Obsessive-compulsive disorder, serotonin and oxytocin: treatment response and side effects

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Fältnamn	Indikatorer	Metadata
000		04530nam a2200541 4500
001		oai:DiVA.org:oru-51438
003		SwePub
008		160725s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
020		a 9789175291536q print
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-514382 URI
040		a (SwePub)oru
041		a engb eng
042		9 SwePub
072	7	a vet2 swepub-contenttype
072	7	a dok2 swepub-publicationtype
100	1	a Humble, Mats B.,d 1952-u Örebro universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:oru)mhe
245	1 0	a Obsessive-compulsive disorder, serotonin and oxytocin :b treatment response and side effects
264	1	a Örebro :b Örebro university,c 2016
300		a 133 s.
338		a electronic2 rdacarrier
490	0	a Örebro Studies in Medicine,x 1652-4063 ;v 148
520		a Obsessive-compulsive disorder (OCD), with a prevalence of 1-2 %, frequently leads a chronic course. Persons with OCD are often reluctant to seek help and, if they do, their OCD is often missed. This is unfortunate, since active treatment may substantially improve social function and quality of life. Serotonin reuptake inhibitors (SRIs) have welldocumented efficacy in OCD, but delayed response may be problematic. Methods to predict response have been lacking. Because SRIs are effective, pathophysiological research on OCD has focussed on serotonin. However, no clear aberrations of serotonin have been found, thus other mechanisms ought to be involved.Our aims were to facilitate clinical detection and assessment of OCD, to search for biochemical correlates of response and side-effects in SRI treatment of OCD and to identify any possible involvement of oxytocin in the pathophysiology of OCD.In study I, we tested in 402 psychiatric out-patients the psychometric properties of a concise rating scale, “Brief Obsessive Compulsive Scale” (BOCS). BOCS was shown to be easy to use and have excellent discriminant validity in relation to other common psychiatric diagnoses.Studies II-V were based on 36 OCD patients from a randomised controlled trial of paroxetine, clomipramine or placebo. In study II, contrary to expectation, we found that the change (decrease) of serotonin in whole blood was most pronounced in non-responders to SRI. This is likely to reflect inflammatory influence on platelet turnover rather than serotonergic processes within the central nervous system.In studies IV-V, we found relations between changes of oxytocin in plasma and the anti-obsessive response, and between oxytocin and the SRI related delay of orgasm, respectively. In both cases, the relation to central oxytocinergic mechanisms is unclear. In males, delayed orgasm predicted anti-obsessive response.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Allmänmedicin0 (SwePub)302242 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex General Practice0 (SwePub)302242 hsv//eng
653		a Adverse effects
653		a Obsessive-compulsive disorder
653		a Orgasm
653		a Oxytocin
653		a Randomised controlled trial
653		a Rating scale
653		a Response prediction
653		a Serotonin
653		a Serotonin uptake inhibitors
653		a Sexual function
653		a Psychiatry
653		a Psykiatri
700	1	a Engström, Ingemar,c Adjungerad professoru Örebro universitet,Institutionen för medicinska vetenskaper4 ths0 (Swepub:oru)iem
700	1	a von Knorring, Lars,c Professoru Uppsala universitet4 ths
700	1	a Kjellin, Lars,c Docentu Örebro universitet,Institutionen för hälsovetenskaper4 ths0 (Swepub:oru)lkn
700	1	a Träskman-Bendz, Lil,c Professoru Institutionen för kliniska vetenskaper, Lunds universitet4 opn
710	2	a Örebro universitetb Institutionen för medicinska vetenskaper4 org
856	4	u https://oru.diva-portal.org/smash/get/diva2:949869/PREVIEW01.pngx Previewy preview image
856	4	u https://oru.diva-portal.org/smash/get/diva2:949869/COVER01.pdfy cover
856	4	u https://oru.diva-portal.org/smash/get/diva2:949869/FULLTEXT01.pdfx primaryx Raw objecty fulltext
856	4	u https://oru.diva-portal.org/smash/get/diva2:949869/SPIKBLAD01.pdfy spikblad
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-51438

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