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Träfflista för sökning "WFRF:(Alfredsson L) "

Search: WFRF:(Alfredsson L)

  • Result 61-70 of 674
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  • Forstner, A. J., et al. (author)
  • Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression
  • 2021
  • In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 26
  • Journal article (peer-reviewed)abstract
    • Panic disorder (PD) has a lifetime prevalence of 2–4% and heritability estimates of 40%. The contributory genetic variants remain largely unknown, with few and inconsistent loci having been reported. The present report describes the largest genome-wide association study (GWAS) of PD to date comprising genome-wide genotype data of 2248 clinically well-characterized PD patients and 7992 ethnically matched controls. The samples originated from four European countries (Denmark, Estonia, Germany, and Sweden). Standard GWAS quality control procedures were conducted on each individual dataset, and imputation was performed using the 1000 Genomes Project reference panel. A meta-analysis was then performed using the Ricopili pipeline. No genome-wide significant locus was identified. Leave-one-out analyses generated highly significant polygenic risk scores (PRS) (explained variance of up to 2.6%). Linkage disequilibrium (LD) score regression analysis of the GWAS data showed that the estimated heritability for PD was 28.0–34.2%. After correction for multiple testing, a significant genetic correlation was found between PD and major depressive disorder, depressive symptoms, and neuroticism. A total of 255 single-nucleotide polymorphisms (SNPs) with p < 1 × 10−4 were followed up in an independent sample of 2408 PD patients and 228,470 controls from Denmark, Iceland and the Netherlands. In the combined analysis, SNP rs144783209 showed the strongest association with PD (pcomb = 3.10 × 10−7). Sign tests revealed a significant enrichment of SNPs with a discovery p-value of <0.0001 in the combined follow up cohort (p = 0.048). The present integrative analysis represents a major step towards the elucidation of the genetic susceptibility to PD. © 2019, The Author(s), under exclusive licence to Springer Nature Limited.
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64.
  • Fransson, Eleonor, 1971-, et al. (author)
  • Job strain as a risk factor for leisure-time physical inactivity : an individual-participant meta-analysis of up to 170,000 men and women
  • 2012
  • In: American Journal of Epidemiology. - Cary : Oxford University Press. - 0002-9262 .- 1476-6256. ; 176:12, s. 1078-1089
  • Research review (peer-reviewed)abstract
    • Unfavorable work characteristics, such as low job control and too high or too low job demands, have been suggested to increase the likelihood of physical inactivity during leisure time, but this has not been verified in large-scale studies. The authors combined individual-level data from 14 European cohort studies (baseline years from 19851988 to 20062008) to examine the association between unfavorable work characteristics and leisure-time physical inactivity in a total of 170,162 employees (50 women; mean age, 43.5 years). Of these employees, 56,735 were reexamined after 29 years. In cross-sectional analyses, the odds for physical inactivity were 26 higher (odds ratio 1.26, 95 confidence interval: 1.15, 1.38) for employees with high-strain jobs (low control/high demands) and 21 higher (odds ratio 1.21, 95 confidence interval: 1.11, 1.31) for those with passive jobs (low control/low demands) compared with employees in low-strain jobs (high control/low demands). In prospective analyses restricted to physically active participants, the odds of becoming physically inactive during follow-up were 21 and 20 higher for those with high-strain (odds ratio 1.21, 95 confidence interval: 1.11, 1.32) and passive (odds ratio 1.20, 95 confidence interval: 1.11, 1.30) jobs at baseline. These data suggest that unfavorable work characteristics may have a spillover effect on leisure-time physical activity.
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  • Result 61-70 of 674
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journal article (437)
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Type of content
peer-reviewed (395)
other academic/artistic (278)
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Author/Editor
Alfredsson, L (588)
KLARESKOG, L (249)
Olsson, T (170)
Padyukov, L (119)
Kockum, I. (116)
Hillert, J (103)
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Bengtsson, C (72)
Hedstrom, AK (68)
Saevarsdottir, S (63)
Askling, J (51)
Kallberg, H (48)
Jiang, X. (43)
Alfredsson, Lars (39)
Ding, B. (32)
Theorell, Töres (29)
Westerlund, Hugo (28)
Nordin, Maria (27)
Westerlind, H (27)
Karlson, EW (26)
Hammar, N (24)
Piehl, F (24)
Vahtera, Jussi (23)
Plenge, RM (23)
Knutsson, Anders (23)
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Singh-Manoux, Archan ... (23)
Virtanen, Marianna (22)
Pentti, Jaana (22)
Stridh, P (22)
Lundberg, K. (22)
Ronnelid, J (21)
Burr, Hermann (21)
Borritz, Marianne (21)
Barcellos, LF (20)
Madsen, Ida E. H. (20)
Nielsen, Martin L. (20)
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Bjorner, Jakob B. (18)
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Raychaudhuri, S (17)
Hansson, M (17)
Manouchehrinia, A (17)
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