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- Arndt, D. S., et al.
(författare)
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STATE OF THE CLIMATE IN 2017
- 2018
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Ingår i: Bulletin of The American Meteorological Society - (BAMS). - : American Meteorological Society. - 0003-0007 .- 1520-0477. ; 99:8, s. S1-S310
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Forskningsöversikt (refereegranskat)
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- Demichelis, F., et al.
(författare)
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TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort
- 2007
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Ingår i: Oncogene. - Basingstoke : Nature Publ. Group. - 0950-9232 .- 1476-5594. ; 26:31, s. 4596-4599
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Tidskriftsartikel (refereegranskat)abstract
- The identification of the TMPRSS2:ERG fusion in prostate cancer suggests that distinct molecular subtypes may define risk for disease progression. In surgical series, TMPRSS2:ERG fusion was identified in 50% of the tumors. Here, we report on a population-based cohort of men with localized prostate cancers followed by expectant (watchful waiting) therapy with 15% (17/111) TMPRSS2:ERG fusion. We identified a statistically significant association between TMPRSS2:ERG fusion and prostate cancer specific death (cumulative incidence ratio=2.7, P<0.01, 95% confidence interval=1.3–5.8). Quantitative reverse-transcription–polymerase chain reaction demonstrated high estrogen-regulated gene (ERG) expression to be associated with TMPRSS2:ERG fusion (P<0.005). These data suggest that TMPRSS2:ERG fusion prostate cancers may have a more aggressive phenotype, possibly mediated through increased ERG expression.
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- Adamo, Christin S., et al.
(författare)
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EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis
- 2022
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Ingår i: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297. ; 109:12, s. 2230-2252
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Tidskriftsartikel (refereegranskat)abstract
- EMILIN1 (elastin-microfibril-interface-located-protein-1) is a structural component of the elastic fiber network and localizes to the interface between the fibrillin microfibril scaffold and the elastin core. How EMILIN1 contributes to connective tissue integrity is not fully understood. Here, we report bi-allelic EMILIN1 loss-of-function variants causative for an entity combining cutis laxa, arterial tortuosity, aneurysm formation, and bone fragility, resembling autosomal-recessive cutis laxa type 1B, due to EFEMP2 (FBLN4) deficiency. In both humans and mice, absence of EMILIN1 impairs EFEMP2 extracellular matrix deposition and LOX activity resulting in impaired elastogenesis, reduced collagen crosslinking, and aberrant growth factor signaling. Collagen fiber ultrastructure and histopathology in EMILIN1- or EFEMP2-deficient skin and aorta corroborate these findings and murine Emilin1-/- femora show abnormal trabecular bone formation and strength. Altogether, EMILIN1 connects elastic fiber network with collagen fibril formation, relevant for both bone and vascular tissue homeostasis.
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- Bravo-Mosquera, P. D., et al.
(författare)
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Conceptual design and CFD analysis of a new prototype of agricultural aircraft
- 2018
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Ingår i: Aerospace Science and Technology. - : Elsevier. - 1270-9638 .- 1626-3219. ; 80, s. 156-176
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Tidskriftsartikel (refereegranskat)abstract
- In the agricultural aviation, there are several aerodynamic factors that must be optimized in order to contribute to the successful application of agricultural products, such as the high aerodynamic efficiency (L/D) required at the working phase and the influence of aircraft wingtip phenomena on the spray deposition and movement. For these reasons, in this research is presented the conceptual design of an advanced prototype of agricultural aircraft, whose main characteristic is an adaptive multi-winglet device installed on the wingtips, which optimized the main aerodynamic issues presented in its mission. Traditional aircraft design methods were used to develop and assess the suitability of the aircraft, focusing on its design requirements and tackling studies of weight sizing, pilot ergonomics, aerodynamics, stability, and performance. Subsequently, analytical and computational methods were used to design the adaptive multi-winglet device, which is composed by three winglets with its own geometry fitted on a tip-tank. Six configurations were created by modifying only the cant angle of each winglet in order to determine the arrangement that provides the best aerodynamic characteristics through a study of computational fluid dynamics (CFD), using the Reynolds–Averaged–Navier–Stokes (RANS) equations coupled with the Shear Stress Transport (SST) turbulence model. First, the flow around the wing and the multi-winglet section of the aircraft was investigated exclusively. Afterward, the airflow around the entire aircraft was studied at the product application condition, in order to compare the overall aerodynamic performance of the baseline concept along with the optimal multi-winglet configuration installed on the aircraft. Lift, drag and pitching moment coefficients were assessed, as well as the wingtip vortex structure of the most relevant configurations. Results of this study showed that adaptive multi-winglet devices are a promising alternative to improve the overall performance of an agricultural aircraft, because they provide control over the size and strength of the wake-spray interaction on the sprayed product, reduce the induced drag, reduce the bending moment and improve the aerodynamic efficiency of the aircraft.
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- De Rosa, G., et al.
(författare)
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Velocity-resolved Reverberation Mapping of Five Bright Seyfert 1 Galaxies
- 2018
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 866:2
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Tidskriftsartikel (refereegranskat)abstract
- We present the first results from a reverberation-mapping campaign undertaken during the first half of 2012, with additional data on one active galactic nucleus (AGN) (NGC 3227) from a 2014 campaign. Our main goals are (1) to determine the black hole masses from continuum-H beta reverberation signatures, and (2) to look for velocity-dependent time delays that might be indicators of the gross kinematics of the broad-line region. We successfully measure H beta time delays and black hole masses for five AGNs, four of which have previous reverberation mass measurements. The values measured here are in agreement with earlier estimates, though there is some intrinsic scatter beyond the formal measurement errors. We observe velocity-dependent H beta lags in each case, and find that the patterns have changed in the intervening five years for three AGNs that were also observed in 2007.
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