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Genome-wide meta-an...
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-04-25
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Springer Science and Business Media LLC,2010
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LIBRIS-ID:oai:lup.lub.lu.se:e24186cf-b864-4612-9009-34dafc946a18
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https://lup.lub.lu.se/record/1619189URI
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https://doi.org/10.1038/ng.571DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Consistent but indirect evidence has implicated genetic factors in smoking behavior1,2. We report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium (n = 74,053). We also partnered with the European Network of Genetic and Genomic Epidemiology (ENGAGE) and Oxford-GlaxoSmithKline (Ox-GSK) consortia to follow up the 15 most significant regions (n > 140,000). We identified three loci associated with number of cigarettes smoked per day. The strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3 (rs1051730[A], b = 1.03, standard error (s.e.) = 0.053, beta = 2.8 x 10(-73)). Two 10q25 SNPs (rs1329650[G], b = 0.367, s. e. = 0.059, beta = 5.7 x 10(-10); and rs1028936[A], b = 0.446, s. e. = 0.074, beta = 1.3 x 10(-9)) and one 9q13 SNP in EGLN2 (rs3733829[G], b = 0.333, s. e. = 0.058, P = 1.0 x 10(-8)) also exceeded genome-wide significance for cigarettes per day. For smoking initiation, eight SNPs exceeded genome-wide significance, with the strongest association at a nonsynonymous SNP in BDNF on chromosome 11 (rs6265[C], odds ratio (OR) = 1.06, 95% confidence interval (Cl) 1.04-1.08, P = 1.8 x 10(-8)). One SNP located near DBH on chromosome 9 (rs3025343[G], OR = 1.12, 95% Cl 1.08-1.18, P = 3.6 x 10(-8)) was significantly associated with smoking cessation.
Subject headings and genre
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Kim, YunJung
(author)
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Dackor, Jennifer
(author)
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Boerwinkle, Eric
(author)
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Franceschini, Nora
(author)
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Ardissino, Diego
(author)
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Bernardinelli, Luisa
(author)
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Mannucci, Pier M.
(author)
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Mauri, Francesco
(author)
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Merlini, Piera A.
(author)
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Absher, Devin
(author)
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Assimes, Themistocles L.
(author)
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Fortmann, Stephen P.
(author)
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Iribarren, Carlos
(author)
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Knowles, Joshua W.
(author)
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Quertermous, Thomas
(author)
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Ferrucci, Luigi
(author)
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Tanaka, Toshiko
(author)
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Bis, Joshua C.
(author)
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Furberg, Curt D.
(author)
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Haritunians, Talin
(author)
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McKnight, Barbara
(author)
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Psaty, Bruce M.
(author)
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Taylor, Kent D.
(author)
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Thacker, Evan L.
(author)
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Almgren, PeterLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-pal
(author)
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
(author)
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Ladenvall, ClaesLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)med-cll
(author)
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Boehnke, Michael
(author)
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Jackson, Anne U.
(author)
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Mohlke, Karen L.
(author)
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Stringham, Heather M.
(author)
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Tuomilehto, Jaakko
(author)
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Benjamin, Emelia J.
(author)
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Hwang, Shih-Jen
(author)
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Levy, Daniel
(author)
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Preis, Sarah Rosner
(author)
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Vasan, Ramachandran S.
(author)
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Duan, Jubao
(author)
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Gejman, Pablo V.
(author)
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Levinson, Douglas F.
(author)
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Sanders, Alan R.
(author)
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Shi, Jianxin
(author)
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Lips, Esther H.
(author)
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Mckay, James D.
(author)
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Agudo, Antonio
(author)
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Barzan, Luigi
(author)
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Bencko, Vladimir
(author)
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Benhamou, Simone
(author)
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Castellsague, Xavier
(author)
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Canova, Cristina
(author)
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Conway, David I.
(author)
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Fabianova, Eleonora
(author)
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Foretova, Lenka
(author)
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Janout, Vladimir
(author)
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Healy, Claire M.
(author)
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Holcatova, Ivana
(author)
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Kjaerheim, Kristina
(author)
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Lagiou, Pagona
(author)
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Lissowska, Jolanta
(author)
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Lowry, Ray
(author)
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Macfarlane, Tatiana V.
(author)
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Mates, Dana
(author)
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Richiardi, Lorenzo
(author)
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Rudnai, Peter
(author)
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Szeszenia-Dabrowska, Neonilia
(author)
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Zaridze, David
(author)
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Znaor, Ariana
(author)
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Lathrop, Mark
(author)
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Brennan, Paul
(author)
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Bandinelli, Stefania
(author)
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Frayling, Timothy M.
(author)
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Guralnik, Jack M.
(author)
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Milaneschi, Yuri
(author)
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Perry, John R. B.
(author)
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Altshuler, David
(author)
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Elosua, Roberto
(author)
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Kathiresan, Sek
(author)
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Lucas, Gavin
(author)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(author)
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O'Donnell, Christopher J.
(author)
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Salomaa, Veikko
(author)
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Schwartz, Stephen M.
(author)
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Voight, Benjamin F.
(author)
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Penninx, Brenda W.
(author)
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Smit, Johannes H.
(author)
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Vogelzangs, Nicole
(author)
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Boomsma, Dorret I.
(author)
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de Geus, Eco J. C.
(author)
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Vink, Jacqueline M.
(author)
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Willemsen, Gonneke
(author)
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Chanock, Stephen J.
(author)
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Gu, Fangyi
(author)
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Hankinson, Susan E.
(author)
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Hunter, David J.
(author)
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Hofman, Albert
(author)
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Tiemeier, Henning
(author)
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Uitterlinden, Andre G.
(author)
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van Duijn, Cornelia M.
(author)
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Walter, Stefan
(author)
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Chasman, Daniel I.
(author)
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Everett, Brendan M.
(author)
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Pare, Guillaume
(author)
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Ridker, Paul M.
(author)
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Li, Ming D.
(author)
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Maes, Hermine H.
(author)
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Audrain-McGovern, Janet
(author)
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Posthuma, Danielle
(author)
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Thornton, Laura M.
(author)
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Lerman, Caryn
(author)
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Kaprio, Jaakko
(author)
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Rose, Jed E.
(author)
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Ioannidis, John P. A.
(author)
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Kraft, Peter
(author)
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Lin, Dan-Yu
(author)
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Sullivan, Patrick F.
(author)
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Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC42:5, s. 134-4411546-17181061-4036
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