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  • Micci, Francesca, et al. (author)
  • t(3;21)(q22;q22) leading to truncation of the RYK gene in atypical chronic myeloid leukemia
  • 2009
  • In: Cancer Letters. - : Elsevier BV. - 1872-7980 .- 0304-3835. ; 277:2, s. 205-211
  • Journal article (peer-reviewed)abstract
    • The analysis of a small number of patients with atypical chronic myeloid leukemia showing balanced chromosomal translocations has revealed diverse tyrosine kinase fusion genes, most commonly involving FGFR1, PDGFRA, PDGFRB, JAK2, and ABL. We present a case of aCML with a 3q22;21q22-translocation that led to truncation of the receptor-like tyrosine kinase (RYK) gene and its juxtaposition with sequences from chromosome 21 including the ATP50 gene coding for a mitochondrial ATP synthase. The resulting fusion was not in frame, however, which is why we speculate that an abrogated RYK gene product rather than a chimeric protein might be the leukemogenic result. (c) 2009 Elsevier Ireland Ltd. All rights reserved.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Heim, Sverre (1)
Beiske, Klaus (1)
Panagopoulos, Ioanni ... (1)
Micci, Francesca (1)
Tjonnfjord, Geir E. (1)
Haugom, Lisbeth (1)
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University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2009 (1)

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