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1.	Lavebratt, Catharina, et al. (author) CRY2 is associated with depression 2010 In: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 5:2 Journal article (peer-reviewed)abstract Background: Abnormalities in the circadian clockwork often characterize patients with major depressive and bipolar disorders. Circadian clock genes are targets of interest in these patients. CRY2 is a circadian gene that participates in regulation of the evening oscillator. This is of interest in mood disorders where a lack of switch from evening to morning oscillators has been postulated.Principal Findings: We observed a marked diurnal variation in human CRY2 mRNA levels from peripheral blood mononuclear cells and a significant up-regulation (P = 0.020) following one-night total sleep deprivation, a known antidepressant. In depressed bipolar patients, levels of CRY2 mRNA were decreased (P = 0.029) and a complete lack of increase was observed following sleep deprivation. To investigate a possible genetic contribution, we undertook SNP genotyping of the CRY2 gene in two independent population-based samples from Sweden (118 cases and 1011 controls) and Finland (86 cases and 1096 controls). The CRY2 gene was significantly associated with winter depression in both samples (haplotype analysis in Swedish and Finnish samples: OR = 1.8, P = 0.0059 and OR = 1.8, P = 0.00044, respectively).Conclusions: We propose that a CRY2 locus is associated with vulnerability for depression, and that mechanisms of action involve dysregulation of CRY2 expression.
2.	Sellgren, Carl M, et al. (author) Correction: GRK3 deficiency elicits brain immune activation and psychosis. 2021 In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 27:3 Journal article (peer-reviewed)

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Schalling, Martin (2); Vawter, Marquis P. (2); Landén, Mikael, 1966 (1); Sellgren, Carl M (1); Lavebratt, Catharina (1); Adolfsson, Rolf (1); show more...; Hökfelt, Tomas (1); Bhat, Maria (1); Erhardt, Sophie (1); Svensson, Camilla, I (1); Sjöholm, Louise K (1); Paunio, Tiina (1); Forsell, Yvonne (1); Cervenka, Simon (1); Orhan, Funda (1); Schwieler, Lilly (1); Engberg, Göran (1); Tufvesson-Alm, Maxim ... (1); Svedberg, Marie (1); Goiny, Michel (1); Codeluppi, Simone (1); Wu, Joseph C. (1); Partonen, Timo (1); Kelsoe, John R (1); Powell, Susan B (1); Choi, Doo-Sup (1); Kegel, Magdalena E. (1); Soronen, Pia (1); Bunney, William E. (1); Nilsson, Ida A. K. (1); Larsson, Markus K (1); Imbeault, Sophie (1); Oliveros, Alfredo (1); Gracias, Jessica (1); Zheng, Yiran (1); Faka, Anthi (1); Caldwell, Sorana (1); Kamenski, Mary E (1); Schulmann, Anton (1); show less...

University: Karolinska Institutet (2); University of Gothenburg (1); Umeå University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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