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International renal...
International renal-cell cancer study. VIII. Role of diuretics, other anti-hypertensive medications and hypertension
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- McLaughlin, J. K. (author)
- National Cancer Institute, Bethesda, Maryland, United States; International Epidemiology Institute, Rockville, Maryland, United States
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- Chow, W. H. (author)
- National Cancer Institute, Bethesda, Maryland, United States
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- Mandel, J. S. (author)
- Division of Environmental Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States
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- Mellemgaard, A. (author)
- Danish Cancer Society, Copenhagen, Denmark
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- McCredie, M. (author)
- Cancer Epidemiology Research Unit, New South Wales Cancer Council, Kings Cross, Australia
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- Lindblad, Per, 1953- (author)
- Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden
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- Schlehofer, B. (author)
- Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
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- Pommer, W. (author)
- Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
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- Niwa, S. (author)
- Westat Inc., Rockville, Maryland, United States
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- Adami, H. O. (author)
- Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
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(creator_code:org_t)
- New York, USA : John Wiley & Sons, 1995
- 1995
- English.
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In: International Journal of Cancer. - New York, USA : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 63:2, s. 216-221
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Risk of renal-cell cancer in relation to use of diuretics, other anti-hypertensive medications and hypertension was assessed in a multi-center, population-based, case-control study conducted in Australia, Denmark, Germany, Sweden and the United States, using a shared protocol and questionnaire. A total of 1,732 histologically confirmed cases and 2,309 controls, frequency-matched to cases by age and sex, were interviewed. The association between renal-cell cancer and the drugs was estimated by relative risks (RRs) and 95% confidence intervals (CIs). Risks were increased among users of diuretics and other anti-hypertensive medications. After adjustment for hypertension, risk for diuretics was reduced to unity, except among long-term (15+ years) users. Risk for use of non-diuretic anti-hypertensive drugs remained significantly elevated and increased further with duration of use. Overall risk was not enhanced when both classes of medications were used. Excess risk was not restricted to any specific type of diuretic or anti-hypertensive drug and no trend was observed with estimated lifetime consumption of any particular type of product. The RR for hypertension after adjustment for diuretics and other anti-hypertensive medications was 1.4 (95% CI = 1.2-1.7), although among non-users of any anti-hypertensive medications, there was little excess risk associated with a history of hypertension. Exclusion of drug use that first occurred within 5 years of cancer diagnosis or interview did not alter the associations. Our findings suggest small effects on renal-cell cancer risk associated with hypertension and use of diuretics and other anti-hypertensive medications. However, because of potential misclassifications of these highly correlated variables, it is difficult to distinguish the effect of treatment from its indication, hypertension.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Antihypertensive Agents/*adverse effects
- Carcinoma
- Renal Cell/*etiology
- Case-Control Studies
- Diuretics/*adverse effects/classification
- Humans
- Hypertension/*complications
- Kidney Neoplasms/*etiology
- Odds Ratio
- Risk
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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McLaughlin, J. K ...
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Chow, W. H.
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Mandel, J. S.
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Mellemgaard, A.
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McCredie, M.
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Lindblad, Per, 1 ...
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show more...
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Schlehofer, B.
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Pommer, W.
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Niwa, S.
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Adami, H. O.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Örebro University