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Träfflista för sökning "WFRF:(van Vliet Ostaptchouk Jana V.) "

Search: WFRF:(van Vliet Ostaptchouk Jana V.)

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11.
  • Marouli, Eirini, et al. (author)
  • Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease
  • 2019
  • In: Communications Biology. - : Springer Nature. - 2399-3642. ; 2
  • Journal article (peer-reviewed)abstract
    • There is evidence that lower height is associated with a higher risk of coronary artery disease (CAD) and increased risk of type 2 diabetes (T2D). It is not clear though whether these associations are causal, direct or mediated by other factors. Here we show that one standard deviation higher genetically determined height (similar to 6.5 cm) is causally associated with a 16% decrease in CAD risk (OR = 0.84, 95% CI 0.80-0.87). This causal association remains after performing sensitivity analyses relaxing pleiotropy assumptions. The causal effect of height on CAD risk is reduced by 1-3% after adjustment for potential mediators (lipids, blood pressure, glycaemic traits, body mass index, socio-economic status). In contrast, our data suggest that lung function (measured by forced expiratory volume [FEV1] and forced vital capacity [FVC]) is a mediator of the effect of height on CAD. We observe no direct causal effect of height on the risk of T2D.
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  • Result 11-11 of 11
Type of publication
journal article (11)
Type of content
peer-reviewed (11)
Author/Editor
van Vliet-Ostaptchou ... (11)
Wareham, Nicholas J. (9)
Boehnke, Michael (9)
Loos, Ruth J F (9)
Groop, Leif (8)
Campbell, Harry (8)
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Rudan, Igor (8)
Kuusisto, Johanna (8)
Laakso, Markku (8)
McCarthy, Mark I (8)
van Duijn, Cornelia ... (8)
Mohlke, Karen L (8)
Tuomilehto, Jaakko (8)
Wilson, James F. (8)
Hofman, Albert (8)
Deloukas, Panos (7)
Langenberg, Claudia (7)
Hamsten, Anders (7)
Qi, Lu (7)
Thorleifsson, Gudmar (7)
Thorsteinsdottir, Un ... (7)
Stefansson, Kari (7)
Abecasis, Goncalo R. (7)
Mangino, Massimo (7)
Gieger, Christian (7)
Froguel, Philippe (7)
Pramstaller, Peter P ... (7)
Uitterlinden, André ... (7)
Hayward, Caroline (7)
Illig, Thomas (7)
Lyssenko, Valeriya (6)
Ohlsson, Claes, 1965 (6)
Ridker, Paul M. (6)
Chasman, Daniel I. (6)
Amin, Najaf (6)
Rose, Lynda M (6)
Willemsen, Gonneke (6)
Oostra, Ben A. (6)
Peters, Annette (6)
Jarvelin, Marjo-Riit ... (6)
Barroso, Ines (6)
Luan, Jian'an (6)
Palmer, Colin N. A. (6)
Hicks, Andrew A. (6)
Zillikens, M. Carola (6)
Rivadeneira, Fernand ... (6)
Thorand, Barbara (6)
Hirschhorn, Joel N. (6)
McKnight, Barbara (6)
Cupples, L. Adrienne (6)
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University
Lund University (9)
Uppsala University (8)
Karolinska Institutet (7)
University of Gothenburg (6)
Umeå University (5)
Högskolan Dalarna (2)
Language
English (11)
Research subject (UKÄ/SCB)
Medical and Health Sciences (10)
Natural sciences (1)

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