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Search: WFRF:(Landen M)

  • Result 261-270 of 375
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261.
  • Kyaga, S, et al. (author)
  • Creativity and mental disorder Reply
  • 2012
  • In: BRITISH JOURNAL OF PSYCHIATRY. - : Royal College of Psychiatrists. - 0007-1250 .- 1472-1465. ; 200:4, s. 348-348
  • Journal article (other academic/artistic)
  •  
262.
  • Landen, Jaren W., et al. (author)
  • Ponezumab in mild-to-moderate Alzheimer's disease : Randomized phase II PET-PIB study
  • 2017
  • In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. - : Wiley. - 2352-8737. ; 3:3, s. 393-401
  • Journal article (peer-reviewed)abstract
    • Introduction The safety, pharmacokinetics, and effect on peripheral and central amyloid β (Aβ) of multiple doses of ponezumab, an anti-Aβ monoclonal antibody, were characterized in subjects with mild-to-moderate Alzheimer's disease treated for 1 year. Methods Subjects were aged ≥50 years with Mini–Mental State Examination scores 16 to 26. Cohort Q was randomized to ponezumab 10 mg/kg (n = 12) or placebo (n = 6) quarterly. Cohort M was randomized to a loading dose of ponezumab 10 mg/kg or placebo, followed by monthly ponezumab 7.5 mg/kg (n = 12) or placebo (n = 6), respectively. Results Ponezumab was generally well tolerated. Plasma concentrations increased dose dependently, but cerebrospinal fluid (CSF) penetration was low. Plasma Aβ increased dose dependently with ponezumab, but CSF biomarkers, brain amyloid burden, cognition, and function were not affected. Conclusions Both ponezumab dosing schedules were generally safe and well tolerated but did not alter CSF biomarkers, brain amyloid burden, or clinical outcomes.
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  • Result 261-270 of 375
Type of publication
journal article (254)
conference paper (115)
research review (5)
other publication (1)
Type of content
peer-reviewed (246)
other academic/artistic (129)
Author/Editor
Landén, Mikael, 1966 (167)
Landen, M (161)
Lichtenstein, P. (50)
Landén, NX (38)
Cichon, S (34)
Reif, A. (33)
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Rietschel, M (30)
Ripke, S (28)
Bellivier, F. (28)
Etain, B. (28)
Leboyer, M. (28)
Bauer, M (27)
Eriksson, E (27)
Vieta, E (26)
Schalling, M (26)
Herms, S. (26)
Alda, M. (26)
Stahle, M (25)
Jamain, S. (25)
Breen, G (23)
Mattheisen, M (22)
Muller-Myhsok, B (22)
Backlund, L (22)
Degenhardt, F (22)
Craddock, N (21)
Hauser, J. (21)
Martin, NG (20)
Grigoroiu-Serbanescu ... (20)
Westberg, L (20)
Song, J. (19)
Sellgren, C (19)
Sonkoly, E (19)
Dannlowski, U (19)
Palsson, E (19)
Li, D. (18)
Alda, Martin (18)
Sklar, P (18)
Frisen, L. (18)
Pfennig, A. (18)
Andreassen, O. A. (18)
McGuffin, P (18)
Mitchell, Philip B (17)
Ekman, CJ (17)
Hoffmann, P (17)
Jones, I. (17)
Baune, B. T. (17)
Kittel-Schneider, S. (17)
O'Donovan, C. (17)
Hultman, C. M. (17)
Pivarcsi, A (17)
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University
Karolinska Institutet (353)
University of Gothenburg (172)
Umeå University (24)
Uppsala University (22)
Örebro University (17)
Linköping University (10)
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Lund University (10)
Chalmers University of Technology (6)
Royal Institute of Technology (1)
Stockholm University (1)
RISE (1)
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Language
English (375)
Research subject (UKÄ/SCB)
Medical and Health Sciences (185)
Natural sciences (7)
Engineering and Technology (6)
Social Sciences (3)

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