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Träfflista för sökning "WFRF:(Parker B.) "

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691.	Meinow, B, et al. (author) Who receives more hours of help?: Predictors of the amount of home-help among elderly living alone in Sweden 2003 In: GERONTOLOGIST. - 0016-9013. ; 43, s. 461-461 Conference paper (other academic/artistic)
692.	Morgan, Alexandra R, et al. (author) Feasibility assessment of using oxygen-enhanced magnetic resonance imaging for evaluating the effect of pharmacological treatment in COPD. 2014 In: European Journal of Radiology. - : Elsevier BV. - 1872-7727 .- 0720-048X. ; 83:11, s. 2093-2101 Journal article (peer-reviewed)abstract Oxygen-enhanced MRI (OE-MRI) biomarkers have potential value in assessment of COPD, but need further evaluation before treatment-induced changes can be interpreted. The objective was to evaluate how OE-MRI parameters of regional ventilation and oxygen uptake respond to standard pharmacological interventions in COPD, and how the response compares to that of gold standard pulmonary function tests.
693.	Mühlenbock, Per, et al. (author) Redox changes in the chloroplast initiate ethylene dependent signaling controlled by LESION SIMULATING DISEASE1 in Arabidopsis Journal article (peer-reviewed)
694.	Nilsson, S, et al. (author) Alpha-emitting Radium-223: two years follow up from a randomized phase II study in patients with bone metastases from hormone refractory prostate cancer 2009 In: EJC SUPPLEMENTS. - 1359-6349. ; 7:2, s. 412-412 Conference paper (other academic/artistic)
695.	Nilsson, S., et al. (author) Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo-controlled phase II study 2007 In: Lancet Oncol. - 1470-2045 .- 1474-5488. ; 8:7, s. 587-594 Journal article (peer-reviewed)abstract BACKGROUND: The alpha-emitter radium-223 ((223)Ra) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone-refractory prostate cancer. We aimed to study mature outcomes from a randomised, multicentre, phase II study of (223)Ra. METHODS: Patients with hormone-refractory prostate cancer and bone pain needing external-beam radiotherapy were assigned to four intravenous injections of (223)Ra (50 kBq/kg, 33 patients) or placebo (31 patients), given every 4 weeks. Primary endpoints were change in bone-alkaline phosphatase (ALP) concentration and time to skeletal-related events (SREs). Secondary endpoints included toxic effects, time to prostate-specific-antigen (PSA) progression, and overall survival. All tests were done at a 5% significance level, based on intention to treat. FINDINGS: Median relative change in bone-ALP during treatment was -65.6% (95% CI -69.5 to -57.7) and 9.3% (3.8-60.9) in the (223)Ra group and placebo groups, respectively (p<0.0001, Wilcoxon ranked-sums test). Hazard ratio for time to first SRE, adjusted for baseline covariates, was 1.75 (0.96-3.19, p=0.065, Cox regression). Haematological toxic effects did not differ significantly between two groups. No patient discontinued (223)Ra because of treatment toxicity. Median time to PSA progression was 26 weeks (16-39) versus 8 weeks (4-12; p=0.048) for (223)Ra versus placebo, respectively. Median overall survival was 65.3 weeks (48.7-infinity) for (223)Ra and 46.4 weeks (32.1-77.4) for placebo (p=0.066, log rank). The hazard ratio for overall survival, adjusted for baseline covariates was 2.12 (1.13-3.98, p=0.020, Cox regression). INTERPRETATION: (223)Ra was well tolerated with minimum myelotoxicity, and had a significant effect on bone-ALP concentrations. Larger clinical trials are warranted to study (223)Ra on the prevention of SREs and on overall survival in patients with hormone-refractory prostate cancer. Bone-targeting properties of (223)Ra could also potentially be used for treating skeletal metastasis from other primary cancers.
696.	Nilsson, S, et al. (author) Placebo-controlled, randomized, phase II study of radium-223 in metastatic hormone refractory prostate cancer (HRPC) 2007 In: EJC SUPPLEMENTS. - 1359-6349. ; 5:4, s. 295-295 Conference paper (other academic/artistic)
697.	Nilsson, S, et al. (author) Radium-223 in the treatment of metastatic hormone refractory prostate cancer (HRPC): Results from a randomized, placebo-controlled, phase II study 2007 In: JOURNAL OF CLINICAL ONCOLOGY. - 0732-183X. ; 25:18 Conference paper (other academic/artistic)
698.	Novakovic, T, et al. (author) The value of innovation in decision-making in health care in Central Eastern Europe - The Sixth International Conference, 2 June 2017, Belgrade, Serbia 2017 In: Expert review of pharmacoeconomics & outcomes research. - : Informa UK Limited. - 1744-8379 .- 1473-7167. ; 17:6, s. 519-521 Journal article (other academic/artistic)
699.	Olofsson, J., et al. (author) Picosecond Kerr-gated time-resolved resonance Raman spectroscopy of the Ru(phen)(2)dppz (2+) interaction with DNA 2002 In: Journal of Inorganic Biochemistry. - 0162-0134 .- 1873-3344. ; 91:1, s. 286-297 Journal article (peer-reviewed)abstract To investigate the basis of the 'light-switch' effect, the solvent dependence of the Kerr-gated picosecond-time resolved resonance Raman (TR3) spectra of [Ru(bpy),dppz](2+), [Ru(phen)(2)dppz](2+), and the modified complex [Ru(phen)(2)cpdppzOMe](2+) and a dimer [mu-C4(cpdppz)(2)-(phen)(4)Ru-2](4+) were studied. The investigation focussed on comparing the behaviour of [Ru(phen)(2)dppz](2+) in acetonitrile, ethanol, H2O, D2O, and DNA. The data are consistent with a model wherein excitation induces metal-to-ligand charge transfer (MLCT) to any of the ligands (termed the 'precursor' state) which, by interligand electron transfer (ILET), produces an excited state localised on the dppz ligand, MLCT1. In water this state relaxes with a characteristic time of similar to6 ps to a non-emissive state (MLCT2). The TR3 spectra in water, acetonitrile and DNA are all distinctly different. However. the early (4 ps) water spectrum resembles the spectrum in DNA. This interesting observation suggests that the DNA-bound excited state of the complex can be thought of as a model for the initial, poorly solvated state in water.
700.	O'Sullivan, J. M., et al. (author) EXTERNAL-BEAM RADIATION THERAPY (EBRT) USE AND SAFETY WITH RADIUM-223 DICHLORIDE (RA) IN PATIENTS (PTS) WITH CASTRATION-RESISTANT PROSTATE CANCER (CRPC) AND SYMPTOMATIC BONE METASTASES (METS) FROM THE ALSYMPCATRIAL 2014 In: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 25:suppl 4, s. 768P- Journal article (other academic/artistic)

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Type of content: peer-reviewed (698); other academic/artistic (50); pop. science, debate, etc. (1)

Author/Editor: Clark, A. (478); Fox, H. (477); Moore, R. W. (477); Kolanoski, H. (476); Robson, A. (476); D'Onofrio, M. (475); show more...; Hou, S. (473); Price, D. (473); Li, H. (472); Mehta, A. (472); Nakano, I. (472); Bocci, A. (471); Burdin, S. (471); Evans, H. (471); Giokaris, N. (471); Gorelov, I. (471); Hubacek, Z. (471); Kehoe, R. (471); Kim, S. H. (471); Kupco, A. (471); Limosani, A. (471); Lipeles, E. (471); Loginov, A. (471); Lokajicek, M. (471); Meyer, J. (471); Pleier, M. -A. (471); Qian, J. (471); Quadt, A. (471); Sawyer, L. (471); Abbott, B. (470); Borissov, G. (470); Boudreau, J. (470); Brandt, A. (470); Cerri, A. (470); Cerrito, L. (470); Errede, S. (470); Hohlfeld, M. (470); Khanov, A. (470); Kroll, J. (470); Neal, H. A. (470); Oh, S. H. (470); Parker, M. A. (470); Annovi, A. (469); Brock, R. (469); Campanelli, M. (469); Cooke, M. (469); Hughes, G. (469); Lee, S. C. (469); Rizatdinova, F. (469); Schwienhorst, R. (469); show less...

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