Search: onr:"swepub:oai:DiVA.org:oru-41456" > Prospective study o...
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000 | 05941naa a2200481 4500 | |
001 | oai:DiVA.org:oru-41456 | |
003 | SwePub | |
008 | 150114s2009 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:119525741 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-414562 URI |
024 | 7 | a https://doi.org/10.1093/jnci/djp3062 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1195257412 URI |
040 | a (SwePub)orud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Stark, Jennifer R.u Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USA4 aut |
245 | 1 0 | a Prospective study of Trichomonas vaginalis infection and prostate cancer incidence and mortality :b Physicians' Health Study |
264 | c 2009-09-09 | |
264 | 1 | a Cary, USA :b Oxford University Press,c 2009 |
338 | a print2 rdacarrier | |
520 | a Background: A recent nested case-control study found that the presence of antibodies against Trichomonas vaginalis, a common nonviral sexually transmitted infection, was positively associated with subsequent incidence of prostate cancer. We confirmed these findings in an independent population and related serostatus for antibodies against T vaginalis to prostate cancer incidence and mortality.Methods: We conducted a case-control study nested within the Physicians' Health Study that included 673 case subjects with prostate cancer and 673 individually matched control subjects who had available plasma samples. Plasma from blood samples collected at baseline was assayed for antibodies against T vaginalis with an enzyme-linked immunosorbent assay. We used conditional logistic regression to estimate the odds ratios (ORs) of incident prostate cancer, extraprostatic prostate cancer, and cancer that would ultimately progress to bony metastases or prostate cancer-specific death.Results: Although not statistically significant, the magnitude of the association between T vaginalis-seropositive status and overall prostate cancer risk (OR = 1.23, 95% confidence interval [CI] = 0.94 to 1.61) was similar to that reported previously. Furthermore, a seropositive status was associated with statistically significantly increased risks of extraprostatic prostate cancer (OR = 2.17, 95% CI = 1.08 to 4.37) and of cancer that would ultimately progress to bony metastases or prostate cancer-specific death (OR = 2.69, 95% CI = 1.37 to 5.28).Conclusions: This large prospective case-control study obtained further support for an association between a seropositive status for antibodies against T vaginalis and the risk of prostate cancer, with statistically significant associations identified for the risk of extraprostatic prostate cancer and for clinically relevant, potentially lethal prostate cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Judson, Gregoryu Department of Epidemiology, Harvard School of Public Health, Boston, USA4 aut |
700 | 1 | a Alderete, John F.u School of Molecular Biosciences, Washington State University, Pullman, USA4 aut |
700 | 1 | a Mundodi, Vasanthakrishnau Molecular Biosciences, Washington State University, Pullman, USA4 aut |
700 | 1 | a Kucknoor, Ashwini S.u Molecular Biosciences, Washington State University, Pullman, USA4 aut |
700 | 1 | a Giovannucci, Edward L.u Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Nutrition, School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USA4 aut |
700 | 1 | a Platz, Elizabeth A.u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA4 aut |
700 | 1 | a Sutcliffe, Siobhanu Alvin J. Siteman Cancer Center and Department of Surgery, Washington University School of Medicine, St. Louis, USA4 aut |
700 | 1 | a Fall, Katja,d 1971-u Karolinska Institutet4 aut0 (Swepub:oru)kafl |
700 | 1 | a Kurth, Tobiasu Department of Epidemiology, Harvard School of Public Health, Boston, USA; Division of Preventive Medicine, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston; Institut National de la Santé et de la Recherche Médicale, Unit 708 Neuroepidemiology and Pierre et Marie Curie University, Paris, France4 aut |
700 | 1 | a Ma, Jingu Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USA4 aut |
700 | 1 | a Stampfer, Meir J.u Department of Nutrition, School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USA4 aut |
700 | 1 | a Mucci, Lorelei A.u Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USA4 aut |
710 | 2 | a Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women´s Hospital and Harvard Medical School, Boston, USAb Department of Epidemiology, Harvard School of Public Health, Boston, USA4 org |
773 | 0 | t Journal of the National Cancer Instituted Cary, USA : Oxford University Pressg 101:20, s. 1406-11q 101:20<1406-11x 0027-8874x 1460-2105 |
856 | 4 | u https://academic.oup.com/jnci/article-pdf/101/20/1406/18084834/djp306.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-41456 |
856 | 4 8 | u https://doi.org/10.1093/jnci/djp306 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:119525741 |
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