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1.	Yu, DM, et al. (author) Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD 2015 In: The American journal of psychiatry. - : American Psychiatric Association Publishing. - 1535-7228 .- 0002-953X. ; 172:1, s. 82-93 Journal article (peer-reviewed)
2.	Khramtsova, EA, et al. (author) Sex differences in the genetic architecture of obsessive-compulsive disorder 2019 In: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. - : Wiley. - 1552-485X. ; 180:6, s. 351-364 Journal article (peer-reviewed)
3.	McGrath, LM, et al. (author) Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study 2014 In: Journal of the American Academy of Child and Adolescent Psychiatry. - : Elsevier BV. - 1527-5418 .- 0890-8567. ; 53:8, s. 910-919 Journal article (peer-reviewed)
4.	Cappi, C, et al. (author) Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder 2012 In: Arquivos de neuro-psiquiatria. - : FapUNIFESP (SciELO). - 1678-4227 .- 0004-282X. ; 70:2, s. 87-90 Journal article (peer-reviewed)abstract Obsessive-compulsive disorder (OCD) is a prevalent psychiatric disorder of unknown etiology. However, there is some evidence that the immune system may play an important role in its pathogenesis. In the present study, two polymorphisms (rs1800795 and rs361525) in the promoter region of the cytokine tumor necrosis factor-alpha (TNFA) gene were genotyped in 183 OCD patients and in 249 healthy controls. The statistical tests were performed using the PLINK® software. We found that the A allele of the TNFA rs361525 polymorphism was significantly associated with OCD subjects, according to the allelic χ² association test (p=0.007). The presence of genetic markers, such as inflammatory cytokines genes linked to OCD, may represent additional evidence supporting the role of the immune system in its pathogenesis.

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Type of publication: journal article (4)

Type of content: peer-reviewed (4)

Author/Editor: Miguel, EC (4)Undo refine; Vallada, H (4); Brentani, H (4); Cappi, C (4); Sampaio, AS (4); Hounie, AG (4); show more...; Wang, Y. (3); Denys, D (3); Davis, LK (3); Arnold, PD (3); Hanna, GL (3); Lochner, C (3); Walitza, S (3); Wagner, M. (3); Derks, EM (3); Ruhrmann, S (3); Nurmi, E. (3); Knowles, JA (3); Falkai, P. (3); Leboyer, M. (3); Delorme, R. (3); Maier, W (3); Posthuma, D (3); Macciardi, F (3); Piacentini, J (3); Nicolini, H (3); Nestadt, G. (3); Stein, DJ (2); Evans, P. (2); Cath, DC (2); Pittenger, C (2); Pato, CN (2); Pato, MT (2); Grabe, HJ (2); Cox, NJ (2); Neale, BM (2); Cullen, B (2); Heutink, P (2); King, RA (2); Smit, JH (2); Oostra, BA (2); Cusi, D (2); Marconi, M. (2); Grünblatt, E (2); McGrath, LM (2); Stewart, SE (2); Sandor, P (2); Kennedy, JL (2); Jankovic, J (2); Gallagher, P. (2); show less...

University: Karolinska Institutet (4)

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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