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- Bagazgoitia, N. V. D., et al.
(author)
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Quality of Life in Young Adults With Cerebral Palsy: A Longitudinal Analysis of the SPARCLE Study
- 2021
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In: Frontiers in Neurology. - : Frontiers Media SA. - 1664-2295. ; 12
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Journal article (peer-reviewed)abstract
- Introduction: While most people with cerebral palsy (CP) will have a life expectancy similar to that of the general population, international research has primarily focused on childhood and adolescence; and knowledge about the quality of life (QoL) of young adults with CP, its trajectories, and associated factors remains scarce.Methods: This longitudinal study included young adults with CP living in five European regions and who had previously participated in the SPARCLE cohort as children and/or adolescents. Their QoL in the psychological well-being and social relationships domains was estimated using age-appropriate validated instruments (KIDSCREEN-52 in childhood/adolescence and WHOQOL-Bref in young adulthood). We used generalized linear mixed-effect models with random intercept to estimate long-term trajectories of QoL in both domains and to investigate whether severity of impairment, pain, and seizure influenced these trajectories. We sought to identify potentially different trajectories of QoL from childhood to adulthood using a shape-based clustering method.Results: In total, 164 young adults with CP aged 22-27 years participated in the study. Psychological well-being linearly decreased by 0.78 points (scale 0-100) per year (95% confidence interval (CI) -0.99 to -0.56) from childhood to young adulthood, whereas QoL in the social relationships domain increased (beta coefficient 1.24, 95% CI 0.92-1.55). Severity of impairment was associated with reduced QoL in all life periods of the study (childhood, adolescence, and young adulthood): motor impairment with social relationships, and more nuancedly intellectual disability with psychological well-being and social relationships. At all periods, frequent pain significantly reduced psychological well-being, and seizures were associated with lower QoL in the social relationships domain. In both domains, we identified a group of individuals with CP who presented a reverse trajectory compared with the general QoL trajectory.Conclusion: Identification of QoL trajectories and their associated factors yields improved knowledge about the experience of individuals with CP until young adulthood. Further studies are needed to better understand the determinants that have the greatest influence on the different shapes of long-term trajectories of QoL.
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- Brink, Henning, et al.
(author)
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Analyzing Barriers to Digital Transformation in the German Engineering Industry : A Comparison of Digitalized and Non-Digitalized Enterprises
- 2022
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In: Proeccedings of the 55th Hawaii International Conference on System Sciences. - 9780998133157 ; , s. 4849-4858
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Conference paper (peer-reviewed)abstract
- The German engineering sector is one of the most prominent industries in Germany in terms of revenues, the number of employees, and reputation for the “Made in Germany” brand. In this industry, digital transformation (DT) has become a significant trend. DT is more than optimizing internal processes by digital means. It entails the offer of digital services and products and the enhancement of customer experience. Complex barriers need to be overcome to drive this transformation forward. Therefore, our study analysis the organizational barriers to DT within the German engineering industry. We follow a quantitative approach to gain insight on organizational barriers by a comparison of digitalized and less digitalized enterprises and their DTs. Our research demonstrates that digitalized enterprises perceive lower degrees of certain barriers in leadership, culture, employees, and skills, which are essential parts in a socio-technical view. However, there are still barriers that digitalized enterprises are struggling with.
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- Brink, Henning, et al.
(author)
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Barriers to Digital Transformation in SMEs : A Quantitative Study
- 2023
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In: Digital Economy. Emerging Technologies and Business Innovation. - : Springer. - 9783031427879 - 9783031427886 ; , s. 3-17
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Conference paper (peer-reviewed)abstract
- Digital transformation (DT) is a trending topic in nearly all industries. Enterprises digitalize processes, offer digital services and products, and enhance the customer experience. However, complex barriers hinder the ability of entrepreneurial-oriented small and medium-sized enterprises (SMEs) to advance in digital transformation. Using a questionnaire, we collected and analyzed data on the barriers to digital transformation in SMEs. The data revealed a heterogonous picture of SMEs regarding digital transformation and barriers. Based on 195 completed questionnaires, we demonstrated a significant negative influence of organizational and technical barriers and missing skills on digital transformation success. The identified predictors can explain 58% of the variance in the transformation process based on 195 respondents. We could not demonstrate a significant relationship to digital transformation success for the three additional barrier dimensions individual, lack of standards, and lack of laws. Nevertheless, respondents perceive the existence of a lack of standards and laws as well as individual barriers. Our results indicate that addressing organizational barriers is an excellent way to start a DT journey.
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- Brostromer, Erik, et al.
(author)
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An automated image-collection system for crystallization experiments using SBS standard microplates
- 2007
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In: Acta Crystallographica. Section D: Biological Crystallography. - 0907-4449. ; 63:Pt 2, s. 25-119
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Journal article (peer-reviewed)abstract
- As part of a structural genomics platform in a university laboratory, a low-cost in-house-developed automated imaging system for SBS microplate experiments has been designed and constructed. The imaging system can scan a microplate in 2-6 min for a 96-well plate depending on the plate layout and scanning options. A web-based crystallization database system has been developed, enabling users to follow their crystallization experiments from a web browser. As the system has been designed and built by students and crystallographers using commercially available parts, this report is aimed to serve as a do-it-yourself example for laboratory robotics.
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- Brostromer, Erik, et al.
(author)
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Solid-liquid interface method (SLIM) : a new crystallization method for proteins
- 2009
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In: Biochemical and Biophysical Research Communications. - : Elsevier BV. - 1090-2104 .- 0006-291X. ; 386:4, s. 8-634
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Journal article (peer-reviewed)abstract
- Despite impressive advances in theories, methods and technologies, crystallization still remains a serious bottleneck in structural determination of macromolecules. Here we present a novel solid-liquid interface method (SLIM) for protein crystallization, based on the pre-adding and drying of a crystallization reagent, and thereafter the dispensing of a protein solution to the dried media to initiate crystallization from the solid-liquid interface. Not only quick and easy to perform, the method also allows for a less concentrated protein solution for setting up crystallization trials.
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