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Divergent synthesis...
Divergent synthesis of D-erythro-sphingosine, L-threo-sphingosine, and their regioisomers
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- Olofsson, Berit (author)
- Royal Institute of Technology, Sweden
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- Somfai, Peter (author)
- KTH,Kemi,Royal Institute of Technology, Sweden
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(creator_code:org_t)
- 2003-02-15
- 2003
- English.
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In: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 68:6, s. 2514-2517
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Starting from a vinyl epoxide, a divergent synthesis of four sphingosine isomers is described. The remaining four isomers can easily be synthesized using the same methodology. Although numerous syntheses of sphingosine have been published, this is the first general route leading to all eight isomers in this important compound class. The synthetic strategy relies on regioselective opening of a vinyl epoxide and a vinylaziridine in the allylic position.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Keyword
- beta-amino alcohols
- stereoselective synthesis
- enantioselective synthesis
- l-serine
- route
- regiodivergent
- derivatives
- products
- organisk kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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