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- Hemminki, K.Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden (author)
Molecular epidemiology of VHL gene mutations in renal cell carcinoma patients : relation to dietary and other factors
- Article/chapterEnglish2002
Publisher, publication year, extent ...
- Oxford, United Kingdom :Oxford University Press,2002
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- LIBRIS-ID:oai:DiVA.org:oru-48982
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-48982URI
- https://doi.org/10.1093/carcin/23.5.809DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1955048URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Carcinogenic chemicals act through DNA damage and mitogenic effects. No established mechanism explains the cancer preventive effects, if any, of food items, such as vegetables and fruit. If such data were available, preferably on tumor-initiating genes, the evidence for the protective effects would become stronger. The von Hipple-Lindau (VHL) gene is the tumor suppressor gene predisposing to both sporadic renal cell carcinoma (RCC) and von Hippel-Lindau disease. We have earlier analyzed VHL mutations in RCCs from 102 Swedish patients identified in a case-control study and here examine associations between patient characteristics, including dietary habits and mutations, considering the type of mutation. The results are given as odds ratios (OR), separately for smokers and all patients. In univariate analysis, consumption of vegetables and citrus fruit decreased the frequency of VHL mutations among smokers and citrus fruit among all patients. In multivariate analysis of smokers' characteristics, welding fumes showed a risk of 5.63 for multiple VHL mutations. In smokers, citrus fruit decreased the OR of GC to AT mutations to 0.13 and that of multiple mutations to 0.17; vegetables decreased the OR for single mutations to 0.22. Among all subjects, welding fumes were a risk factor and citrus fruit a protective factor. Additionally, an intake of selenium protected against multiple mutations. The present results provide evidence that the intake of vegetables, selenium and particularly of citrus fruit protects the renal VHL gene from mutational insults that may be endogenous or common in a population. Even though most of the associations are biologically plausible, and vegetables and fruit were an a priori hypothesis, fortuitous results cannot be ruled out in this relatively small study.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Adult
- Aged
- Carcinoma
- Renal Cell/epidemiology/*genetics
- Humans
- Kidney Neoplasms/epidemiology/*genetics
- Ligases/*genetics
- Male
- Middle Aged
- *Molecular Epidemiology
- *Mutation
- *Tumor Suppressor Proteins
- *Ubiquitin-Protein Ligases
- Von Hippel-Lindau Tumor Suppressor Protein
- von Hippel-Lindau Disease/*genetics
Added entries (persons, corporate bodies, meetings, titles ...)
- Jiang, Y.Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden (author)
- Ma, X.Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden (author)
- Yang, K.Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden (author)
- Egevad, L.Karolinska Institutet (author)
- Lindblad, Per,1953-Department of Urology, Sundsvall Hospital, Sundsvall, Sweden(Swepub:oru)pld (author)
- Karolinska InstitutetDepartment of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden (creator_code:org_t)
Related titles
- In:CarcinogenesisOxford, United Kingdom : Oxford University Press23:5, s. 809-8150143-33341460-2180
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