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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005879naa a2200817 4500
001oai:lup.lub.lu.se:986d3a14-9167-453b-babe-482de481c9ce
003SwePub
008160401s2007 | |||||||||||000 ||eng|
024a https://lup.lub.lu.se/record/1651722 URI
024a https://doi.org/10.1007/s00234-006-0165-12 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
100a Nilsson, Christeru Skåne University Hospital4 aut0 (Swepub:lu)neur-cni
2451 0a Tracking the neurodegeneration of parkinsonian disorders - A pilot study
264 c 2007-01-03
264 1b Springer Science and Business Media LLC,c 2007
300 a 9 s.
520 a The purpose of the study was to explore the possibilities of using diffusion tensor imaging (DTI) and tractography (DTT) for the differential diagnosis and monitoring of disease progression in idiopathic Parkinson's disease (IPD), compared with the atypical parkinsonian disorders multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). A 3.0-T MR scanner was used. DTI was acquired using a single-shot EPI sequence with diffusion encoding in 32 directions and a voxel size of 2×2×2 mm3. DTI data were analysed and DTT was performed using the PRIDE fibre tracking tool supplied by the manufacturer. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) within each tract were determined. DTI and DTT images in patients with moderate to advanced MSA demonstrated degeneration of the middle cerebellar peduncles and pontine crossing tracts, with decreased FA and increased ADC. This accounted for most of the pontine and cerebellar atrophy characteristic of this disease. In contrast, patients with PSP showed a selective degeneration of the superior cerebellar peduncle. Three-dimensional images of whole-brain white matter tracts demonstrated a reduction of cortical projection fibres in all patients with PSP. Visualization of the selective degeneration of individual fibre tracts, using DTI and DTT, adds qualitative data facilitating the differential diagnosis of parkinsonian disorders. Repeated measurements of FA and ADC values in a whole fibre tract might be used for monitoring disease progression and studying the effect of treatment in neuroprotective trials. The results are preliminary considering the small number of subjects in the study. © Springer-Verlag 2007.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a Diffusion
653 a Magnetic resonance imaging
653 a Multiple system atrophy
653 a Parkinson's disease
653 a Progressive supranuclear palsy
653 a adult
653 a aged
653 a anisotropy
653 a article
653 a cerebellum atrophy
653 a clinical article
653 a controlled study
653 a diagnostic value
653 a differential diagnosis
653 a diffusion coefficient
653 a diffusion tensor imaging
653 a disease course
653 a female
653 a human
653 a male
653 a nerve degeneration
653 a nerve projection
653 a Parkinson disease
653 a parkinsonism
653 a pilot study
653 a priority journal
653 a progressive supranuclear palsy
653 a qualitative analysis
653 a Shy Drager syndrome
653 a three dimensional imaging
653 a white matter
700a Markenroth Bloch, Karinu Philips Medical Systems4 aut0 (Swepub:lu)klin-km0
700a Brockstedt, Sarau Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)rafy-sbr
700a Lätt, J.u Skåne University Hospital4 aut0 (Swepub:lu)radf-jla
700a Widner, Håkanu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)mphy-hwi
700a Larsson, Elna-Marieu Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)drad-eml
710a Skåne University Hospitalb Philips Medical Systems4 org
773t Neuroradiologyd : Springer Science and Business Media LLCg 49:2, s. 111-119q 49:2<111-119x 1432-1920x 0028-3940
856u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17200869&dopt=Abstracty FULLTEXT
856u http://dx.doi.org/10.1007/s00234-006-0165-1y FULLTEXT
8564 8u https://lup.lub.lu.se/record/165172
8564 8u https://doi.org/10.1007/s00234-006-0165-1

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