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  • Pye, Stephen R. (author)

Influence of Insulin-Like Growth Factor Binding Protein (IGFBP)-1 and IGFBP-3 on Bone Health: Results from the European Male Ageing Study

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-04-19
  • Springer Science and Business Media LLC,2011

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:a6c5d63a-7239-4168-9dbd-586fd7f4773d
  • https://lup.lub.lu.se/record/1986997URI
  • https://doi.org/10.1007/s00223-011-9484-2DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • The aim of this study was to determine the influence of insulin-like growth factor binding protein (IGFBP)-1, IGFBP-3, and IGF-I on calcaneal ultrasound parameters in middle-aged and elderly European men. Men aged 40-79 years were recruited from population registers for participation in the European Male Ageing Study (EMAS). Subjects were invited by letter to complete a postal questionnaire and to attend for an interviewer-assisted questionnaire, quantitative ultrasound (QUS) of the calcaneus, and a fasting blood sample from which serum levels of IGFBP-1, IGFBP-3, IGF-I, estradiol (E-2), and SHBG were assayed. The questionnaires included the Physical Activity Scale for the Elderly (PASE) and questions about smoking and alcohol consumption. Estimated bone mineral density (eBMD) was derived as a function of the QUS parameters speed of sound and broadband ultrasound attenuation. Height and weight were measured in all subjects. 3057 men, mean age 59.7 years (standard deviation 11.0) were included in the analysis. After adjusting for age, center, and BMI, higher levels of IGFBP-1 were associated with lower eBMD. Higher levels of both IGFBP-3 and IGF-I were associated with higher eBMD. After further adjustment for PASE score, current smoking, alcohol consumption, free E-2, and SHBG, IGFBP-3 and IGF-I, though not IGFBP-1, remained significantly associated with eBMD. IGFBP-1 was associated with bone health, though the effect could be explained by other factors. IGFBP-3 and IGF-I were independent determinants of bone health in middle-aged and elderly European men.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Almusalam, Bader (author)
  • Boonen, Steven (author)
  • Vanderschueren, Dirk (author)
  • Borghs, Herman (author)
  • Gielen, Evelien (author)
  • Adams, Judith E. (author)
  • Ward, Kate A. (author)
  • Bartfai, Gyorgy (author)
  • Casanueva, Felipe F. (author)
  • Finn, Joseph D. (author)
  • Forti, Gianni (author)
  • Giwercman, AleksanderLund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups(Swepub:lu)kir-agi (author)
  • Han, Thang S. (author)
  • Huhtaniemi, Ilpo T. (author)
  • Kula, Krzysztof (author)
  • Labrie, Fernand (author)
  • Lean, Michael E. J. (author)
  • Pendleton, Neil (author)
  • Punab, Margus (author)
  • Silman, Alan J. (author)
  • Wu, Frederick C. W. (author)
  • O'Neill, Terence W. (author)
  • Reproduktionsmedicin, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Calcified Tissue International: Springer Science and Business Media LLC88:6, s. 503-5101432-08270171-967X

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