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PTPN22 is associate...
PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis : evidence for a further PsA-specific risk locus
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Bowes, John (author)
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Loehr, Sabine (author)
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Budu-Aggrey, Ashley (author)
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Uebe, Steffen (author)
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Bruce, Ian N. (author)
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Feletar, Marie (author)
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Marzo-Ortega, Helena (author)
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Helliwell, Philip (author)
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Ryan, Anthony W. (author)
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Kane, David (author)
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Korendowych, Eleanor (author)
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- Alenius, Gerd-Marie (author)
- Umeå universitet,Reumatologi
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Giardina, Emiliano (author)
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Packham, Jonathan (author)
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McManus, Ross (author)
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FitzGerald, Oliver (author)
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Brown, Matthew A. (author)
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Behrens, Frank (author)
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Burkhardt, Harald (author)
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McHugh, Neil (author)
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Huffmeier, Ulrike (author)
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Ho, Pauline (author)
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Reis, Andre (author)
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Barton, Anne (author)
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(creator_code:org_t)
- 2015-04-28
- 2015
- English.
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In: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 74:10, s. 1882-1885
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https://ard.bmj.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objectives Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis; it has a higher estimated genetic component than psoriasis alone, however most genetic susceptibility loci identified for PsA to date are also shared with psoriasis. Here we attempt to validate novel single nucleotide polymorphisms selected from our recent PsA Immunochip study and determine specificity to PsA. Methods A total of 15 single nucleotide polymorphisms were selected (P-Immunochip <1x10(-4)) for validation genotyping in 1177 cases and 2155 controls using TaqMan. Meta-analysis of Immunochip and validation data sets consisted of 3139 PsA cases and 11 078 controls. Novel PsA susceptibility loci were compared with data from two large psoriasis studies (WTCCC2 and Immunochip) to determine PsA specificity. Results We found genome-wide significant association to rs2476601, mapping to PTPN22 (p=1.49x10(-9), OR=1.32), but no evidence for association in the psoriasis cohort (p=0.34) and the effect estimates were significantly different between PsA and psoriasis (p=3.2x10(-4)). Additionally, we found genome-wide significant association to the previously reported psoriasis risk loci; NOS2 (rs4795067, p=5.27x10(-9)). Conclusions For the first time, we report genome-wide significant association of PTPN22 (rs2476601) to PsA susceptibility, but no evidence for association to psoriasis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Rheumatic Diseases
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bowes, John
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Loehr, Sabine
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Budu-Aggrey, Ash ...
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Uebe, Steffen
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Bruce, Ian N.
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Feletar, Marie
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show more...
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Marzo-Ortega, He ...
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Helliwell, Phili ...
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Ryan, Anthony W.
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Kane, David
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Korendowych, Ele ...
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Alenius, Gerd-Ma ...
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Giardina, Emilia ...
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Packham, Jonatha ...
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McManus, Ross
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FitzGerald, Oliv ...
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Brown, Matthew A ...
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Behrens, Frank
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Burkhardt, Haral ...
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McHugh, Neil
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Huffmeier, Ulrik ...
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Ho, Pauline
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Reis, Andre
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Barton, Anne
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Annals of the Rh ...
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Umeå University