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1.	Skibola, Christine F, et al. (author) Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region. 2014 In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 95:4, s. 462-471 Journal article (peer-reviewed)abstract Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10(-67) to 2.67 × 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [ORper-allele] = 1.44; p = 4.59 × 10(-16)) and rs3130437 in HLA class I (ORper-allele = 1.23; p = 8.23 × 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.

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Type of publication: journal article (1)

Type of content: peer-reviewed (1)

Author/Editor: Glimelius, Bengt (1); Smedby, Karin E. (1); Adami, Hans Olov (1); Melbye, Mads (1); Weiderpass, Elisabet ... (1); Berndt, Sonja I (1); show more...; Chanock, Stephen J (1); Albanes, Demetrius (1); Travis, Ruth C (1); Giles, Graham G (1); Severi, Gianluca (1); Ohlsson, Bodil (1); Vineis, Paolo (1); North, Kari E. (1); Chamosa, Saioa (1); Boffetta, Paolo (1); Offit, Kenneth (1); Spinelli, John J. (1); Teras, Lauren R. (1); Kraft, Peter (1); Diver, W Ryan (1); Giovannucci, Edward (1); Virtamo, Jarmo (1); Yeager, Meredith (1); Hjalgrim, Henrik (1); Brennan, Paul (1); Foo, Jia Nee (1); Vermeulen, Roel C. H ... (1); Bracci, Paige M (1); Holly, Elizabeth A (1); Hutchinson, Amy (1); Zeleniuch-Jacquotte, ... (1); Hartge, Patricia (1); Foretova, Lenka (1); Vijai, Joseph (1); Becker, Nikolaus (1); Rothman, Nathaniel (1); Lan, Qing (1); de Bakker, Paul I. W ... (1); McKay, James (1); Conde, Lucia (1); Liu, Jianjun (1); Skibola, Christine F ... (1); Armstrong, Bruce K. (1); Cerhan, James R. (1); Wang, Sophia S. (1); Benavente, Yolanda (1); Bertrand, Kimberly A ... (1); Birmann, Brenda M. (1); Brooks-Wilson, Angel ... (1); show less...

University: Uppsala University (1); Lund University (1); Karolinska Institutet (1)

Language: English (1)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2014 (1)

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