60, 95% CI: 1.11-11.7; top vs. bottom quartile) and decreased with elevated IGFBP-3 concentrations (OR = 0.28, 95% CI: 0.09-0.84) after mutual adjustment of these two factors; these results became nonsignificant after exclusion of the first year of follow-up. No association was observed for high-grade gliomas or meningiomas. Both high IGF-I and IGFBP-3 concentrations were associated with risk of acoustic neuromas (IGF-I: OR = 6.63, 95% CI: 2.27-19.4, top vs. bottom tertile; IGFBP-3: OR = 7.07, 95% CI: 2.32-21.6), even after excluding the first year of follow-up. CONCLUSION: High concentrations of IGF-I might be positively associated with risk of low-grade gliomas and acoustic neuromas, although we cannot exclude reverse causation, in particular for low-grade gliomas. Impact: Factors of the IGF axis might be involved in the etiology of some types of brain tumors. Cancer Epidemiol Biomarkers Prev; ©2011 AACR.

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Typ av publikation: tidskriftsartikel (5)

Typ av innehåll: refereegranskat (5)

Författare/redaktör: Tjønneland, Anne (5)Ta bort avgränsningen; Overvad, Kim (5); Kaaks, Rudolf (5); Boeing, Heiner (5); Trichopoulou, Antoni ... (5); Mattiello, Amali... (5)Ta bort avgränsningen; visa fler...; Tumino, Rosario (5); Chirlaque, Maria-Dol ... (5); Khaw, Kay-Tee (5); Riboli, Elio (5); Palli, Domenico (5); Trichopoulos, Dimitr ... (5); Boutron-Ruault, Mari ... (4); Clavel-Chapelon, Fra ... (4); Lagiou, Pagona (4); Rohrmann, Sabine (3); Lund, Eiliv (3); Olsen, Anja (3); Manjer, Jonas (3); Agudo, Antonio (3); Ardanaz, Eva (3); Jenab, Mazda (3); Rinaldi, Sabina (3); Vineis, Paolo (3); Bueno-de-Mesquita, H ... (3); Peeters, Petra H. M. (3); Dossus, Laure (3); Rodríguez, Laudina (3); Linseisen, Jakob (2); Peeters, Petra H (2); Sánchez, Maria-José (2); van Duijnhoven, Frän ... (2); Wareham, Nick (2); Key, Timothy J (2); Norat, Teresa (2); Gram, Inger T. (2); Boshuizen, Hendriek ... (2); Grioni, Sara (2); Larranaga, Nerea (2); Wareham, Nicholas J. (2); Hallmans, Göran (2); Allen, Naomi (2); Bas Bueno-de-Mesquit ... (2); Romaguera, Dora (2); Crowe, Francesca L (2); Molina-Montes, Esthe ... (2); Morois, Sophie (2); Lindkvist, Björn (2); Michaud, Dominique S (2); Stegger, Jakob (2); visa färre...

Lärosäte: Umeå universitet (5)Ta bort avgränsningen; Lunds universitet (3); Karolinska Institutet (2); Göteborgs universitet (1)

Språk: Engelska (5)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (3); Lantbruksvetenskap (1)

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