Handbook of Pharmacogenomics and Stratified Medicine / Edited by Sandosh Padmanabhan.

• Part 1: Introduction -- Ch. 1 Pharmacogenomics and Stratified Medicine -- Part 2: Basic Genetics -- Ch. 2 Basic Genetics: The Cell, Mitosis and Meiosis, and Mendelian Laws / Guan Wang -- Ch. 3 The Human Genome, Gene Regulation, and Genomic Variation / Kathleen M. Murphy, Aislinn Cooper, Edward S. Tobias -- Ch. 4 Epigenetics / Tony McBryan, Peter D. Adams -- Part 3: Experimental and Discovery Platforms -- Ch. 5 Animal Models in Pharmacogenomics / Erin Olson, Delyth Graham -- Ch. 6 Human Lymphoblastoid Cell Lines in Pharmacogenomics / Jae-Pil Jeon -- Ch. 7 Liver Expression Quantitative Trait Loci (eQTL) and Related Approaches in Pharmacogenomic Studies / Dylan M. Glubb, Amy S. Etheridge, Eric Seiser, Federico Innocenti -- Ch. 8 Next-Generation Sequencing / Pawel Herzyk -- Ch. 9 Proteomics / Holger Husi, Amaya Albalat -- Ch. 10 Metabolomics / Karl Burgess, Naomi Rankin, Stefan Weidt -- Ch. 11 Stem Cells / Komal Loya -- Part 4: Statistics, Bioinformatics and Databases -- Ch. 12 Fundamentals of Complex Trait Genetics and Association Studies / Jahad Alghamdi, Sandosh Padmanabhan -- Ch. 13 Bioinformatics: Concepts, Methods, and Data / Scott W. Robinson, Avid M. Afzal, David P. Leader -- Ch. 14 PharmGKB: The Pharmacogenomics Knowledgebase / Julia M. Barbarino, Michelle Whirl-Carrillo, Teri E. Klein, Russ B. Altman -- Part 5: Clinical Trials -- Ch. 15 Clinical Trials in Pharmacogenomics and Stratified Medicine -- Part 6: Fundamental Pharmacogenomics -- Ch. 16 CYP450 and Ethnicity / Joseph McGraw -- Ch. 17 Pharmacokinetic Pharmacogenomics / Safaa Mohammed M. Alsanosi, Craig Skiffington, Sandosh Padmanabhan -- Ch. 18 Pharmacodynamic Pharmacogenomics / Linsay McCallum, Stefanie Lip, Sandosh Padmanabhan -- Ch. 19 MicroRNA: Regulation of P450 and Pharmacogenetics / Miki Nakajima, Tsuyoshi Yokoi. 
• Part 7: Application in Therapeutics -- Ch. 20 Adverse Drug Reactions / Lauren Walker, Vincent Yip, Munir Pirmohamed -- Ch. 21 HLA and the Pharmacogenomics of Drug Hypersensitivity / Katie D. White, Silvana Gaudieri, Elizabeth J. Phillips -- Ch. 22 Drug-Induced Liver Injury / Thomas J. Urban, Hans Tillmann -- Ch. 23 Hemostasis and Anticoagulants / Matthew R. Wilson, R. Campbell Tait -- Ch. 24 Pharmacogenomics of Warfarin / Ann K. Daly -- Ch. 25 Pharmacogenomics of Clopidogrel / Betti Giusti, Claudia Saracini, Silvia Galora, Rossella Marcucci -- Ch. 26 Pharmacogenetics of Antidepressant Drugs / Chiara Fabbri, Alessandro Minarini, Yoshihiko Matsumoto, Alessandro Serretti -- Ch. 27 Personalized Medicine of Alzheimer's Disease / Ramón Cacabelos, Pablo Cacabelos, Clara Torrellas -- Ch. 28 Asthma / Dominick Shaw, Michael Portelli, Ian Sayers -- Ch. 29 Rheumatoid Arthritis / Jisna R Paul, Deepali Sen, Prabha Ranganathan -- Ch. 30 Pharmacogenomics of Oral Antidiabetic Drugs / Vangelis G. Manolopoulos, Georgia Ragia -- Ch. 31 Genomics and Pharmacogenomics of Lipid-Lowering Therapies / Kieran F. Docherty, Sandosh Padmanabhan -- Ch. 32 Hypertension Pharmacogenomics / Yan Gong, Caitrin W. McDonough, Sandosh Padmanabhan, Julie A Johnson -- Ch. 33 QTc and Sudden Cardiac Death / Catriona Brown, Sandosh Padmanabhan -- Ch. 34 Stratified Medicine for Pancreatic Cancer / David K. Chang, Nigel B. Jamieson, Sean M. Grimmond, Andrew V. Biankin, for the Australian Pancreatic Cancer Genome Initiative -- Ch. 35 Pharmacogenomics in Anesthesia / Shiv Kumar Singh, Tushar Dixit -- Ch. 36 Tuberculosis / Geetha Ramachandran, Soumya Swaminathan -- Ch. 37 Hepatitis C Virus / A.J. Thompson, P. Clark, A. Aghemo -- Ch. 38 Pharmacogenomics of Antifungal Agents / H.R. Ashbee, M.H. Gilleece -- Ch. 39 Advances in Understanding and Treatment of Human African Trypanosomiasis: Divergent Diseases Caused by Distinct Parasites / Federica Giordani, Roy Mwenechanya, Michael P. Barrett. 
• Part 8: Implementation and Regulatory -- Ch. 40 Implementing Clinical Pharmacogenetics: Point-of-Care and Pre-Emptive Testing / Stuart A. Scott -- Ch. 41 Ethical Considerations in Pharmacogenomic Testing and Research in Pediatrics / Chi Dang Hornik, Cait O'Donnell, Raymond Barfield -- Ch. 42 PGx/Biomarker Utilization for Regulatory Decision Making / Yu Sakamoto, Yasuto Otsubo, Akihiro Ishiguro, Yoshiaki Uyama -- Part 9: Global Perspective -- Ch. 43 Population Diversity and Pharmacogenomics in Africa / Collen Masimirembwa, Collet Dandara, Julia Hasler -- Ch. 44 Pharmacogenomics in China / Wei Zhang, Hong-Hao Zhou, Zhao-Qian Liu, Xiao-Ping Chen, Yi-Jing He -- Ch. 45 Pharmacogenomics in Brazil / Guilherme Suarez-Kurtz, Mara Helena Hutz -- Ch. 46 Pharmacogenomics in India / Umamaheswaran Gurusamy, Deepak Gopal Shewade. 

• Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development.

Ämnesord

Pharmacogenetics.  (LCSH)

Individualized Medicine.  (MeSH)

Publikations- och innehållstyp

615.7 (DDC)

Vde (kssb/8 (machine generated))