Search: onr:"swepub:oai:DiVA.org:uu-336237" >
Height, selected ge...
Height, selected genetic markers and prostate cancer risk : results from the PRACTICAL consortium.
-
Lophatananon, Artitaya (author)
-
Stewart-Brown, Sarah (author)
-
Kote-Jarai, Zsofia (author)
-
show more...
-
Olama, Ali Amin Al (author)
-
Garcia, Sara Benlloch (author)
-
Neal, David E (author)
-
Hamdy, Freddie C (author)
-
Donovan, Jenny L (author)
-
Giles, Graham G (author)
-
Fitzgerald, Liesel M (author)
-
Southey, Melissa C (author)
-
Pharoah, Paul (author)
-
Pashayan, Nora (author)
-
- Gronberg, Henrik (author)
- Karolinska Institutet
-
- Wiklund, Fredrik (author)
- Karolinska Institutet
-
- Aly, Markus (author)
- Karolinska Institutet
-
Stanford, Janet L (author)
-
Brenner, Hermann (author)
-
Dieffenbach, Aida K (author)
-
Arndt, Volker (author)
-
Park, Jong Y (author)
-
Lin, Hui-Yi (author)
-
Sellers, Thomas (author)
-
Slavov, Chavdar (author)
-
Kaneva, Radka (author)
-
Mitev, Vanio (author)
-
Batra, Jyotsna (author)
-
Spurdle, Amanda (author)
-
Clements, Judith A (author)
-
Easton, Douglas (author)
-
Eeles, Rosalind A (author)
-
Muir, Kenneth (author)
-
show less...
-
(creator_code:org_t)
- 2017-08-01
- 2017
- English.
-
In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 117:5, s. 734-743
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer.METHODS: We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions.RESULTS: The results suggest that height is associated with high-grade prostate cancer risk. Men with height >180 cm are at a 22% increased risk as compared to men with height <173 cm (OR 1.22, 95% CI 1.01-1.48). Genetic variants in the growth pathway gene showed an association with prostate cancer risk. The aggregate scores of the selected variants identified a significantly increased risk of overall prostate cancer and high-grade prostate cancer by 13% and 15%, respectively, in the highest score group as compared to lowest score group.CONCLUSIONS: There was no evidence of gene-environment interaction between height and the selected candidate SNPs.Our findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Lophatananon, Ar ...
-
Stewart-Brown, S ...
-
Kote-Jarai, Zsof ...
-
Olama, Ali Amin ...
-
Garcia, Sara Ben ...
-
Neal, David E
-
show more...
-
Hamdy, Freddie C
-
Donovan, Jenny L
-
Giles, Graham G
-
Fitzgerald, Lies ...
-
Southey, Melissa ...
-
Pharoah, Paul
-
Pashayan, Nora
-
Gronberg, Henrik
-
Wiklund, Fredrik
-
Aly, Markus
-
Stanford, Janet ...
-
Brenner, Hermann
-
Dieffenbach, Aid ...
-
Arndt, Volker
-
Park, Jong Y
-
Lin, Hui-Yi
-
Sellers, Thomas
-
Slavov, Chavdar
-
Kaneva, Radka
-
Mitev, Vanio
-
Batra, Jyotsna
-
Spurdle, Amanda
-
Clements, Judith ...
-
Easton, Douglas
-
Eeles, Rosalind ...
-
Muir, Kenneth
-
show less...
- Articles in the publication
-
British Journal ...
- By the university
-
Uppsala University
-
Karolinska Institutet