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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007695naa a2200805 4500
001oai:DiVA.org:uu-387973
003SwePub
008190627s2019 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-158779
009oai:lup.lub.lu.se:cea12b58-f15a-4875-b7ae-ab84314a0082
009oai:prod.swepub.kib.ki.se:141034358
009oai:DiVA.org:liu-158578
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3879732 URI
0247 a https://doi.org/10.1002/cam4.21262 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1587792 URI
0247 a https://lup.lub.lu.se/record/cea12b58-f15a-4875-b7ae-ab84314a00822 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1410343582 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1585782 URI
040 a (SwePub)uud (SwePub)umud (SwePub)lud (SwePub)kid (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Häggström, Christelu Uppsala University,Umeå University,Umeå universitet,Uppsala universitet,Endokrinkirurgi,Umea Univ, Dept Biobank Res, Umea, Sweden,Enheten för biobanksforskning,Uppsala Univ, Sweden; Umea Univ, Sweden4 aut0 (Swepub:umu)chlham02
2451 0a Survival after radiotherapy versus radical cystectomy for primary muscle-invasive bladder cancer :b A Swedish nationwide population-based cohort study
264 c 2019-04
264 1b WILEY,c 2019
338 a electronic2 rdacarrier
500 a Funding Agencies|Swedish Cancer Society [CAN 2013/472]
520 a Background: Studies of survival comparing radical cystectomy (RC) and radiotherapy for muscle-invasive bladder cancer have provided inconsistent results and have methodological limitations. The aim of the study was to investigate risk of death after radiotherapy as compared to RC.Methods: We selected patients with muscle-invasive urothelial carcinoma without distant metastases, treated with radiotherapy or RC from 1997 to 2014 in the Bladder Cancer Data Base Sweden (BladderBaSe) and estimated absolute and relative risk of bladder cancer death and all-cause death. In a group of patients, theoretically eligible for a trial comparing radiotherapy and RC, we calculated risk difference in an instrumental variable analysis. We have not investigated chemoradiotherapy as this treatment was not used in the study time period.Results: The study included 3 309 patients, of those 17% were treated with radiotherapy and 83% with RC. Patients treated with radiotherapy were older, had more advanced comorbidity, and had a higher risk of death as compared to patients treated with RC (relative risks of 1.5-1.6). In the "trial population," all-cause death risk difference was 6 per 100 patients lower after radiotherapy at 5 years of follow-up, 95% confidence interval -41 to 29.Conclusion(s): Patient selection between the treatments make it difficult to evaluate results from conventionally adjusted and propensity-score matched survival analysis. When taking into account unmeasured confounding by instrumental variable analysis, no differences in survival was found between the treatments for a selected group of patients. Further clinical studies are needed to characterize this group of patients, which can serve as a basis for future comparison studies for treatment recommendations.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653 a bladder cancer
653 a muscle-invasive
653 a radical cystectomy
653 a radiotherapy
653 a urothelial carcinoma
653 a bladder cancer
653 a muscle-invasive
653 a radical cystectomy
653 a radiotherapy
653 a urothelial carcinoma
7001 a Garmo, Hansu Kings Coll London, Sch Canc & Pharmaceut Sci, TOUR, London, England;Reg Canc Ctr Uppsala Orebro, Uppsala, Sweden,King's College London4 aut
7001 a de Luna, Xavieru Umeå University,Umeå universitet,Statistik,Umea Univ, Dept Stat, USBE, Umea, Sweden4 aut0 (Swepub:umu)xade0001
7001 a Van Hemelrijck, Miekeu Karolinska Institute,King's College London,Kings Coll London, Sch Canc & Pharmaceut Sci, TOUR, London, England;Karolinska Inst, Inst Environm Med, Stockholm, Sweden4 aut
7001 a Söderkvist, Karinu Umeå University,Umeå universitet,Onkologi,Umea Univ, Dept Radiat Sci, Oncol, Umea, Sweden4 aut0 (Swepub:umu)kansom97
7001 a Aljabery, Firasu Linköpings universitet,Linköping University,Linkoping Univ, Div Urol, Dept Clin & Expt Med, Linkoping, Sweden,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)firab05
7001 a Ströck, Vivekau Sahlgrens Univ Hosp, Dept Urol, Gothenburg, Sweden,Sahlgrenska University Hospital4 aut
7001 a Hosseini, Abolfazlu Karolinska Univ Hosp, Dept Urol, Stockholm, Sweden,Karolinska University Hospital4 aut
7001 a Gårdmark, Trulsu Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Karolinska Inst, Stockholm, Sweden4 aut
7001 a Malmström, Per-Unou Uppsala University,Uppsala universitet,Urologkirurgi,Uppsala Univ, Sweden4 aut0 (Swepub:uu)perunoms
7001 a Jahnson, Staffanu Linköpings universitet,Linköping University,Linkoping Univ, Div Urol, Dept Clin & Expt Med, Linkoping, Sweden,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)staja74
7001 a Liedberg, Fredriku Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,Urology - urothelial cancer, Malmö,Lund University Research Groups,Skåne University Hospital,Skane Univ Hosp, Dept Urol, Malmo, Sweden;Lund Univ, Dept Translat Med, Malmo, Sweden4 aut0 (Swepub:lu)urok-fli
7001 a Holmberg, Larsu Uppsala University,Uppsala universitet,Endokrinkirurgi,Kings Coll London, Sch Canc & Pharmaceut Sci, TOUR, London, England,King's College London,Uppsala Univ, Sweden; Kings Coll London, England4 aut0 (Swepub:uu)larsholmb
7102 a Uppsala universitetb Endokrinkirurgi4 org
7730 t Cancer Medicined : WILEYg 8:5, s. 2196-2204q 8:5<2196-2204x 2045-7634
8564 u https://doi.org/10.1002/cam4.2126y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1331644/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.2126
8564 u https://umu.diva-portal.org/smash/get/diva2:1314312/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 u http://dx.doi.org/10.1002/cam4.2126x freey FULLTEXT
8564 u https://liu.diva-portal.org/smash/get/diva2:1334867/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-387973
8564 8u https://doi.org/10.1002/cam4.2126
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158779
8564 8u https://lup.lub.lu.se/record/cea12b58-f15a-4875-b7ae-ab84314a0082
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:141034358
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-158578

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