SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:liu-97672"
 

Search: onr:"swepub:oai:DiVA.org:liu-97672" > Tumour PDGF-BB expr...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Hosaka, KayokoKarolinska Institutet (author)

Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-07-08
  • Nature Publishing Group: Nature Communications,2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-97672
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-97672URI
  • https://doi.org/10.1038/ncomms3129DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:127291200URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Research Council||Swedish Cancer Foundation||Karolinska Institute Foundation||Karolinska Institute||Tianjin Natural Science Foundation (CMM-Tianjin)|09ZCZDSF04400|Torsten Soderbergs foundation||European Union Integrated Project of Metoxia|222741|European Research Council (ERC)|250021|
  • Anti-platelet-derived growth factor (PDGF) drugs are routinely used in front-line therapy for the treatment of various cancers, but the molecular mechanism underlying their dose-dependent impact on vascular remodelling remains poorly understood. Here we show that anti-PDGF drugs significantly inhibit tumour growth and metastasis in high PDGF-BB-producing tumours by preventing pericyte loss and vascular permeability, whereas they promote tumour cell dissemination and metastasis in PDGF-BB-low-producing or PDGF-BB-negative tumours by ablating pericytes from tumour vessels. We show that this opposing effect is due to PDGF-beta signalling in pericytes. Persistent exposure of pericytes to PDGF-BB markedly downregulates PDGF-beta and inactivation of the PDGF-beta signalling decreases integrin alpha 1 beta 1 levels, which impairs pericyte adhesion to extracellular matrix components in blood vessels. Our data suggest that tumour PDGF-BB levels may serve as a biomarker for selection of tumour-bearing hosts for anti-PDGF therapy and unsupervised use of anti-PDGF drugs could potentially promote tumour invasion and metastasis.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Yang, YunlongKarolinska Institutet (author)
  • Seki, TakahiroKarolinska Institutet (author)
  • Nakamura, MasakiKarolinska Institutet (author)
  • Andersson, PatrikKarolinska Institutet (author)
  • Rouhi, PegahKarolinska Institute, Sweden (author)
  • Yang, XiaojuanKarolinska Institute, Sweden (author)
  • Jensen, LasseKarolinska Institutet,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Karolinska Institute, Sweden(Swepub:liu)larje86 (author)
  • Lim, SharonKarolinska Institutet (author)
  • Feng, NinghanKarolinska Institute, Sweden (author)
  • Xue, YuanKarolinska Institute, Sweden (author)
  • Li, XuriSun Yat Sen University, Peoples R China (author)
  • Larsson, OlaKarolinska Institutet (author)
  • Ohhashi, ToshioShinshu University, Japan (author)
  • Cao, YihaiLinköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Karolinska Institute, Sweden(Swepub:liu)yihca64 (author)
  • Karolinska InstitutetKarolinska Institute, Sweden (creator_code:org_t)

Related titles

  • In:Nature Communications: Nature Publishing Group: Nature Communications4:21292041-1723

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view