| 1. |
- Abdalla, H., et al.
(författare)
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Sensitivity of the Cherenkov Telescope Array for probing cosmology and fundamental physics with gamma-ray propagation
- 2021
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Ingår i: Journal of Cosmology and Astroparticle Physics. - : Institute of Physics Publishing (IOPP). - 1475-7516. ; :2
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Tidskriftsartikel (refereegranskat)abstract
- The Cherenkov Telescope Array (CTA), the new-generation ground-based observatory for gamma-ray astronomy, provides unique capabilities to address significant open questions in astrophysics, cosmology, and fundamental physics. We study some of the salient areas of gamma-ray cosmology that can be explored as part of the Key Science Projects of CTA, through simulated observations of active galactic nuclei (AGN) and of their relativistic jets. Observations of AGN with CTA will enable a measurement of gamma-ray absorption on the extragalactic background light with a statistical uncertainty below 15% up to a redshift z = 2 and to constrain or detect gamma-ray halos up to intergalactic-magnetic-field strengths of at least 0.3 pG. Extragalactic observations with CTA also show promising potential to probe physics beyond the Standard Model. The best limits on Lorentz invariance violation from gamma-ray astronomy will be improved by a factor of at least two to three. CTA will also probe the parameter space in which axion-like particles could constitute a significant fraction, if not all, of dark matter. We conclude on the synergies between CTA and other upcoming facilities that will foster the growth of gamma-ray cosmology.
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| 2. |
- Acero, F., et al.
(författare)
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Prospects for Cherenkov Telescope Array Observations of the Young Supernova Remnant RX J1713.7-3946
- 2017
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Ingår i: Astrophysical Journal. - : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 840:2
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Tidskriftsartikel (refereegranskat)abstract
- We perform simulations for future Cherenkov Telescope Array (CTA) observations of RX J1713.7-3946, a young supernova remnant (SNR) and one of the brightest sources ever discovered in very high energy (VHE) gamma rays. Special attention is paid to exploring possible spatial (anti) correlations of gamma rays with emission at other wavelengths, in particular X-rays and CO/H I emission. We present a series of simulated images of RX J1713.7-3946 for CTA based on a set of observationally motivated models for the gamma-ray emission. In these models, VHE gamma rays produced by high-energy electrons are assumed to trace the nonthermal X-ray emission observed by XMM-Newton, whereas those originating from relativistic protons delineate the local gas distributions. The local atomic and molecular gas distributions are deduced by the NANTEN team from CO and H I observations. Our primary goal is to show how one can distinguish the emission mechanism(s) of the gamma rays (i.e., hadronic versus leptonic, or a mixture of the two) through information provided by their spatial distribution, spectra, and time variation. This work is the first attempt to quantitatively evaluate the capabilities of CTA to achieve various proposed scientific goals by observing this important cosmic particle accelerator.
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| 3. |
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| 4. |
- Asp, Julia, 1973, et al.
(författare)
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Changes of the p16 gene but not the p53 gene in human chondrosarcoma tissues.
- 2000
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Ingår i: International journal of cancer. Journal international du cancer. - 0020-7136. ; 85:6, s. 782-6
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Tidskriftsartikel (refereegranskat)abstract
- The role of two important tumour suppressor genes, p16 and p53, was evaluated in cartilaginous tumour tissues. Genomic DNA from 22 chondrosarcomas, 5 benign chondroid tumours, 1 sample of reactive proliferative cartilage and 2 samples of normal cartilage were analysed using polymerase chain reaction, single strand conformational polymorphism, DNA sequencing and methylation-specific polymerase chain reaction. The p16 gene was found to be partly methylated in 5 high-grade chondrosarcomas and homozygously deleted in 1 chondrosarcoma. Moreover, a polymorphism was detected in 3 malignant tumours, but not in benign tumours or normal cartilage. Analysis of the p53 gene revealed an unchanged structure in all samples. These findings show a role for p16, but not p53, in chondrosarcoma.
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| 5. |
- Morozzi, P., et al.
(författare)
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Chemiluminescent fingerprints from airborne particulate matter: A luminol-based assay for the characterization of oxidative potential with kinetical implications
- 2021
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697. ; 789
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Tidskriftsartikel (refereegranskat)abstract
- In this study, a new chemiluminescent method based on the dependence of luminol light emission induced by free radicals in airborne particulate matter (PM) is proposed as a screening assay for the rapid characterization of samples from different sources based on their redox properties. This parameter is considered critical for assessing particulate matter toxicity and its impacts on human health. We propose a cell-free, luminescent assay to evaluate the redox potential of particulate matter directly on the filters employed to collect it. A joint chemometric approach based on Principal Component Analysis and Hotelling Analysis was applied to quickly sort out ambient particulate samples with a significantly different light emission profile caused by Luminol reaction. Based on Spearman correlation analysis, the association of the samples light emission intensity with their chemical composition and emission sources was attempted. The overall methodology was tested with certified reference materials and applied to two series of particulate matter samples previously subjected to thorough chemical speciation and subsequent source apportionment. The results show the effectiveness of the luminescent method, allowing the quick assessment of particulate matter oxidative potential, but providing further evidence on the complexity of the oxidative potential determination in this kind of samples. The chemometric processing of the whole dataset clearly highlights the distinct behavior among the two series of samples, the certificate standard reference materials, and the blank controls, supporting the suitability of the approach. (c) 2021 Published by Elsevier B.V.
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| 6. |
- Pansuriya, Twinkal C., et al.
(författare)
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Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome
- 2011
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:12, s. 1256-1261
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Tidskriftsartikel (refereegranskat)abstract
- Ollier disease and Maffucci syndrome are non-hereditary skeletal disorders characterized by multiple enchondromas (Ollier disease) combined with spindle cell hemangiomas (Maffucci syndrome). We report somatic heterozygous mutations in IDH1 (c.394C>T encoding an R132C substitution and c.395G>A encoding an R132H substitution) or IDH2 (c.516G>C encoding R172S) in 87% of enchondromas (benign cartilage tumors) and in 70% of spindle cell hemangiomas (benign vascular lesions). In total, 35 of 43 (81%) subjects with Ollier disease and 10 of 13 (77%) with Maffucci syndrome carried IDH1 (98%) or IDH2 (2%) mutations in their tumors. Fourteen of 16 subjects had identical mutations in separate lesions. Immunohistochemistry to detect mutant IDH1 R132H protein suggested intraneoplastic and somatic mosaicism. IDH1 mutations in cartilage tumors were associated with hypermethylation and downregulated expression of several genes. Mutations were also found in 40% of solitary central cartilaginous tumors and in four chondrosarcoma cell lines, which will enable functional studies to assess the role of IDH1 and IDH2 mutations in tumor formation.
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| 7. |
- Asp, Julia, 1973, et al.
(författare)
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Changes in p14(ARF) do not play a primary role in human chondrosarcoma tissues.
- 2001
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Ingår i: International journal of cancer. Journal international du cancer. - 0020-7136. ; 93:5, s. 703-5
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Tidskriftsartikel (refereegranskat)abstract
- The locus encoding the tumor suppressor p16 has been found to code for a second, different protein. This protein, p14(ARF), has been shown to protect p53 from degradation. Like p16, its gene is often altered in different cancers. In this study, the first unique exon, exon 1 beta, of p14(ARF), has been studied in 22 chondrosarcoma tissues using polymerase chain reaction, DNA sequencing and methylation-specific polymerase chain reaction. One chondrosarcoma was found to have exon 1 beta homozygously deleted, but neither mutations nor methylations were found in any of the chondrosarcomas. This indicates that genetic changes of p14(ARF) are a rare event in chondrosarcoma.
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| 8. |
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| 9. |
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| 10. |
- Fichot, F., et al.
(författare)
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Some considerations to improve the methodology to assess In-Vessel Retention strategy for high-power reactors
- 2018
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Ingår i: Annals of Nuclear Energy. - : Elsevier. - 0306-4549 .- 1873-2100. ; 119, s. 36-45
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Tidskriftsartikel (refereegranskat)abstract
- The In-Vessel Retention (IVR) strategy for Light Water Reactors (LWR) intends to stabilize and isolate corium and fission products in the reactor pressure vessel and in the primary circuit. This type of Severe Accident Management (SAM) strategy has already been incorporated in the SAM guidance (SAMG) of several operating small size LWR (reactor below 500 MWe (like VVER440)) and is part of the SAMG strategies for some Gen III + PWRs of higher power like the AP1000 or the APR1400. However, for high power reactors, estimations using current level of conservatism show that RPV failure caused by thermo-mechanical rupture takes place in some cases. A better estimation of the residual risk (probability of cases with vessel rupture) requires the use of models with a lower level of conservatism. In Europe, the IVMR project aims at providing new experimental data and a harmonized methodology for IVR. A synthesis of the methodology applied to demonstrate the efficiency of IVR strategy for VVER-440 in Europe (Finland, Slovakia, Hungary and Czech Republic) was made. It showed very consistent results, following quite comparable methodologies. The main weakness of the demonstration was identified in the evaluation of the heat flux that could be reached in transient situations, e.g. under the “3-layers” configuration, where the “focusing effect” may cause higher heat fluxes than in steady-state (due to transient “thin” metal layer on top). Analyses of various designs of reactors with a power between 900 and 1300 MWe were also made. Different models for the description of the molten pool were used: homogeneous, stratified with fixed configuration, stratified with evolving configuration. The last type of model provides the highest heat fluxes (above 3 MW/m2) whereas the first type provides the lowest heat fluxes (around 500 MW/m2) but is not realistic due to the non-miscibility of steel with UO2. Obviously, there is a need to reach a consensus about best estimate practices for IVR assessment to be used in the major codes for safety analysis, such as ASTEC, MELCOR, SOCRAT, MAAP, ATHLET-CD, SCDAP/RELAP, etc. Despite the model discrepancies, and leaving aside the unrealistic case of homogeneous pool, the average calculated heat fluxes in many cases are well above 1 MW/m2 which could reduce the residual thickness of the vessel considerably and threaten its integrity. Therefore, it is clear that the safety demonstration of IVR for high power reactors requires a more careful evaluation of the situations which can lead to formation of either a very thin top metal layer provoking focusing effect or significantly overheated metal, e.g. after oxide and metal layer inversion. It also requires an accurate mechanical analysis of the ablated vessel. The current approach followed by most experts for IVR is a compromise between a deterministic analysis using the significant knowledge gained during the last two decades and a probabilistic analysis to take into account large uncertainties due to the lack of data for some physical phenomena (such as transient effects) and due to excessive simplifications of models. A harmonization of the positions of safety authorities on the IVR strategy is necessary to allow decision making based on shared scientific knowledge. Currently, the acceptance criteria of a safety demonstration for IVR may be differently defined from one country to the other and the differences should be further discussed to reach harmonization on this important topic. This includes the accident scenarios to be considered in the demonstration and the modelling of the phenomena in the vessel. Such harmonization is one of the goals of IVMR project. A revised methodology is proposed, where the safety criterion is based not only on a comparison of the heat flux and the Critical Heat Flux (CHF) profiles as in current approaches but also on the minimum vessel thickness reached after ablation and the maximum integral loads that is applied to the vessel during the transient. The main advantage of this revised criterion is in consideration of both steady-state and transient loads on the RPV. Another advantage is that this criterion may be used in both probabilistic and deterministic approaches, whereas the current approaches are mostly deterministic (with deterministic calculations used only for estimates of uncertainty ranges of input parameters).
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