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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05879naa a2200817 4500 | |
| 001 | oai:lup.lub.lu.se:986d3a14-9167-453b-babe-482de481c9ce | |
| 003 | SwePub | |
| 008 | 160401s2007 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/1651722 URI |
| 024 | 7 | a https://doi.org/10.1007/s00234-006-0165-12 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Nilsson, Christeru Skåne University Hospital4 aut0 (Swepub:lu)neur-cni |
| 245 | 1 0 | a Tracking the neurodegeneration of parkinsonian disorders - A pilot study |
| 264 | c 2007-01-03 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2007 |
| 300 | a 9 s. | |
| 520 | a The purpose of the study was to explore the possibilities of using diffusion tensor imaging (DTI) and tractography (DTT) for the differential diagnosis and monitoring of disease progression in idiopathic Parkinson's disease (IPD), compared with the atypical parkinsonian disorders multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). A 3.0-T MR scanner was used. DTI was acquired using a single-shot EPI sequence with diffusion encoding in 32 directions and a voxel size of 2×2×2 mm3. DTI data were analysed and DTT was performed using the PRIDE fibre tracking tool supplied by the manufacturer. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) within each tract were determined. DTI and DTT images in patients with moderate to advanced MSA demonstrated degeneration of the middle cerebellar peduncles and pontine crossing tracts, with decreased FA and increased ADC. This accounted for most of the pontine and cerebellar atrophy characteristic of this disease. In contrast, patients with PSP showed a selective degeneration of the superior cerebellar peduncle. Three-dimensional images of whole-brain white matter tracts demonstrated a reduction of cortical projection fibres in all patients with PSP. Visualization of the selective degeneration of individual fibre tracts, using DTI and DTT, adds qualitative data facilitating the differential diagnosis of parkinsonian disorders. Repeated measurements of FA and ADC values in a whole fibre tract might be used for monitoring disease progression and studying the effect of treatment in neuroprotective trials. The results are preliminary considering the small number of subjects in the study. © Springer-Verlag 2007. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a Diffusion | |
| 653 | a Magnetic resonance imaging | |
| 653 | a Multiple system atrophy | |
| 653 | a Parkinson's disease | |
| 653 | a Progressive supranuclear palsy | |
| 653 | a adult | |
| 653 | a aged | |
| 653 | a anisotropy | |
| 653 | a article | |
| 653 | a cerebellum atrophy | |
| 653 | a clinical article | |
| 653 | a controlled study | |
| 653 | a diagnostic value | |
| 653 | a differential diagnosis | |
| 653 | a diffusion coefficient | |
| 653 | a diffusion tensor imaging | |
| 653 | a disease course | |
| 653 | a female | |
| 653 | a human | |
| 653 | a male | |
| 653 | a nerve degeneration | |
| 653 | a nerve projection | |
| 653 | a Parkinson disease | |
| 653 | a parkinsonism | |
| 653 | a pilot study | |
| 653 | a priority journal | |
| 653 | a progressive supranuclear palsy | |
| 653 | a qualitative analysis | |
| 653 | a Shy Drager syndrome | |
| 653 | a three dimensional imaging | |
| 653 | a white matter | |
| 700 | 1 | a Markenroth Bloch, Karinu Philips Medical Systems4 aut0 (Swepub:lu)klin-km0 |
| 700 | 1 | a Brockstedt, Sarau Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)rafy-sbr |
| 700 | 1 | a Lätt, J.u Skåne University Hospital4 aut0 (Swepub:lu)radf-jla |
| 700 | 1 | a Widner, Håkanu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)mphy-hwi |
| 700 | 1 | a Larsson, Elna-Marieu Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)drad-eml |
| 710 | 2 | a Skåne University Hospitalb Philips Medical Systems4 org |
| 773 | 0 | t Neuroradiologyd : Springer Science and Business Media LLCg 49:2, s. 111-119q 49:2<111-119x 1432-1920x 0028-3940 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17200869&dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1007/s00234-006-0165-1y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/165172 |
| 856 | 4 8 | u https://doi.org/10.1007/s00234-006-0165-1 |
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