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Träfflista för sökning "WFRF:(Lindgren Cecilia) "

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1.	Oelker, Melanie, et al. (author) Discovery of three new binding sites and modes of ring-fused 2-pyridones to PrfA : How can they contribute to drug design? Other publication (other academic/artistic)
2.	Dahl, Thomas, et al. (author) Conference Review : Chilhood and the State - the State of Childhood. The Society for the History of Children and Youth (SHCY) Bi-Annual Conference 26-29 June 2003 In: H-Education. ; October Journal article (other academic/artistic)
3.	Knowledge formation in and through music : Festschrift in honor of Cecilia K. Hultberg 2015 2015 Editorial collection (other academic/artistic)
4.	Knutsson, Sofie, et al. (author) Binding Mode of Reversible Inhibitors in Mosquito Acetylcholinesterase 1 Governs their Selective and Resistance-Breaking Potency Other publication (other academic/artistic)
5.	Knutsson, Sofie, et al. (author) Noncovalent Inhibitors of Mosquito Acetylcholinesterase 1 with Resistance-Breaking Potency 2018 In: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 61:23, s. 10545-10557 Journal article (peer-reviewed)abstract Resistance development in insects significantly threatens the important benefits obtained by insecticide usage in vector control of disease-transmitting insects. Discovery of new chemical entities with insecticidal activity is highly desired in order to develop new insecticide candidates. Here, we present the design, synthesis, and biological evaluation of phenoxyacetamide-based inhibitors of the essential enzyme acetylcholinesterase 1 (AChE1). AChE1 is a validated insecticide target to control mosquito vectors of, e.g., malaria, dengue, and Zika virus infections. The inhibitors combine a mosquito versus human AChE selectivity with a high potency also for the resistance-conferring mutation G122S; two properties that have proven challenging to combine in a single compound. Structure activity relationship analyses and molecular dynamics simulations of inhibitor protein complexes have provided insights that elucidate the molecular basis for these properties. We also show that the inhibitors demonstrate in vivo insecticidal activity on disease-transmitting mosquitoes. Our findings support the concept of noncovalent, selective, and resistance-breaking inhibitors of AChE1 as a promising approach for future insecticide development.
6.	Lindgren, Anne-Li, 1965-, et al. (author) Childhood and the State - the State of Childhood 2004 In: Historisk Tidskrift. - 0345-469X .- 2002-4827. ; :1, s. 171-178 Journal article (other academic/artistic)
7.	Lindgren, Monica, 1958, et al. (author) Critical perspective in researching music education and equality – what, why and how? 2017 In: The 22nd Annual Conference of the Nordic Network for Research in Music Education, March 14-16. Conference paper (other academic/artistic)
8.	Taal, H. Rob, et al. (author) Common variants at 12q15 and 12q24 are associated with infant head circumference 2012 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:5, s. 532-538 Journal article (peer-reviewed)abstract To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.
9.	Willems, S. M., et al. (author) Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness 2017 In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8 Journal article (peer-reviewed)abstract Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P<5 × 10-8) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal muscle fibres (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic syndromes with involvement of psychomotor impairment (PEX14, LRPPRC and KANSL1). Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength on lower fracture risk. In conclusion, our findings provide new biological insight into the mechanistic underpinnings of grip strength and the causal role of muscular strength in age-related morbidities and mortality. © The Author(s) 2017.
10.	Agnér, Ulf, et al. (author) Bredäng : Miljonprogrammets föregångare 2018 Reports (other academic/artistic)abstract Denna publikation är ett resultat av läsåret 2017-2018 i kursen Restaureringskonst vid Kungl. Konsthögskolan, arkitekturavdelningen. Årets tema var bostadsarkitektur. Förvalta, förädla, förvanska? Under läsåret undersöktes bostadsarkitekturen som kulturarv, hur bostadshus och bostadsområden förvaltas, förädlas alternativt förvanskas genom restaureringsåtgärder, förtätningar och omvandlingar. II läsårets projektstudie ingick fem bostadsområden i södra Stockholm, utvalda för att representera varsin epok i 1900-talets bostadsutveckling. En projektgrupp för varje bostadsområde gjorde studier i olika skalor, från den utvalda lägenhetens detaljer, trapphuset och bostadshuset, gården och gatan till stadsdelsnivån.

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Type of publication: journal article (189); conference paper (17); book chapter (14); other publication (12); reports (8); doctoral thesis (7); show more...; book (3); editorial collection (2); review (1); show less...

Type of content: peer-reviewed (190); other academic/artistic (57); pop. science, debate, etc. (6)

Author/Editor: Lind, Lars (65); McCarthy, Mark I (59); Lindgren, Cecilia (55); Groop, Leif (54); Boehnke, Michael (49); Loos, Ruth J F (47); show more...; Mahajan, Anubha (46); Wareham, Nicholas J. (45); Laakso, Markku (45); Mohlke, Karen L (45); Ingelsson, Erik (44); Salomaa, Veikko (42); Stefansson, Kari (40); Langenberg, Claudia (38); Tuomilehto, Jaakko (38); van Duijn, Cornelia ... (37); Thorleifsson, Gudmar (37); Luan, Jian'an (37); Frayling, Timothy M (37); Kuusisto, Johanna (36); Deloukas, Panos (35); Uitterlinden, André ... (35); Jackson, Anne U. (35); Thorsteinsdottir, Un ... (34); Gieger, Christian (34); Grallert, Harald (34); Hansen, Torben (33); Hayward, Caroline (33); Prokopenko, Inga (33); Collins, Francis S. (33); Metspalu, Andres (32); Palmer, Colin N. A. (32); Hofman, Albert (32); Esko, Tõnu (32); Barroso, Ines (31); Perola, Markus (30); Hattersley, Andrew T (30); Harris, Tamara B (30); Rudan, Igor (29); Grarup, Niels (29); Pedersen, Oluf (29); Rotter, Jerome I. (29); Morris, Andrew D (29); Gudnason, Vilmundur (29); Boerwinkle, Eric (29); Tuomi, Tiinamaija (28); Hamsten, Anders (28); Gustafsson, Stefan (28); Zeggini, Eleftheria (28); Steinthorsdottir, Va ... (28); show less...

University: Uppsala University (101); Lund University (97); Karolinska Institutet (60); Linköping University (58); Umeå University (57); University of Gothenburg (38); show more...; Örebro University (16); Stockholm University (15); RISE (7); Högskolan Dalarna (7); Swedish University of Agricultural Sciences (6); Royal Institute of Technology (4); Luleå University of Technology (4); Mid Sweden University (4); Halmstad University (3); Linnaeus University (3); University of Gävle (2); Stockholm School of Economics (2); Södertörn University (2); Chalmers University of Technology (2); Karlstad University (2); The Royal Institute of Art (2); Kristianstad University College (1); Malmö University (1); Blekinge Institute of Technology (1); Marie Cederschiöld högskola (1); Sophiahemmet University College (1); Royal College of Music (1); show less...

Language: English (211); Swedish (42)

Research subject (UKÄ/SCB): Medical and Health Sciences (151); Social Sciences (45); Natural sciences (36); Agricultural Sciences (13); Humanities (12); Engineering and Technology (4)

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