A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort

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A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood : Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort

Stamate, Daniel (författare): Division of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester, UK; Data Science & Soft Computing Lab, London, UK; Computing Department, Goldsmiths College, University of London, London, UK

Kim, Min (författare): Steno Diabetes Center Copenhagen, Gentofte, Denmark

Proitsi, Petroula (författare): Karolinska Institutet

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Weestwood, Sarah (författare): Department of Psychiatry, University of Oxford, Oxford, UK

Baird, Alison (författare): Department of Psychiatry, University of Oxford, Oxford, UK

Nevado-Holgado, Alejo (författare): Department of Psychiatry, University of Oxford, Oxford, UK

Hye, Abdul (författare): Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK

Bos, Isabelle (författare): Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands

Vos, Stephanie J.B. (författare): Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands

Vandenberghe, Rik (författare): Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands

Teunissen, Charlotte E. (författare): Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands

Kate, Mara Ten (författare): Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands

Scheltens, Philip (författare): Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands

Gabel, Silvy (författare): Department of Clinical Chemistry, Neurochemistry Laboratory, Amsterdam Neuroscience, Amsterdam University Medical Centers, Vrije Universiteit, the Netherlands; University Hospital Leuven, Leuven, Belgium; Department of Neurosciences, Laboratory for Cognitive Neurology, KU, Leuven, Belgium

Meersmans, Karen (författare): University Hospital Leuven, Leuven, Belgium; Department of Neurosciences, Laboratory for Cognitive Neurology, KU, Leuven, Belgium

Blin, Olivier (författare): AIX Marseille University, INS, Ap‐hm, Marseille, France

Richardson, Jill (författare): Neurosciences Therapeutic Area GlaxoSmithKline R&D, Stevenage, UK

De Roeck, Ellen (författare): Faculty of Psychology & Educational Sciences Vrije, Universiteit Brussel (VUB), Brussels, Belgium; Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium; Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium

Engelborghs, Sebastiaan (författare): Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium; Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium; Department of Neurology, UZ Brussel and Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium

Sleegers, Kristel (författare): Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Belgium

Bordet, Régis (författare): University of Lille, Inserm, CHU Lille, Lille, France

Ramit, Lorena (författare): Alzheimer's Disease & Other Cognitive Disorders Unit, Hospital Clínic‐IDIBAPS, Barcelona, Spain

Kettunen, Petronella (författare): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology

Tsolaki, Magda (författare): 1st Department of Neurology, AHEPA University Hospital, Makedonia, Thessaloniki, Greece

Verhey, Frans (författare): Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands

Alcolea, Daniel (författare): Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

Lléo, Alberto (författare): Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

Peyratout, Gwemdoline (författare): University Hospital of Lausanne, Lausanne, Switzerland

Tainta, Mikael (författare): Center for Research and Advanced Therapies, Fundacion CITA‐alzheimer Fundazioa, Donostia/San Sebastian, Spain

Johannsen, Peter (författare): Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Freund-Levi, Yvonne, 1956- (författare): Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK; Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institute, Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden

Frölich, Lutz (författare): Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany

Dobricic, Valerija (författare): Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany

Frisoni, Giovanni B. (författare): University of Geneva, Geneva, Switzerland; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy

Molinuevo, José L. (författare): University of Lille, Inserm, CHU Lille, Lille, France; Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain

Wallin, Anders, 1950 (författare): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology

Popp, Julius (författare): University Hospital of Lausanne, Lausanne, Switzerland; Department of Mental Health and Psychiatry, Geriatric Psychiatry, Geneva University Hospitals, Geneva, Switzerland

Martinez-Lage, Pablo (författare): Center for Research and Advanced Therapies, Fundacion CITA‐alzheimer Fundazioa, Donostia/San Sebastian, Spain

Bertram, Lars (författare): Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany; Department of Psychology, University of Oslo, Oslo, Norway

Blennow, Kaj, 1958 (författare): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Zetterberg, Henrik, 1973 (författare): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Streffer, Johannes (författare): Reference Center for Biological Markers of Dementia (BIODEM), Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium

Visser, Pieter J. (författare): Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands

Lovestone, Simon (författare): Department of Psychiatry, University of Oxford, Oxford, UK; Janssen‐Cilag UK Ltd, Oxford, UK

Legido-Quigley, Christina (författare): Steno Diabetes Center Copenhagen, Gentofte, Denmark; Institute of Pharmaceutical Science, King's College London, London, UK

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(creator_code:org_t)

2019-01
2019
Engelska.
Ingår i: Alzheimer’s & Dementia. - : John Wiley & Sons. - 2352-8737. ; 5:C, s. 933-938

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://doi.org/10.1...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; https://gup.ub.gu.se...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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IntroductionMachine learning (ML) may harbor the potential to capture the metabolic complexity in Alzheimer Disease (AD). Here we set out to test the performance of metabolites in blood to categorize AD when compared to CSF biomarkers.MethodsThis study analyzed samples from 242 cognitively normal (CN) people and 115 with AD‐type dementia utilizing plasma metabolites (n = 883). Deep Learning (DL), Extreme Gradient Boosting (XGBoost) and Random Forest (RF) were used to differentiate AD from CN. These models were internally validated using Nested Cross Validation (NCV).ResultsOn the test data, DL produced the AUC of 0.85 (0.80–0.89), XGBoost produced 0.88 (0.86–0.89) and RF produced 0.85 (0.83–0.87). By comparison, CSF measures of amyloid, p‐tau and t‐tau (together with age and gender) produced with XGBoost the AUC values of 0.78, 0.83 and 0.87, respectively.DiscussionThis study showed that plasma metabolites have the potential to match the AUC of well‐established AD CSF biomarkers in a relatively small cohort. Further studies in independent cohorts are needed to validate whether this specific panel of blood metabolites can separate AD from controls, and how specific it is for AD as compared with other neurodegenerative disorders.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)

Nyckelord

EMIF‐AD
Alzheimer's disease
Metabolomics
Biomarkers
Machine‐Learning

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Av författaren/redakt...: Stamate, Daniel; Kim, Min; Proitsi, Petroul ...; Weestwood, Sarah; Baird, Alison; Nevado-Holgado, ...; visa fler...; Hye, Abdul; Bos, Isabelle; Vos, Stephanie J ...; Vandenberghe, Ri ...; Teunissen, Charl ...; Kate, Mara Ten; Scheltens, Phili ...; Gabel, Silvy; Meersmans, Karen; Blin, Olivier; Richardson, Jill; De Roeck, Ellen; Engelborghs, Seb ...; Sleegers, Kriste ...; Bordet, Régis; Ramit, Lorena; Kettunen, Petron ...; Tsolaki, Magda; Verhey, Frans; Alcolea, Daniel; Lléo, Alberto; Peyratout, Gwemd ...; Tainta, Mikael; Johannsen, Peter; Freund-Levi, Yvo ...; Frölich, Lutz; Dobricic, Valeri ...; Frisoni, Giovann ...; Molinuevo, José ...; Wallin, Anders, ...; Popp, Julius; Martinez-Lage, P ...; Bertram, Lars; Blennow, Kaj, 19 ...; Zetterberg, Henr ...; Streffer, Johann ...; Visser, Pieter J ...; Lovestone, Simon; Legido-Quigley, ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Geriatrik

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin

Artiklar i publikationen: Alzheimer’s & De ...

Av lärosätet: Örebro universitet; Karolinska Institutet; Göteborgs universitet

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