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Dairy products and ...
Dairy products and risk of hepatocellular carcinoma: The European Prospective Investigation into Cancer and Nutrition
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Duarte-Salles, T. (author)
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Fedirko, V. (author)
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Stepien, M. (author)
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Trichopoulou, A. (author)
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Bamia, C. (author)
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Lagiou, P. (author)
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- Lukanova, Annekatrin (author)
- Umeå universitet,Patologi
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Trepo, E. (author)
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Overvad, K. (author)
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Tjønneland, A. (author)
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Halkjær, J. (author)
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Boutron-Ruault, M. C. (author)
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Racine, A. (author)
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Cadeau, C. (author)
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Kühn, T. (author)
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Aleksandrova, K. (author)
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Trichopoulos, D. (author)
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Tsiotas, K. (author)
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Boffetta, P. (author)
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Palli, D. (author)
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Pala, V. (author)
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Tumino, R. (author)
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Sacerdote, C. (author)
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Panico, S. (author)
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Bueno-de-Mesquita, H. B. (author)
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Dik, V. K. (author)
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Peeters, P. H. (author)
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- Weiderpass, E. (author)
- Karolinska Institutet
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Torhild Gram, I. (author)
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Hjartåker, A. (author)
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Ramõn Quirõs, J. (author)
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Fonseca-Nunes, A. (author)
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Molina-Montes, E. (author)
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Dorronsoro, M. (author)
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Navarro Sanchez, C. (author)
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Barricarte, A. (author)
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- Lindkvist, Björn (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Sonestedt, Emily (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Johansson, Ingegerd (author)
- Umeå universitet,Institutionen för odontologi
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- Wennberg, Maria (author)
- Umeå universitet,Näringsforskning
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Khaw, K. T. (author)
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Wareham, N. (author)
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Travis, R. C. (author)
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Romieu, I. (author)
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Riboli, E. (author)
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Jenab, M. (author)
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(creator_code:org_t)
- 2014-03-07
- 2014
- English.
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In: International Journal of Cancer. - : Wiley-Liss Inc.. - 0020-7136 .- 1097-0215. ; 135:7, s. 1662-1672
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Abstract
Subject headings
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- Intake of dairy products has been associated with risk of some cancers, but findings are often inconsistent and information on hepatocellular carcinoma (HCC) risk is limited, particularly from prospective settings. The aim of our study was to investigate the association between consumption of total and specific dairy products (milk/cheese/yogurt) and their components (calcium/vitamin D/fats/protein), with first incident HCC (Ncases = 191) in the European Prospective Investigation into Cancer and Nutrition cohort, including a nested case-control subset (Ncases = 122) with the assessment of hepatitis B virus/hepatitis C virus infections status, liver damage and circulating insulin-like growth factor (IGF)-I levels. For cohort analyses, multivariable-adjusted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI). For nested case-control analyses, conditional logistic regression was used to calculate odds ratios and 95% CI. A total of 477,206 participants were followed-up for an average of 11 years (person-years follow-up = 5,415,385). In the cohort study, a significant positive HCC risk association was observed for total dairy products (highest vs. lowest tertile, HR = 1.66, 95% CI: 1.13-2.43; ptrend = 0.012), milk (HR = 1.51, 95% CI: 1.02-2.24; ptrend = 0.049), and cheese (HR = 1.56, 95% CI: 1.02-2.38; ptrend = 0.101), but not yogurt (HR = 0.94, 95% CI: 0.65-1.35). Dietary calcium, vitamin D, fat and protein from dairy sources were associated with increased HCC risk, whereas the same nutrients from nondairy sources showed inverse or null associations. In the nested case-control study, similar results were observed among hepatitis-free individuals. Results from this large prospective cohort study suggest that higher consumption of dairy products, particularly milk and cheese, may be associated with increased HCC risk. Validation of these findings in other populations is necessary. Potential biologic mechanisms require further exploration. What's New? Currently, the role of dairy product intake in the development of hepatocellular carcinoma (HCC) is unclear. Using detailed data from a large multi-centric prospective cohort, this study investigated the association between consumption of total and specific dairy products with first incident HCC. The study found that higher dairy product consumption, particularly milk and cheese, was associated with increased HCC risk. Dietary calcium, vitamin D, fat and protein did not explain the observed associations. However, higher circulating IGF-I levels may play a role. © 2014 UICC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- calcium
- dairy products
- hepatocellular carcinoma
- prospective cohort
- fat
- protein
- somatomedin C
- vitamin D
- adult
- aged
- article
- calcium intake
- cancer risk
- case control study
- cheese
- cohort analysis
- controlled study
- dairy product
- dietary intake
- disease association
- Europe
- fat content
- fat intake
- female
- follow up
- food composition
- hepatitis B
- hepatitis C
- human
- liver cell carcinoma
- liver injury
- major clinical study
- male
- medical society
- milk
- nutritional assessment
- priority journal
- prospective study
- protein content
- protein intake
- risk factor
- very elderly
- vitamin intake
- Aged
- 80 and over
- Carcinoma
- Hepatocellular
- Case-Control Studies
- Follow-Up Studies
- Humans
- Liver Neoplasms
- Middle Aged
- Nutritional Status
- Prognosis
- Prospective Studies
- Risk Factors
- Young Adult
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Duarte-Salles, T ...
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Fedirko, V.
-
Stepien, M.
-
Trichopoulou, A.
-
Bamia, C.
-
Lagiou, P.
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show more...
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Lukanova, Anneka ...
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Trepo, E.
-
Overvad, K.
-
Tjønneland, A.
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Halkjær, J.
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Boutron-Ruault, ...
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Racine, A.
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Cadeau, C.
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Kühn, T.
-
Aleksandrova, K.
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Trichopoulos, D.
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Tsiotas, K.
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Boffetta, P.
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Palli, D.
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Pala, V.
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Tumino, R.
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Sacerdote, C.
-
Panico, S.
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Bueno-de-Mesquit ...
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Dik, V. K.
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Peeters, P. H.
-
Weiderpass, E.
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Torhild Gram, I.
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Hjartåker, A.
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Ramõn Quirõs, J.
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Fonseca-Nunes, A ...
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Molina-Montes, E ...
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Dorronsoro, M.
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Navarro Sanchez, ...
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Barricarte, A.
-
Lindkvist, Björn
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Sonestedt, Emily
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Johansson, Ingeg ...
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Wennberg, Maria
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Khaw, K. T.
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Wareham, N.
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Travis, R. C.
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Romieu, I.
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Riboli, E.
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Jenab, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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University of Gothenburg
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Lund University
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Umeå University
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Karolinska Institutet