| 1. |
- Berg, Thomas, 1975-
(författare)
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Medical Treatment and Grading of Bell's Palsy
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The main aim of this thesis was to evaluate the effect of prednisolone and valaciclovir in a large number of Bell's palsy patients. The incidence and intensity of pain around the ear, in the face or in the neck during the first two months of palsy, and its prognostic value, was also assessed. We also investigated how study design and choice of analysis method affect the rate of facial recovery. Furthermore, the agreement between the Sunnybrook, House-Brackmann and Yanagihara facial grading systems was evaluated. From May 2001 to September 2007, a prospective, randomised, double-blind, placebo-controlled, multicentre trial with 12-month follow-up was performed in patients with Bell's palsy. Of 839 randomised patients, 829 were included in the intention-to-treat analysis; 206 received placebo plus placebo, 210 prednisolone plus placebo, 207 valaciclovir plus placebo, and 206 prednisolone plus valaciclovir. Time to recovery was significantly shorter in the 416 patients who received prednisolone compared with the 413 who did not (p<0.0001). At 12 months, 300 of 416 patients (72%) in the prednisolone group had recovered compared with 237 of 413 patients (57%) in the no prednisolone group (p<0.0001). Valaciclovir was not found to affect time to facial recovery or outcome at 12 months. Prednisolone and/or valaciclovir did not affect the incidence or intensity of pain. Presence of pain at day 11 to 17 indicated a worse prognosis for facial recovery at 12 months. We also found that recovery rates in a Bell's palsy trial are substantially affected by the choice of analysis method and definition of facial recovery. We used weighted Kappa statistics in 100 examinations of patients with facial palsy to assess the agreement between the Sunnybrook, House-Brackmann and Yanagihara scales. The highest agreement was found between the regional Sunnybrook and Yanagihara scales. An evaluative difference between the Sunnybrook and House-Brackmann systems was observed.
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| 2. |
- Åhman, Mats, et al.
(författare)
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Nasal symptoms and pathophysiology in farmers
- 2001
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Ingår i: International Archives of Occupational and Environmental Health. - 0340-0131 .- 1432-1246. ; 74:4, s. 279-84
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Increased morbidity and mortality in lower airway diseases have been reported among farmers. The aim of this study was to assess upper airway problems in farmers. SUBJECTS AND METHODS: Twenty-five dairy farmers, 20 pig farmers, 21 grain farmers and 19 control subjects were studied, by use of questionnaire, skin-prick test, dynamic spirometry, nasal inspection, acoustic rhinometry (before and after a decongestant) as well as by determinations of the olfactory threshold and nasal lavage (NAL) concentrations of eosinophil cationic protein (ECP), myeloperoxidase (MPO) and albumin. RESULTS: Compared with the control group, farmers had more complaints of work-related symptoms from the lower airways, and symptoms of smell impairment, and more often had nasal polyps and hyperaemia of the nasal mucosa. They also had higher levels of MPO in NAL (especially dairy farmers and pig farmers), and a tendency to more swollen nasal mucosa and lower olfactory threshold (especially grain farmers). CONCLUSIONS: The farmers had more pathological findings in their nasal mucosa, possibly indicating effects of allergens and irritants in their work environment. More studies are needed to evaluate work environment factors causing these pathological findings in farmers.
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| 3. |
- Ahlgren, Karin, et al.
(författare)
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De stora restaureringarna : Från Uppsala domkyrka till Skokloster
- 2004
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Rapport (populärvet., debatt m.m.)abstract
- De stora restaureringarna har varit årets tema. Genom att dokumentera och analysera teori och praktik i några av 1800- och 1900-talets största restaureringar - från genomgripande stilrestaureringar till ett mer återhållsamt och tekniskt skonsamt synsätt. Därmed får vi också ett bättre underlag även för dagens ställningstagande.Föremål för våra studier är Uppsala domkyrka, Gripsholms slott, Vreta klosterkyrka, Gustav 11I:s paviljong i Haga, Kungapalatset i Vadstena och Skoklosters slott. Vi hoppas att denna utställning skall bidra till en kritisk hållning och en ökad kunskap om restaureringskonsten, som kvalificerad yrkesuppgift, tidsspegel för historiesyn och som gestaltningsideal.
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| 4. |
- Aksoy, Samet, et al.
(författare)
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Forest Biophysical Parameter Estimation via Machine Learning and Neural Network Approaches
- 2023
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Ingår i: IGARSS 2023 - 2023 IEEE International Geoscience and Remote Sensing Symposium. - : IEEE. - 9798350320107 - 9798350320091 - 9798350331745 ; , s. 2661-2664
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Konferensbidrag (refereegranskat)abstract
- This paper presents the first results of the ongoing development of new forest mapping methods for the Swedish national forest mapping case using Airborne Laser Scanning (ALS) data, utilizing the recent findings in machine learning (ML) and Artificial Intelligence (AI) techniques. We used Random Forest (RF) and eXtreme Gradient Boosting (XGBoost) as ML models. In addition, Neural networks (NN) based approaches were utilized in this study. ALS derived features were used to estimate the stem volume (V), above-ground biomass (AGB), basal area (B), tree height (H), stem diameter (D), and forest stand age (A). XGBoost ML algorithm outperformed RF 1 % to 3 % in the R² metric. NN model performed similar to ML model, however it is superior in the estimation of V, AGB, and B parameters.
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| 5. |
- Asplund, Monika Stenkvist, et al.
(författare)
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Chemotherapy in severe nasal polyposis - a possible beneficial effect? : A report of three cases
- 2010
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Ingår i: Rhinology. - 0300-0729 .- 1996-8604. ; 48:3, s. 374-376
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Tidskriftsartikel (refereegranskat)abstract
- Background: Nasal polyposis is an inflammatory process of the nasal mucosa. Treatment has changed from surgery to an anti-inflammatory approach, but neither of these treatments addresses the underlying cause. Topical steroids and occasional use of systemic steroids in patients with nasal polyposis can frequently control the polypoid disease. In a few cases, when the disease is more aggressive, the repeated application of systemic steroids together with sinus surgery is required. Material and Methods: We present our experience with one case of rheumatoid arthritis and two cases with malignant diseases, all of which were treated with chemotherapy and were also accompanied by severe nasal polyposis. All of our patients had eosinophilic polypoid disease. Various chemotherapeutic treatment schemes were utilized. Results: During chemotherapy all three patients were markedly improved symptomatically including olfaction along with a significant reduction in their nasal polyposis. Duration of remission lasted for a few months in two cases and for three years, in a third case. Conclusion: This is the first report describing the successful treatment of severe nasal polyposis with chemotherapy. Based on this experience, we suggest a phase II trial with chemotherapy, preferably "low dose" methotrexate, in patients with severe nasal polyposis.
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| 6. |
- Austeng, Dordi, et al.
(författare)
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Incidence of and risk factors for neonatal morbidity after active perinatal care : extremely preterm infants study in Sweden (EXPRESS)
- 2010
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Ingår i: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 99:7, s. 978-992
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Tidskriftsartikel (refereegranskat)abstract
- Aims: The aim of this study was to determine the incidence of neonatal morbidity in extremely preterm infants and to identify associated risk factors. Methods: Population based study of infants born before 27 gestational weeks and admitted for neonatal intensive care in Sweden during 2004-2007. Results: Of 638 admitted infants, 141 died. Among these, life support was withdrawn in 55 infants because of anticipation of poor long-term outcome. Of 497 surviving infants, 10% developed severe intraventricular haemorrhage (IVH), 5.7% cystic periventricular leucomalacia (cPVL), 41% septicaemia and 5.8% necrotizing enterocolitis (NEC); 61% had patent ductus arteriosus (PDA) and 34% developed retinopathy of prematurity (ROP) stage >= 3. Eighty-five per cent needed mechanical ventilation and 25% developed severe bronchopulmonary dysplasia (BPD). Forty-seven per cent survived to one year of age without any severe IVH, cPVL, severe ROP, severe BPD or NEC. Tocolysis increased and prolonged mechanical ventilation decreased the chances of survival without these morbidities. Maternal smoking and higher gestational duration were associated with lower risk of severe ROP, whereas PDA and poor growth increased this risk. Conclusion: Half of the infants surviving extremely preterm birth suffered from severe neonatal morbidities. Studies on how to reduce these morbidities and on the long-term health of survivors are warranted.
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| 7. |
- Barck, Charlotte, et al.
(författare)
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Does nitrogen dioxide affect inflammatory markers after nasal allergen challenge?
- 2005
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Ingår i: American Journal of Rhinology. - : SAGE Publications. - 1050-6586 .- 1539-6290. ; 19:6, s. 560-566
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Exposure to high ambient levels of nitrogen dioxide (NO2) enhances the bronchial inflammatory reaction to allergen in humans. We tested whether this NO2 effect occurs also in the upper airways. METHODS: Sixteen allergic subjects with rhinitis and mild asthma were exposed at rest to either purified air or 500 microg/m3 NO2 for 30 minutes, followed 4 hours later by a nasal allergen challenge. Nasal lavage was performed before air/NO2 exposure, before allergen challenge, and 1, 4 and 18 hours after allergen challenge. Symptoms were recorded. RESULTS: The percentage of eosinophils and neutrophils, eosinophil cationic protein, and myeloperoxidase were similar after exposure to air + allergen and to NO2 + allergen. We noticed a tendency to increased sneezing the day after exposure to NO2 + allergen. CONCLUSION: The priming effect of an ambient brief NO2 exposure on subsequent allergic response was not noticeable in activation of inflammatory cells and mediators in the upper airways.
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| 8. |
- Behar, Etienne, et al.
(författare)
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Mass-loading of the solar wind at 67P/Churyumov-Gerasimenko : Observations and modelling
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 596
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Tidskriftsartikel (refereegranskat)abstract
- Context. The first long-term in-situ observation of the plasma environment in the vicinity of a comet, as provided by the European Rosetta spacecraft.Aims. Here we offer characterisation of the solar wind flow near 67P/Churyumov-Gerasimenko (67P) and its long term evolution during low nucleus activity. We also aim to quantify and interpret the deflection and deceleration of the flow expected from ionization of neutral cometary particles within the undisturbed solar wind.Methods. We have analysed in situ ion and magnetic field data and combined this with hybrid modeling of the interaction between the solar wind and the comet atmosphere.Results. The solar wind deflection is increasing with decreasing heliocentric distances, and exhibits very little deceleration. This is seen both in observations and in modeled solar wind protons. According to our model, energy and momentum are transferred from the solar wind to the coma in a single region, centered on the nucleus, with a size in the order of 1000 km. This interaction affects, over larger scales, the downstream modeled solar wind flow. The energy gained by the cometary ions is a small fraction of the energy available in the solar wind.Conclusions. The deflection of the solar wind is the strongest and clearest signature of the mass-loading for a small, low-activity comet, whereas there is little deceleration of the solar wind.
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| 9. |
- Behar, Etienne, et al.
(författare)
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Menura : A code for simulating the interaction between a turbulent solar wind and solar system bodies
- 2022
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Ingår i: Annales Geophysicae. - : Copernicus GmbH. - 0992-7689 .- 1432-0576. ; 40:3, s. 281-297
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Tidskriftsartikel (refereegranskat)abstract
- Despite the close relationship between planetary science and plasma physics, few advanced numerical tools allow bridging the two topics. The code Menura proposes a breakthrough towards the self-consistent modelling of these overlapping fields, in a novel two-step approach allowing for the global simulation of the interaction between a fully turbulent solar wind and various bodies of the solar system. This article introduces the new code and its two-step global algorithm, illustrated by a first example: the interaction between a turbulent solar wind and a comet.
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| 10. |
- Behar, Etienne, et al.
(författare)
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Solar wind dynamics around a comet : A 2D semi-analytical kinetic model
- 2018
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 620
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Tidskriftsartikel (refereegranskat)abstract
- Aims.We aim at analytically modelling the solar wind proton trajectories during their interaction with a partially ionised cometaryatmosphere, not in terms of bulk properties of the flow but in terms of single particle dynamics.Methods.We first derive a generalised gyromotion, in which the electric field is reduced to its motional component. Steady-stateis assumed, and simplified models of the cometary density and of the electron fluid are used to express the force experienced byindividual solar wind protons during the interaction.Results.A three-dimensional (3D) analytical expression of the gyration of two interacting plasma beams is obtained. Applying it to acomet case, the force on protons is always perpendicular to their velocity and has an amplitude proportional to 1/r2. The solar winddeflection is obtained at any point in space. The resulting picture presents a caustic of intersecting trajectories, and a circular regionis found that is completely free of particles. The particles do not lose any kinetic energy and this absence of deceleration, togetherwith the solar wind deflection pattern and the presence of a solar wind ion cavity, is in good agreement with the general results of theRosettamission.Conclusions.The qualitative match between the model and thein situdata highlights how dominant the motional electric field isthroughout most of the interaction region for the solar wind proton dynamics. The model provides a simple general kinetic descriptionof how momentum is transferred between these two collisionless plasmas. It also shows the potential of this semi-analytical modelfor a systematic quantitative comparison to the data.
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