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RENEB intercomparis...
RENEB intercomparison exercises analyzing micronuclei (Cytokinesis-block Micronucleus Assay)
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Depuydt, Julie (author)
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Baeyens, Ans (author)
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Barnard, Stephen (author)
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Beinke, Christina (author)
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Benedek, Anett (author)
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Beukes, Philip (author)
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Buraczewska, Iwona (author)
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Darroudi, Firouz (author)
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De Sanctis, Stefania (author)
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Domingue, Inmaculada (author)
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Gil, Octavia Monteiro (author)
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Hadjidekova, Valeria (author)
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Kis, Eniko (author)
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Kulka, Ulrike (author)
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Lista, Florigio (author)
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Lumniczky, Katalin (author)
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M'kacher, Radhia (author)
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Moquet, Jayne (author)
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Obreja, Doina (author)
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Oestreicher, Ursula (author)
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Pajic, Jelena (author)
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Pastor, Nuria (author)
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Popova, Ljubomira (author)
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Regalbuto, Elisa (author)
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Ricoul, Michelle (author)
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Sabatier, Laure (author)
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Slabbert, Jacobus (author)
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Sommer, Sylwester (author)
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Testa, Antonella (author)
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Thierens, Hubert (author)
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- Wojcik, Andrzej (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Vral, Anne (author)
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(creator_code:org_t)
- 2016-08-15
- 2017
- English.
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In: International Journal of Radiation Biology. - : Informa UK Limited. - 0955-3002 .- 1362-3095. ; 93:1, s. 36-47
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https://www.tandfonl...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Purpose: In the framework of the 'Realizing the European Network of Biodosimetry' (RENEB) project, two intercomparison exercises were conducted to assess the suitability of an optimized version of the cytokinesis-block micronucleus assay, and to evaluate the capacity of a large laboratory network performing biodosimetry for radiation emergency triages. Twelve European institutions participated in the first exercise, and four non-RENEB labs were added in the second one. Materials and methods: Irradiated blood samples were shipped to participating labs, whose task was to culture these samples and provide a blind dose estimate. Micronucleus analysis was performed by automated, semi-automated and manual procedures. Results: The dose estimates provided by network laboratories were in good agreement with true administered doses. The most accurate estimates were reported for low dose points (<= 0.94 Gy). For higher dose points (>= 2.7 Gy) a larger variation in estimates was observed, though in the second exercise the number of acceptable estimates increased satisfactorily. Higher accuracy was achieved with the semi-automated method. Conclusion: The results of the two exercises performed by our network demonstrate that the micronucleus assay is a useful tool for large-scale radiation emergencies, and can be successfully implemented within a large network of laboratories.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Biodosimetry
- micronucleus assay
- triage
- radiation accident
- RENEB
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Depuydt, Julie
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Baeyens, Ans
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Barnard, Stephen
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Beinke, Christin ...
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Benedek, Anett
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Beukes, Philip
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show more...
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Buraczewska, Iwo ...
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Darroudi, Firouz
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De Sanctis, Stef ...
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Domingue, Inmacu ...
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Gil, Octavia Mon ...
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Hadjidekova, Val ...
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Kis, Eniko
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Kulka, Ulrike
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Lista, Florigio
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Lumniczky, Katal ...
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M'kacher, Radhia
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Moquet, Jayne
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Obreja, Doina
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Oestreicher, Urs ...
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Pajic, Jelena
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Pastor, Nuria
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Popova, Ljubomir ...
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Regalbuto, Elisa
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Ricoul, Michelle
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Sabatier, Laure
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Slabbert, Jacobu ...
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Sommer, Sylweste ...
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Testa, Antonella
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Thierens, Hubert
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Wojcik, Andrzej
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Vral, Anne
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Mechanical Engin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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Stockholm University