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1.	Golub, LM, et al. (author) Non-antibacterial tetracycline formulations: host-modulators in the treatment of periodontitis and relevant systemic diseases 2016 In: International dental journal. - : Elsevier BV. - 1875-595X .- 0020-6539. ; 66:3, s. 127-135 Journal article (peer-reviewed)
2.	Lechman, Eric R, et al. (author) miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells. 2016 In: Cancer Cell. - : Elsevier BV. - 1878-3686 .- 1535-6108. ; 29:2, s. 214-228 Journal article (peer-reviewed)abstract To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we generated a prognostic LSC-associated miRNA signature derived from functionally validated subpopulations of AML samples. For one signature miRNA, miR-126, high bioactivity aggregated all in vivo patient sample LSC activity into a single sorted population, tightly coupling miR-126 expression to LSC function. Through functional studies, miR-126 was found to restrain cell cycle progression, prevent differentiation, and increase self-renewal of primary LSC in vivo. Compared with prior results showing miR-126 regulation of normal hematopoietic stem cell (HSC) cycling, these functional stem effects are opposite between LSC and HSC. Combined transcriptome and proteome analysis demonstrates that miR-126 targets the PI3K/AKT/MTOR signaling pathway, preserving LSC quiescence and promoting chemotherapy resistance.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Lu, Jun (1); Ryan, M (1); Gu, Y. (1); Nilsson, Björn (1); Goldberg, M (1); Sorsa, T (1); show more...; Ebert, Benjamin L. (1); Golub, LM (1); Dick, John E. (1); Takayama, Naoya (1); Zandstra, Peter W (1); Wolff, M. (1); Naldini, Luigi (1); Walker, C. (1); Bader, Gary D. (1); Golub, Todd R. (1); Ciceri, Fabio (1); Elburki, MS (1); Tenenbaum, H (1); Hermans, Karin G (1); Minden, Mark (1); Lechman, Eric R (1); Gentner, Bernhard (1); Ng, Stanley W K (1); Schoof, Erwin M (1); van Galen, Peter (1); Kennedy, James A (1); Nucera, Silvia (1); Kaufmann, Kerstin B (1); Dobson, Stephanie M (1); Trotman-Grant, Aaron (1); Krivdova, Gabriela (1); Elzinga, Janneke (1); Mitchell, Amanda (1); Eppert, Kolja (1); Marke, Rene (1); Isserlin, Ruth (1); Voisin, Veronique (1); Wang, Jean C Y (1); show less...

University: Lund University (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2016 (2)

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